DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epha5 and Eph

DIOPT Version :9

Sequence 1:	XP_006534832.1	Gene:	Epha5 / 13839	MGIID:	99654	Length:	1040	Species:	Mus musculus
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	1087	Identity:	434/1087 - (39%)
Similarity:	606/1087 - (55%)	Gaps:	158/1087 - (14%)

- Green bases have known domain annotations that are detailed below.

Mouse    42 LWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKN------GWEEIGEVDENYAPI-- 98
            |.|.||:..::...||. :::|.|||: |....|.|..:|..      ||     |:|::...
  Fly    65 LRTILLIIISIHFKLAH-ADQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFTDFVK 122

Mouse    99 ----HTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFE 159
                .:|.||.|...|.||||.:.:|....|:|::||::||:|||:..||...:|||||::.::|
  Fly   123 GINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYE 187

Mouse   160 SDDENGRSIKE------NQYIKIDTIAADES-FTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQ 217
            .|    .:.:|      :.|..|..|||.|. |.:    :..:.:||||:.:. ::|||.|.||:
  Fly   188 FD----AATREPPPWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFR 243

Mouse   218 DVGACIALVSVRVYYKKCPSVVRHLAIFPDTITGADSSQLLEVSGSCVNHSVTDDPPKMHCSAEG 282
            |.||||::::|:|||..||:|..:.|.|.:|.||.:.:.:.:.:|:||:::...:.|...|..:|
  Fly   244 DQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDG 308

Mouse   283 EWLVPIGKCMCKAGYEEK--NGTCQVCRPGFFKASPHSQTCSKCPPHSYTHEEASTSCVCEKDYF 345
            :|.:..|.|.||||||..  |.||..|..|.|| ||....|:.|||:|...:..|..|.|...::
  Fly   309 KWTILTGGCRCKAGYEPNYTNKTCTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFY 372

Mouse   346 RKDSDPPTMACTRPPSAPRN-AISNVNETSVFLEWIPPA-------DTGGR---KDVSYYIACKK 399
            |..:|...|.|..||:||.| .:..|::||..:.|..||       :|..:   .|:.|.|   |
  Fly   373 RHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI---K 434

Mouse   400 CNSHAGVCEECGGHVRYLPQQIGLKNTSVMMVDLLAHTNYTFEIEAVNGVS-------------- 450
            ||.       |..:|.|.|.......|.:.:.:|...|.||.:|.|:|.||
  Fly   435 CNI-------CSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSL 492

Mouse   451 ------------------DLSPGTRQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRP 497
                              ||:........:..||.....|.|.|::...|......|.|.:|.:.
  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557

Mouse   498 NGIILEYEIKYFEKDQ--ETSYTIIKSKETSITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFE 560
            :..:..||:::|.|.:  ..:.:.:.:|||.....||...:.|.||:|.:|..|:|.:|.....:
  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622

Mouse   561 TTPVSVAASNDQSQIPIIAVSVTVGVILLAVMIGFLLSGSCCDCGCGRASSLCAVAHPSLIWRCG 625
            |.....:..:|..||..||.::..||:.|.:.|                           |....
  Fly   623 TLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFI---------------------------IATVY 660

Mouse   626 YSKAK-QDPEEEKMHFHNGHIKLP------------------------------GVRTYIDPHTY 659
            :.::| ||..::|   ...|:.||                              ..|:|:|||||
  Fly   661 FMRSKHQDDLDKK---STNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTY 722

Mouse   660 EDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGK--RELPVAIKTLKVGYTEKQRR 722
            ||||||:.|||:||:|:.||||.:||.||||:||.||||:|..  :::.|||||||.|.:||.|.
  Fly   723 EDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARC 787

Mouse   723 DFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 787
            |||.||||||||||||:|:|:||||:|.||||:|||||||||||||:.|||:|..:||:.|||||
  Fly   788 DFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGI 852

Mouse   788 AAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEA 852
            |:||.|||||.||||||||||:|:|:.|:||::||||||.:|:..: ||||||||||:|||||||
  Fly   853 ASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEA 916

Mouse   853 IAFRKFTSSSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC 917
            ||||||||:|||||||:|:|||:||||||||..:||||||::|:|||||:|||||.|||||||||
  Fly   917 IAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDC 981

Mouse   918 WQKDRNSRPKFDEIVNMLDKLIRNPSSLKTLVNASSRVSTLLAEHGSLGSGAYRSVGEWLEAIKM 982
            |||.|..||.|..||:.||.|.|.|.||.|...:.......:.: |..|...:.|...|||.|||
  Fly   982 WQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILD-GQRGQNIFISTDLWLEHIKM 1045

Mouse   983 GRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMSSLQEM 1029
            .||...|.|....:...::::|.:.|..:|:|||||||||:...:::
  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epha5	XP_006534832.1	EphR_LBD	62..234	CDD:383093	67/190 (35%)
		FN3	360..466	CDD:238020	33/148 (22%)
		FN3	471..561	CDD:238020	24/91 (26%)
		EphA2_TM	581..673	CDD:373140	28/122 (23%)
		PTKc_EphR_A	673..939	CDD:270651	191/267 (72%)
		SAM_EPH-A5	968..1033	CDD:188945	23/62 (37%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	67/189 (35%)
		FN3	387..476	CDD:238020	28/98 (29%)
		FN3	536..623	CDD:238020	22/86 (26%)
		EphA2_TM	644..736	CDD:291255	28/121 (23%)
		PTKc_EphR	736..1002	CDD:270629	191/266 (72%)
		Pkinase_Tyr	741..999	CDD:285015	187/258 (72%)
		SAM_1	1033..1092	CDD:278937	23/58 (40%)
		SAM	1039..1092	CDD:197735	22/52 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	398	1.000	Domainoid score	I745
eggNOG	1	0.900	-	-		E2759_KOG0196
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.830