DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Epm2a and CG10089

DIOPT Version :9

Sequence 1:	NP_034276.2	Gene:	Epm2a / 13853	MGIID:	1341085	Length:	330	Species:	Mus musculus
Sequence 2:	NP_001261803.1	Gene:	CG10089 / 39517	FlyBaseID:	FBgn0036369	Length:	447	Species:	Drosophila melanogaster

Alignment Length:	172	Identity:	39/172 - (22%)
Similarity:	66/172 - (38%)	Gaps:	43/172 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse   155 HYSRILPNIWLGSCPRQLEHVTI---KLKHELGVTAVMNFQTEWDIIQNSSGCNRYPEPMTPDTM 216
            |..::||.:::|:.....:|..:   |:.|.:.:                   :..|..:.||
  Fly     4 HMGKVLPGLYVGNYRDSKDHAQLERFKISHIIAI-------------------HDSPRRLLPD-- 47

Mouse   217 MKLYKEEGLSYIWMPTPDMSTEGRVQMLPQ--AVC--LLHALLENGHTVYVHCNAGVGRSTAAVC 277
             |.|    |..:...|||       |.|.|  :||  .:||.......|.:||.||:.||.....
  Fly    48 -KHY----LCVMASDTPD-------QNLSQYFSVCNDFIHAARLREGNVLIHCLAGMSRSVTVAV 100

Mouse   278 GWLHYVIGWNLRKVQYFIMAKRPAVYIDEDALAQAQ-QDFSQ 318
            .::......|.::....:.|.|...  :.:|..|:| |:|.|
  Fly   101 AYIMTATHLNWKEALKVVRAGRAVA--NPNAGFQSQLQEFEQ 140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epm2a	NP_034276.2	CBM20_laforin	1..128	CDD:99881
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95278	102..106
		PTPc	157..303	CDD:304379	32/152 (21%)
		Glucan phosphatase signature motif CXAGXGR. /evidence=ECO:0000250\|UniProtKB:O95278	265..271		3/5 (60%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95278	266..271		2/4 (50%)
CG10089	NP_001261803.1	DSPc	4..139	CDD:238073	37/169 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1716
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900