DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ephb2 and Eph

DIOPT Version :9

Sequence 1:	XP_006538597.1	Gene:	Ephb2 / 13844	MGIID:	99611	Length:	988	Species:	Mus musculus
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	1057	Identity:	445/1057 - (42%)
Similarity:	609/1057 - (57%)	Gaps:	126/1057 - (11%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 LAAVEETLMDSTTATAELGWMVHP------PSGWEEVSGYD--ENMNTIRTYQVCNVFESSQNNW 72
            ||..::.::..||..|.|.|..:|      ..||.|.|..|  :.:|. |:|.||:|...:.|||
  Fly    79 LAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINW-RSYVVCDVAYHNVNNW 142

Mouse    73 LRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDLATKTFPNWMENPWVK 137
            |.:.||.|..|:|:::|::|::||||..|....||||||:|.:||  ||.||:..|.|..:.:..
  Fly   143 LWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYE--FDAATREPPPWQTDSYRL 205

Mouse   138 VDTIAADES-FSQ---VDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKCP 198
            :..|||.|. |:|   ||       |||||:|.. |::.|.|.||:|.|.|:|::||:|:|..||
  Fly   206 IARIAAGEGRFNQNSDVD-------INTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCP 262

Mouse   199 RIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAV 263
            .:.:|.|.|.||.:|.|.|.:....|:|:.|||..:.|..| |.|||:|.:..|.|.||||:|..
  Fly   263 AVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYL-CKGDGKWTILTGGCRCKAGYEPN 326

Mouse   264 ENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAP 328
            .....|..||.||||:.:..: ||.||.||..:..|:..|.|.:|:||...|...|||.:.|:||
  Fly   327 YTNKTCTECPLGTFKSPEVTK-CTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAP 390

Mouse   329 -QAVISSVNETSLMLEWTPP--RDSGGRE--------DLVYNIICKSCGSGRGACTRCGDNVQYA 382
             ...:..|::||.::.|:.|  .:|...|        |:||.|          .|..|..||.|.
  Fly   391 TNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----------KCNICSPNVVYN 445

Mouse   383 PRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQF----------------------- 424
            |......|.:|.:::|...|.||.:|.|:|.|:..:.|....
  Fly   446 PSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPL 510

Mouse   425 ---------ASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKQELS 480
                     |.:..||.....|.|..:..::.|.....|.|.:|.|.:..:..||::::.|.||.
  Fly   511 DLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELD 575

Mouse   481 EYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTE--AEYQTSIKEKLP 543
            ..|.:|:.:......:.||.....|.||||.:|..|:|.||..:|.||:..  :.|..|:  ::.
  Fly   576 AINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSV--QIR 638

Mouse   544 LIVGSSAAGLVFLIAVVVIAIVCNRRRGFERADSEYTDKLQ---HYTSGHM-----TPGMK---- 596
            .|.|:...|::||:..::..:...|.:..:..|.:.|:.|.   .|.|..:     ||.:|
  Fly   639 FIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHL 703

Mouse   597 -----------IYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGK--R 648
                       .|:||.||||||:|:||||:|||.:.:.||.:||.||||:||.|.||:|..  :
  Fly   704 NVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQ 768

Mouse   649 EIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL 713
            :|.|||||||.|.:||.|.|||:||||||||||||||:|:||||:|.|||||||:|||||||:||
  Fly   769 DIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFL 833

Mouse   714 RQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS 778
            |.|||:|..:||:.||||||:||.||:|||||||||||||:|||:.|:||::||||||.:| :.|
  Fly   834 RVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIE-NAS 897

Mouse   779 DPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQ 843
            | .||:. |||||:||||||||.:|||||||||||||:|:||||||||||||:.:|||||.:||:
  Fly   898 D-AYTTR-GGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEK 960

Mouse   844 DYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLD 908
            .||||.|||||.||:|||||||||.|.|||.|..||:|||.:.|.|.||....|........:||
  Fly   961 GYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILD 1025

Mouse   909 ----RTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKI 969
                :.|     |.:.|.|||.|||.:|...|..|...:...:|::..:.:..:|:||.||||||
  Fly  1026 GQRGQNI-----FISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKI 1085

Mouse   970 LNSIQVMRAQMNQIQSV 986
            |:       |..|:.::
  Fly  1086 LH-------QARQLDTI 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephb2	XP_006538597.1	EphR_LBD_B2	19..196	CDD:198445	75/188 (40%)
		fn3	326..419	CDD:365830	29/103 (28%)
		fn3	437..520	CDD:365830	24/82 (29%)
		EphA2_TM	549..618	CDD:373140	26/91 (29%)
		PTKc_EphR_B	618..886	CDD:173638	190/269 (71%)
		SAM_EPH-B2	912..982	CDD:188951	23/69 (33%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	75/185 (41%)
		FN3	387..476	CDD:238020	28/98 (29%)
		FN3	536..623	CDD:238020	25/86 (29%)
		EphA2_TM	644..736	CDD:291255	26/91 (29%)
		PTKc_EphR	736..1002	CDD:270629	190/268 (71%)
		Pkinase_Tyr	741..999	CDD:285015	185/260 (71%)
		SAM_1	1033..1092	CDD:278937	23/65 (35%)
		SAM	1039..1092	CDD:197735	21/59 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I745
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	760	1.000	Inparanoid score	I548
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		otm44283
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740