DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epb42 and Tg

DIOPT Version :9

Sequence 1:	NP_038541.1	Gene:	Epb42 / 13828	MGIID:	95402	Length:	691	Species:	Mus musculus
Sequence 2:	NP_609174.1	Gene:	Tg / 34093	FlyBaseID:	FBgn0031975	Length:	776	Species:	Drosophila melanogaster

Alignment Length:	713	Identity:	194/713 - (27%)
Similarity:	324/713 - (45%)	Gaps:	59/713 - (8%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 LSIKSCDFHAAENNEEHYTK----AISSQHLTLRRGQSFTITLNFR---APTHTFLSALKKVALI 62
            |.:...|....:|:|||:|.    |.:.:.|.:|||:.|.:.::|.   :|:...:|.:..||
  Fly    54 LGVLKVDLCLEDNHEEHHTSHFYAAAAKEALVVRRGEPFRLKIHFNRDYSPSKDAISFIFTVA-- 116

Mouse    63 AQTGEQPSKINKT-QAIFP---ISSLGDQKGWSAAVEERDAQHWTVSVTTPVDAVIGHYSLLLQV 123
              ...:||..:.| .|:.|   |..|||...|.|.:|..:.|..||.:..|....:..:.|.:..
  Fly   117 --DDTKPSPGHGTLNALVPHDGIDYLGDTLEWGAGIESHEGQTLTVLIKPPSTCPVTEWKLDIDT 179

Mouse   124 ----SGKKQYPLG-QFTLLFNPWNRDDAVFLQNEAERTEYVLNQNGFIYLGTADCIQEEPWDFGQ 183
                .|.:.|||. ...:|||||..||.|:|::..:|.|||::....|:.|:.:.::...|..||
  Fly   180 KLLGDGSRSYPLPLPIYVLFNPWCPDDQVYLEDRDQRKEYVMHDTTLIWRGSYNRLRPSVWKIGQ 244

Mouse   184 FEKDVMDLSLKLLSMDKQVKD--WNQPAHVARVVGALLHALKKKSVLPISQTQAAQEGALLYKRR 246
            ||:.|::.|||:|....::..  ...|..|||.:.||::::....||..:.::....|....|..
  Fly   245 FERHVLECSLKVLGTVGRIPPAYRGDPVRVARALSALVNSVDDDGVLLGNWSEDFSGGVAPTKWT 309

Mouse   247 GSVPILRQWLTGQGRAVYETQAWVSAAVACTVLRCLGIPARVVTTFDSAQGTVGSLLVDEYYNEE 311
            |||.||:|:...| ::|...|.|..:.|..|:.|.||||:|::|.:.||..|..||.||.:.:..
  Fly   310 GSVEILQQFYKTQ-KSVKFAQCWNFSGVLTTIARSLGIPSRIITCYSSAHDTQASLTVDVFIDAN 373

Mouse   312 GLQNGEGQRGHIWVFQTSVECWMNRPDLSQG----YGGWQILHPRAPNGAGVLGSCSLVPVRAVK 372
            ..:........||.:....|.||.||||..|    :.|||::.......:..:.......|.|||
  Fly   374 NKKLDAETTDSIWNYHVWNELWMQRPDLGVGEHGTFDGWQVVDATPQEASDNMYRVGPASVAAVK 438

Mouse   373 EGELQLDPAVPELFAAVNASCVVWKCCEDGKLELTNSNRKD---VGNCISTKVVGSDRCEDITQN 434
            .|::........:||.|||..:.|:  .:|..:.....|||   :|:.||||.|.....||||..
  Fly   439 NGDILRPFDGGFVFAEVNADKLYWR--YNGPSQPLKLLRKDTLAIGHLISTKAVLKWEREDITDT 501

Mouse   435 YKYPAGSLQEKEVLEKVQKE------RLKLGKDNGMCPPSCEPWDPLHMFFEASSSIPLSGDGQ- 492
            ||:...|.:|:..:.|..|:      |..| .||         ::.:....|....|.:   ||
  Fly   502 YKHAERSEEERSTMLKALKQSRHAFSRYYL-NDN---------FNDIEFDMELKDDIKI---GQS 553

Mouse   493 LSVTLINPTDEEKKVHLVIG---AQALYYNGVLAAGLWSKKQLFMLKPNQVMRLSTNLSFSCFEQ 554
            .||.|......|.:.|:..|   ..|:.|.||.|..:.:......|:|.....:...:.|..:..
  Fly   554 FSVVLKVSNKSESRTHMATGQISCDAVLYTGVGAVEVKTLGFELELEPKSSDYVRMEVIFEEYYD 618

Mouse   555 TPPENSFLRVTAMARYSHTSLSCFAQENMAIGKPDLIIEMPKRA--AQYRPLTVSVRMHNSLEAP 617
            .....:..:::|.|:...|....:||::..:.|||:..::.:.|  || :.|.|.:|:.|.|..|
  Fly   619 KLSSQAAFQISAAAKVKDTDYDYYAQDDFRVRKPDIKFQLGEAAIVAQ-KELDVILRLENPLPIP 682

Mouse   618 MQNCIISIFGRGLIHREKRYGLGSLWPGSSLHTQFQFTPTHLGLQRLTVEVDCDMFQNLTGYR 680
            :...:.::.|.| |.:..::.:..:..|.:....|::||.:.|...:..:.......::.|||
  Fly   683 LHKGVFTVEGPG-IEQPLKFKIAEIPVGGTAAATFKYTPPYAGRGTMLAKFTSKELDDVDGYR 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epb42	NP_038541.1	Transglut_N	6..123	CDD:279240	34/127 (27%)
		Band 3 binding. /evidence=ECO:0000250	31..39		4/7 (57%)
		TGc	261..351	CDD:214673	32/93 (34%)
		Transglut_C	475..573	CDD:279295	20/101 (20%)
		Transglut_C	588..686	CDD:279295	22/95 (23%)
Tg	NP_609174.1	Transglut_N	56..179	CDD:279240	34/126 (27%)
		TGc	324..419	CDD:214673	32/94 (34%)
		Transglut_C	538..644	CDD:279295	21/108 (19%)
		Transglut_C	652..750	CDD:279295	22/95 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850846
Domainoid	1	1.000	50	1.000	Domainoid score	I11569
eggNOG	1	0.900	-	-		E1_2CD5G
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11590
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850