DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Epha3 and Eph

DIOPT Version :9

Sequence 1:NP_034270.1 Gene:Epha3 / 13837 MGIID:99612 Length:984 Species:Mus musculus
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:1075 Identity:425/1075 - (39%)
Similarity:607/1075 - (56%) Gaps:146/1075 - (13%)


- Green bases have known domain annotations that are detailed below.


Mouse     5 LSILVLLGCCVLSCSGELSPQPSNEVNLLDSKTIQGELGWISYP------SHGWEEISGVDEHYT 63
            :|:|..:...::|...:|:  .:::|.|||: |.:..|.|..||      :.||     |:|.:|
  Fly    62 MSLLRTILLIIISIHFKLA--HADQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFT 118

Mouse    64 PI------RTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNL 122
            ..      |:|.||:|..|:.||||.:.::.|.||.::|:|::||:|||:..|....:|||||:|
  Fly   119 DFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSL 183

Mouse   123 YYMESDDDHGVKFRE------HQFTKIDTIAADES-FTQMDLGDRILKLNTEIREVGPVNKKGFY 180
            .:.|.|    ...||      ..:..|..|||.|. |.|    :..:.:|||::.:. |||||.|
  Fly   184 LFYEFD----AATREPPPWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVY 239

Mouse   181 LAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVR-GSCVNNSKEEDPPRMYC 244
            .||:|.|||:::::|:||:..||...:|.|.|.:|......:::|.: |:||:|::..:.|...|
  Fly   240 FAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLC 304

Mouse   245 STEGEWLVPIGKCTCNAGYEER--GFICQACRPGFYKASDGAAKCAKCPPHSSTQEDGSMNCRCE 307
            ..:|:|.:..|.|.|.||||..  ...|..|..|.:|:.: ..||..|||:|:..:.||..|:|.
  Fly   305 KGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPE-VTKCTPCPPNSNASKTGSPFCKCA 368

Mouse   308 NNYFRAEKDPPSMACTRPPSAPRNV-ISNINETSVILDWSWPL-------DTGGR---KDITFNI 361
            :.::|...|...|.|..||:||.|: :..:::||.|:.||.|.       :|..:   .||.:.|
  Fly   369 SGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI 433

Mouse   362 ICKKCGWNVRQCEPCSPNVRFLPRQLGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQ-- 424
                      :|..|||||.:.|.......|.:|:|:|...|.||.:|.|:|.||.::...|.  
  Fly   434 ----------KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSN 488

Mouse   425 ------------------------------YAAVSITTNQAAPSPVMTIKKDRTSRNSISLSWQE 459
                                          .|.:..||.....|.|..::....:.....|.|.:
  Fly   489 ESSLVAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDK 553

Mouse   460 PEHPNGIILDYEVKYYEKQEQET-SYTILRARGTNVTISSLKPDTTYVFQIRARTAAGYGTNSRK 523
            |...:..:..|||:::.|.|.:. :.:.|..:.|...|..|..:|.|.||:|.:|..|:|:.|..
  Fly   554 PVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNM 618

Mouse   524 FEFETSPDSFSISGENSHVVMIAISAAVAIIVLTVVTYVLVGRFCGYHKSKHSAE---------- 578
            ...:|.....|:..::..:..||  .|:...||.:|.:::...:  :.:|||..:          
  Fly   619 IYAQTLQSVGSVYDDSVQIRFIA--GAIVTGVLFLVIFIIATVY--FMRSKHQDDLDKKSTNHLP 679

Mouse   579 ------------------EKRLH-------FGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELD 618
                              .|:||       |||.       |:||||||||||.||:.|||:|:|
  Fly   680 LPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNS-------RSYVDPHTYEDPNQAIREFAREID 737

Mouse   619 ATNISIDKVVGAGEFGEVCSGRLKLPSK--KEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP 681
            |..|:|:.::|.||||:||.||||:|..  ::|.|||||||.|.:||.|.|||.|||||||||||
  Fly   738 ANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHP 802

Mouse   682 NIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHR 746
            |:|.|:||||:|.||||:||||||||||:|||.:|.:|..:||:.|||||||||.|||||.||||
  Fly   803 NVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHR 867

Mouse   747 DLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSY 811
            ||||||:|:|:.|:||::||||||.:|:..: ||||||||||:|||:|||||:||||||||||||
  Fly   868 DLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSY 931

Mouse   812 GIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIV 876
            |:||||||||||||||..|||||||::::|||||.|||||.||||||||||||.|.:||.|..||
  Fly   932 GVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIV 996

Mouse   877 SILDKLIRNPGSLKIITSAAARPSNLLLD-QSNVDIATFHTTGDWLNGMRTAHCKEIFTGVEYSS 940
            |.||.|.|.|.||.....:.....|.:|| |...:|  |.:|..||..::.:.....|......:
  Fly   997 STLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNI--FISTDLWLEHIKMSRYCHHFKEANLIN 1059

Mouse   941 CDTIAKISTDDMKKVGVTVVGPQKKIISTIKALET 975
            ...|::::...:..:|:|:||.||||:...:.|:|
  Fly  1060 AQQISRLTAQQLSDMGITLVGHQKKILHQARQLDT 1094

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Epha3NP_034270.1 EphR_LBD_A3 29..201 CDD:198449 70/190 (37%)
fn3 327..417 CDD:278470 31/100 (31%)
FN3 437..528 CDD:238020 23/91 (25%)
EphA2_TM <566..617 CDD:291255 25/85 (29%)
PTKc_EphR_A 617..883 CDD:270651 190/267 (71%)
Pkinase_Tyr 622..879 CDD:285015 186/258 (72%)
SAM 909..976 CDD:197735 17/67 (25%)
SAM_EPH-A3 913..975 CDD:188943 15/61 (25%)
PDZ-binding. /evidence=ECO:0000255 982..984
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 70/189 (37%)
FN3 387..476 CDD:238020 30/98 (31%)
FN3 536..623 CDD:238020 21/86 (24%)
EphA2_TM 644..736 CDD:291255 28/100 (28%)
PTKc_EphR 736..1002 CDD:270629 190/266 (71%)
Pkinase_Tyr 741..999 CDD:285015 186/258 (72%)
SAM_1 1033..1092 CDD:278937 14/58 (24%)
SAM 1039..1092 CDD:197735 12/52 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 398 1.000 Domainoid score I745
eggNOG 1 0.900 - - E2759_KOG0196
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 760 1.000 Inparanoid score I548
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm44283
orthoMCL 1 0.900 - - OOG6_100189
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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