Protein Alignment CREB1 and CrebB

DIOPT Version :9

• Sequence 1: NP_001358355.1
• Gene: CREB1 / 1385
• HGNCID: 2345
• Length: 341
• Species: Homo sapiens
• Sequence 2: NP_001334685.1
• Gene: CrebB / 32817
• FlyBaseID: FBgn0265784
• Length: 331
• Species: Drosophila melanogaster
• Alignment Length: 370
• Identity: 114/370 - (30%)
• Similarity: 144/370 - (38%)
• Gaps: 135/370 - (36%)

Human     5 SGAENQQSG---DAAVTEAEN----------------QQMTVQAQPQ--IATLA-----QVSMPA 43
            :||.|...|   .:.:|...|                .|..:||.|.  |.|.|     |.::.|
  Fly    64 TGATNNAQGGGVSSVLTTTANCNIQYPIQTLAQHGLQVQSVIQANPSGVIQTAAGTQQQQQALAA 128

Human    44 AHA------TSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQI 102
            |.|      .:..|..|::....|..|||...|....|..|: |:..|
  Fly   129 ATAMQKVVYVAKPPNSTVIHTTPGNAVQVRNKIPPTFPCKIK-PEPNT----------------- 175

Human   103 STIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITT 167
               ...|||.||: |..|||..|..|:|||||.||..                   |.|.|.::.
  Fly   176 ---QHPEDSDESL-SDDDSQHHRSELTRRPSYNKIFT-------------------EISGPDMSG 217

Human   168 VTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQ 232
            .::|.                         :|||...| |..|.|......::::|.
  Fly   218 ASLPM-------------------------SDGVLNSQ-LAGTGAGGNAANSSLMQL-------- 248

Human   233 ILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAA 297
                           |...|.......:|...|:            ||:..||||:||.||||||
  Fly   249 ---------------DPTYYLSNRMSYNTNNSGI------------AEDQTRKREIRLQKNREAA 286

Human   298 RECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCH-KSD 341
            ||||||||||:|||||||||||||||.||||||:||:|||. |:|
  Fly   287 RECRRKKKEYIKCLENRVAVLENQNKALIEELKSLKELYCQTKND 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CREB1	NP_001358355.1	pKID	113..151	CDD:396650	15/37 (41%)
		bZIP_CREB1	285..339	CDD:269838	47/54 (87%)
		coiled coil	286..337	CDD:269838	44/50 (88%)
CrebB	NP_001334685.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144426
Domainoid	1	1.000	100	1.000	Domainoid score	I7018
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	152	1.000	Inparanoid score	I4360
Isobase	1	0.950	-	0	Normalized mean entropy	S6446
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D407205at33208
OrthoFinder	1	1.000	-	-		FOG0001658
OrthoInspector	1	1.000	-	-		otm40992
orthoMCL	1	0.900	-	-		OOG6_107251
Panther	1	1.100	-	-	O	PTHR45879
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	1	1.000	-	-		X1385
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.970