DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Epha8 and Eph

DIOPT Version :9

Sequence 1:NP_031965.2 Gene:Epha8 / 13842 MGIID:109378 Length:1004 Species:Mus musculus
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:1045 Identity:412/1045 - (39%)
Similarity:574/1045 - (54%) Gaps:132/1045 - (12%)


- Green bases have known domain annotations that are detailed below.


Mouse    30 EVNLLDTSTIHGDWGWLTYP------AHGWDSINEVDESFRPI------HTYQVCNVMSPNQNNW 82
            :|.|||| |......|..||      ..||     |:|||...      .:|.||:|...|.|||
  Fly    84 QVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFTDFVKGINWRSYVVCDVAYHNVNNW 142

Mouse    83 LRTNWVPRDGARRVYAEIKFTLRDCNSIPGVLGTCKETFNLHYLESDRDLGASTQE------SQF 141
            |.:.::.|..|.|:|.||:||:|||:..||...:|||||:|.:.|.|    |:|:|      ..:
  Fly   143 LWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFD----AATREPPPWQTDSY 203

Mouse   142 LKIDTIAADESFTGADLGVRRLKLNTEVRGVGPLSKRGFYLAFQDIGACLAILSLRIYYKKCPAM 206
            ..|..|||.|.....:..|   .:||||:.:. ::|:|.|.||:|.|||:::|::::||..|||:
  Fly   204 RLIARIAAGEGRFNQNSDV---DINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAV 264

Mouse   207 VRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERDTPKMYCSAEGEWLVPIGKCVCSAGYEER--R 269
            ..|.|.|:|..||.:.:.:.:..|.||.::|..:||...|..:|:|.:..|.|.|.||||..  .
  Fly   265 TENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTN 329

Mouse   270 DACMACELGFYKSAPGDQLCARCPPHSHSATPAAQTCRCDLSYYRAALDPPSAACTRPPSAPVNL 334
            ..|..|.||.:|| |....|..|||:|:::...:..|:|...:||...|.....|..||:||.||
  Fly   330 KTCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNL 393

Mouse   335 -ISSVNGTSVTLEWAPPLDPGG----------RSDITYNAVCRRCPWALSHCEACGSGTRFVPQQ 388
             :..|:.||..:.|:.|.....          .|||.|..          .|..|.....:.|..
  Fly   394 TLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI----------KCNICSPNVVYNPST 448

Mouse   389 TSLAQASLLVANLLAHMNYSFWIEAVNGVSNLSPEPR----------------SAAVVNI----- 432
            .:..:..:.:.||.....|:..|.|:|.||:::...|                :.:::||     
  Fly   449 DTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLN 513

Mouse   433 -----------TTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEK-DKEMQS 485
                       ||.....|.|..:|..........|.|.:|.|.:..:..||::::.| :.:..:
  Fly   514 EVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAIN 578

Mouse   486 YSTLKAVTTRATVSGLKPGTRYVFQVRARTSAGCGRFSQAMEVET----GKPRPRYDTRT-IVWI 545
            .|.|....|:|.:.||...|.|.||||.:|:.|.|.:|..:..:|    |..   ||... |.:|
  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSV---YDDSVQIRFI 640

Mouse   546 CLTLITGLVVLLLLLIC-----KKRHCGYSKAFQDSDEEK--------MHYQ----NGQAPPPVF 593
            ...::||::.|::.:|.     :.:|       ||..::|        :.|.    |.....|:.
  Fly   641 AGAIVTGVLFLVIFIIATVYFMRSKH-------QDDLDKKSTNHLPLPLDYASNEVNSMDTTPIV 698

Mouse   594 --LPLNHPPGKFPETQFSAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGESGEVCYGRLQVP 656
              |.||.....|..::...:|||||:|.:|.|.|.|||:|:.|.||.|||.||.|:||.|||::|
  Fly   699 KKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIP 763

Mouse   657 GQ--RDVPVAIKALKAGYTERQRQDFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGS 719
            ..  :|:.||||.||.|.:|:.|.|||:||:|||||||||:|.|:|||||....||:||||||||
  Fly   764 PNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGS 828

Mouse   720 LDAFLRTHDGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRAL 784
            ||.|||.:||:|..:||:.||||:.:||.||||:.|:|||||||||||:.:|:||::||||||.:
  Fly   829 LDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREI 893

Mouse   785 EDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISS 849
            |:..: ||||.|||||:|||||||||||.|:|||||||:|||:|||::||||||||.:|||||.|
  Fly   894 ENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKS 957

Mouse   850 VEEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALVHSPESLRATATVSRCPPPA 914
            :|:||||||||.||.||:|||||||.|.|..||.||.:||.||.|...|:||..|    |..|.:
  Fly   958 IEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTT----RPSPES 1018

Mouse   915 FARSCFDLRAGGSGNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGITLMGH 979
            ......|.:.|  .|..::...||:.|:|.||..||......:...:.|:.||.:..:||||:||
  Fly  1019 DGNHILDGQRG--QNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGH 1081

Mouse   980 QKKIL 984
            |||||
  Fly  1082 QKKIL 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Epha8NP_031965.2 EphR_LBD_A8 30..202 CDD:198454 70/189 (37%)
fn3 329..422 CDD:278470 24/103 (23%)
FN3 439..530 CDD:238020 26/91 (29%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000269|PubMed:17875921 563..569 1/5 (20%)
EphA2_TM <565..629 CDD:291255 21/77 (27%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000269|PubMed:11416136 588..643 24/56 (43%)
PKc_like 629..895 CDD:304357 178/267 (67%)
Pkinase_Tyr 634..891 CDD:285015 174/258 (67%)
SAM_EPH-A8 932..994 CDD:188949 22/53 (42%)
SAM 933..993 CDD:197735 22/52 (42%)
PDZ-binding. /evidence=ECO:0000255 1002..1004
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 70/188 (37%)
FN3 387..476 CDD:238020 22/98 (22%)
FN3 536..623 CDD:238020 24/86 (28%)
EphA2_TM 644..736 CDD:291255 25/98 (26%)
PTKc_EphR 736..1002 CDD:270629 178/266 (67%)
Pkinase_Tyr 741..999 CDD:285015 174/258 (67%)
SAM_1 1033..1092 CDD:278937 22/54 (41%)
SAM 1039..1092 CDD:197735 22/48 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 398 1.000 Domainoid score I745
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 760 1.000 Inparanoid score I548
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm44283
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.880

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