DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ephb6 and Eph

DIOPT Version :9

Sequence 1:	XP_030111004.1	Gene:	Ephb6 / 13848	MGIID:	1096338	Length:	1078	Species:	Mus musculus
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	1152	Identity:	366/1152 - (31%)
Similarity:	564/1152 - (48%)	Gaps:	211/1152 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 SRVVAGMVCSLWLLVLGSSV-----LALEEVLLDTTGETSEIGWLTYPPG------GWDEVSVLD 64
            |::|:.|.....:|::..|:     .|.:.||||||.|.: :.|..||.|      ||.|.|..|
  Fly    56 SQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREAT-LEWTRYPYGPQAQTPGWVEESFTD 119

Mouse    65 DQRRLT-RTFEACHVAGLPPGSGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRET 128
            ..:.:. |::..|.||    ....:|||.:.|::|..|.|.:|.:.|::|.||....:..:|:||
  Fly   120 FVKGINWRSYVVCDVA----YHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKET 180

Mouse   129 FTLYYRQAD----EPDGPDSIAAWHLKRWTKVDTIAADESFPASSSSSSWAVGPHRTGQRVGLQL 189
            |:|.:.:.|    ||      ..|....:..:..|||.|.               |..|...:.:
  Fly   181 FSLLFYEFDAATREP------PPWQTDSYRLIARIAAGEG---------------RFNQNSDVDI 224

Mouse   190 NVKERSFGPLTQRGFYVAFQDTGACLALVAVKLFSYTCPSVLRAFASFPETQASGAGGASLVAAV 254
            |.:.:|.. :.::|.|.||:|.|||::::|||::..|||:|...||.|.|| .:|.....:....
  Fly   225 NTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNET-PTGREITIIEKQN 287

Mouse   255 GTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGRWMVAVGGCRCQPGHQPARGDKLCQACPEGSYKA 319
            ||||.:|||.|          .|...|.|:|:|.:..|||||:.|::|...:|.|..||.|::|:
  Fly   288 GTCVDNAEPYE----------TPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKS 342

Mouse   320 LAGNVP----CSPCPARSHSPDPAAPVCPCLQGFYRASSDPPEAPCTGPPSAPRE--LWFEVQGS 378
                 |    |:|||..|::....:|.|.|..||||..:|....||..||:||..  |.|..|.|
  Fly   343 -----PEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTS 402

Mouse   379 ALMLHWRLP-------QELGGR---GDLLFNVVCKECGGHGEPSSGGMCRRCRDEVHFDPRQRGL 433
            |: :.|..|       .|...:   .|:::.:               .|..|...|.::|.....
  Fly   403 AI-ISWSAPAKNESFSSETNSKIYHSDIVYKI---------------KCNICSPNVVYNPSTDTF 451

Mouse   434 TESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEGELFSFSLRTACFSSSDPL 498
            .|:::.:..|.....|.:::.|:|.||.          ||....|..|....::....||::. |
  Fly   452 NETKITLTNLEPVTTYTVQIHAINSVSH----------INEFKRHSNESSLVAVSDIVFSNTS-L 505

Mouse   499 FPMPDFQPACIRHLILNSIPSTLGCCCLQRLQTPPPNNNPPPCTLVPSAVPVMHQVSRAAN---- 559
            ..:|         |.||.:.:                   ....:|.:...|:  :|...|
  Fly   506 LNIP---------LDLNEVKT-------------------GQAEIVFTTESVL--LSTVFNLRIL 540

Mouse   560 SIT-----VSWPQPEQTNGNILDYQLRYYDQAE-DESHSFTMTSETNTATVTRLSPGHIYGFQVR 618
            :||     :.|.:|.|::..:..|::|::.:.| |..:...:.::...|.:..|.....||||||
  Fly   541 AITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVR 605

Mouse   619 ARTAAGHGPYGGKVYFQTLPQGELSSQLPEKLSL--VIGSILGALAFLLLAAITVLAVIFQRK-- 679
            .:|..|.|.|...:|.|||.  .:.|...:.:.:  :.|:|:..:.||::  ..:..|.|.|.
  Fly   606 CKTNNGFGSYSNMIYAQTLQ--SVGSVYDDSVQIRFIAGAIVTGVLFLVI--FIIATVYFMRSKH 666

Mouse   680 -----RRGTGYTEQLQQYSS---------------------PGLG-VKYYIDPSTYDDPCQAIRE 717
                 ::.|.:......|:|                     |..| .:.|:||.||:||.|||||
  Fly   667 QDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIRE 731

Mouse   718 LAREVDPTYIKIEEVIGAGSFGEVRRGRLQ--PRGRREQAVAIQALWAGGAESLKMTFLGRAALL 780
            .|||:|..||.||.:||.|.||:|.||||:  |...::..|||:.|..|.:|..:..||..|:::
  Fly   732 FAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIM 796

Mouse   781 GQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSS 845
            |||.|||::.|:||||:|.|||::||.||.|.||:|||..:|:|.:|||:.|.||:|:.|.|||.
  Fly   797 GQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSD 861

Mouse   846 FAFVHRALSARSVLVNSHLVCKVARLG-----------HSPQGSSSLLRWAAPEVITHGKYTTSS 899
            ..:|||.|:||:||||:.|:||:|..|           ::.:|....:||.|||.|...|:|::|
  Fly   862 MNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSAS 926

Mouse   900 DVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPH 964
            ||||:|:::||||||||||||:.:.|:|:.:||:.:|||.|..||..|:.||||.|||.|..||.
  Fly   927 DVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPT 991

Mouse   965 FDQLVAAFDKMIRKPDTL-------QAEGG---SGDRPSQALLNPVALDFPCLDSPQAWLSAIGL 1019
            |..:|:..|.:.|:|.:|       :::|.   .|.|.....:           |...||..|.:
  Fly   992 FASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFI-----------STDLWLEHIKM 1045

Mouse  1020 ECYQDNFSKFGLSTFSDVAQLSLEDLPGLGITLAGHQKKLLHNIQLL 1066
            ..|..:|.:..|.....:::|:.:.|..:||||.|||||:||..:.|
  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephb6	XP_030111004.1	EphR_LBD_B6	34..226	CDD:198443	60/202 (30%)
		Ephrin_rec_like	305..340	CDD:311571	12/38 (32%)
		fn3	366..464	CDD:365830	22/109 (20%)
		FN3	545..636	CDD:238020	25/100 (25%)
		EphA2_TM	669..722	CDD:373140	22/81 (27%)
		PKc_like	722..976	CDD:389743	129/266 (48%)
		SAM_EPH-B6	1002..1070	CDD:188954	21/65 (32%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	60/201 (30%)
		FN3	387..476	CDD:238020	20/104 (19%)
		FN3	536..623	CDD:238020	23/86 (27%)
		EphA2_TM	644..736	CDD:291255	25/93 (27%)
		PTKc_EphR	736..1002	CDD:270629	129/265 (49%)
		Pkinase_Tyr	741..999	CDD:285015	126/257 (49%)
		SAM_1	1033..1092	CDD:278937	20/69 (29%)
		SAM	1039..1092	CDD:197735	19/52 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5665
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	760	1.000	Inparanoid score	I548
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770