DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epb41l3 and cora

DIOPT Version :9

Sequence 1:	XP_006523675.1	Gene:	Epb41l3 / 13823	MGIID:	103008	Length:	1425	Species:	Mus musculus
Sequence 2:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster

Alignment Length:	1778	Identity:	475/1778 - (26%)
Similarity:	727/1778 - (40%)	Gaps:	551/1778 - (30%)

- Green bases have known domain annotations that are detailed below.

Mouse    94 KLSQRSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDY 158
            |...:||||...:..|          .:|||||||.....:|:::.|:.:.:.:|..|||:||||
  Fly    18 KSKPKSSSSSHGKPAL----------ARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDY 72

Mouse   159 FGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVS 223
            |||||....:.:.|||..|.:.|..|:..|..:|.||||||:|:||.||||||:||||:|:||:.
  Fly    73 FGLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILE 137

Mouse   224 GRLPCSFVTLALLGSYTVQSELGDYDPDEC-GNDYISEFRFAPNHTKELEDKVIELHKSHRGMTP 287
            |||||:|||.||||||.||||:||||.:|. ...|:.:|:.|||.|.||||||::|||:|:|.:|
  Fly   138 GRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSP 202

Mouse   288 AEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKR 352
            ||||:|:|||||||:|||||||.|||||||:|||||||||||:|||:||||||||||:|||||||
  Fly   203 AEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKR 267

Mouse   353 NNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPE--APPKKFLTLGSKFR 415
            ::||||||||||||:||||||||.||||||:|||.||||||||||:.||  :..|.|...||.:|
  Fly   268 HHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYR 332

Mouse   416 YSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVSENHEIYMKDSV----------- 469
            |.|||||::  .:..:||..|.|.|:.|.....|||:|..:::|..::..|.|.
  Fly   333 YKGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADG 395

Mouse   470 SAAEVGTGQYATTKGISQTNLITTVTPEKKAEEERVEEEDR----RKKAEEATPV---------- 520
            .|......:....|...:...:.....::|.|:||.|.|.|    :||||:|...
  Fly   396 DAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAALAAGAAAGA 460

Mouse   521 ----------------------------------------------------------------- 520

  Fly   461 AVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSGLG 525

Mouse   521 -------------TALRHEGKSPPG-----HGAADSCPPSPPSAHPDPPPPTELRRRCKEKERAE 567
                         .|.::.|.:.||     ..|.|:...:.|:.....|......:        :
  Fly   526 DNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYDQ--------D 582

Mouse   568 PSSLESEAQGKAYLGDQD------VAFSYRQPAGKGTTLFSFSLQLPESFPSLLDEDGYLSFP-- 624
            |:|.:|.|.|:..|....      :||:| .|..:..        |.|:...|  :.|.|| |
  Fly   583 PNSRKSGADGQEQLSPTSQQKKIGLAFNY-APGNENA--------LKETAEKL--KAGQLS-PRT 635

Mouse   625 --NLSETNLLPQSWQHFL--PIRSP-------------SLLPCFLFIFFFLLSASFSVPYALT-- 670
              .|:...|.|:|....|  |:.||             :.:|         ||.|....|:.|
  Fly   636 QDKLNRGQLSPKSRAKLLQDPLLSPTTRAKLQGSAVDAAAVP---------LSDSQKRSYSPTKG 691

Mouse   671 --------------LSFPLALCL---------CYLEPKAASLSASLDNDPSDSSEEETDSERTDT 712
                          :|.|.|..|         .|:.|..|.::|.|..  :..|::.....:|..
  Fly   692 PQGYSSGAPGSYKPISDPTADFLESQRYNKEPGYVGPSKADVAAGLAG--AAGSKKPGSPTKTGK 754

Mouse   713 AADGETSATESDQEEDAEIKAQ---------------NSLIKRIKGENVYVKHSNLMLEDLDKTQ 762
            .|.|..:|..:.....|...|:               :...|||..||..::||..:|:    ..
  Fly   755 GAPGAAAAAAAGAAGAAAAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILD----PA 815

Mouse   763 DELMKHQTNISELKRTFLET-STETALTNEWEKRL--STSPVRLAARQEDAPMIEPLVPEETKEE 824
            ..|:..:..:.:.|:..||. :|:|.....::..:  .|..:.|.:...|        |:..:.:
  Fly   816 TGLIDTKYGVIDPKKGTLEALNTKTGKKEVFQGDVDGKTGNLHLVSGVAD--------PKTGRLD 872

Mouse   825 REISEKVVFLQQGSSPFLESQPSVTEKTQEGVSADSVATTHQIIFQKTVPSTLEGTEDWVIVD-- 887
            ..:.:.|....|.:        .|.|.|              :|..:..|:|  |..|.|..|
  Fly   873 DTLGQIVCITPQDN--------PVVELT--------------VITSRIDPAT--GKIDTVNGDVE 913

Mouse   888 ------------------KIPT-----EVVDGDSKKIVTYKVVTVSSKTGEI------------- 916
                              :|.|     :.:|..|.|||..|.|.|...||:|
  Fly   914 RSLGVLNLDTGLLDTKYGEINTRTGELKAIDPKSGKIVVSKNVKVDPGTGQITILGIVDPKTNKI 978

Mouse   917 ---PADLLKSGMMDMHGFDDLTREMQL--KEENKQKIY--------TLGKSYDTVSGRIVTMTGK 968
               ...|::.|..    .|.:.....|  |.::|:.|.        |.|..:|..:|:|.|..|:
  Fly   979 DPNQGRLIEVGQQ----IDPIVEVTSLAGKFDSKRNIIDPKTAQVETSGGQFDPKAGKIDTKYGQ 1039

Mouse   969 A---------KDGEKGPQLSTLEGLQKMERGASEAV---RVGP----------LLVEYEVLEALT 1011
            .         .|.:.|   .|:....|:|....:.|   :|.|          .::...:::...
  Fly  1040 IDLVKHTITFNDPKSG---KTVTRDIKIEPTTGQIVLKNQVNPKNNKPDKDYARIISLRIVQQRV 1101

Mouse  1012 DEKSRRAP--EVQTPKRR---------------------------LSESLAP------------- 1034
            | .:.:||  ||...|.:                           :|.|:.|
  Fly  1102 D-PATKAPITEVSASKDKDIVVDPKSNQIWVPTGATDPATKEQQYISSSVDPKTGYVITIYGYLD 1165

Mouse  1035 IKEAESRRQSPEEDDTQK-APKLG---------DYAPAHPQFSKTQQEPE-----CKVLKVGP-- 1082
            .|..|.::|:..:.:|.| .|..|         |.|...|.::.||.:||     .|:.:|.|
  Fly  1166 PKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQATGEPLYAATQVDPESGEVYTKLARVDPKT 1230

Mouse  1083 ---------------------------------FGPRRKSLSEWRY----------------SHE 1098
                                             .|...|..::..|                .::
  Fly  1231 GKIVIVRILLISKTDERGRPEEIDPSTCEIDPVSGRVLKFFNKTVYVYNMIDPVTGEIVQVDPND 1295

Mouse  1099 PAFTVA---TAHYVT------------------------ESSASQVVTKQSSGEKLMDGSEI--- 1133
            |.|..|   ..|.:|                        :...:..||...:|:.:::.::|
  Fly  1296 PRFAGARTTVTHTMTLTGEIDPVTGRIKSEYGDIDPNTGDIDPATAVTDPVTGKLILNYAQIDPS 1360

Mouse  1134 -LSLLESARKPTE--------FIGGVSSTTQSWVQK-----------LETKTEPVEAEVESTPHP 1178
             .......:..||        |..||...::..:::           .:...:.|...:..:|..
  Fly  1361 HFGKQAQVQTTTETVPITRQQFFDGVKHISKGALRRDSEGSSDDDMTAQYGADQVNEILIGSPAG 1425

Mouse  1179 Q-------PLSTEKVLQETILVEERHVMSVHASGDASHTARDEV--------------DAAESTP 1222
            |       |:||..|::.|    .:.|::.:..| .:|...:||              ..|::||
  Fly  1426 QAGGKLGKPVSTPTVVKTT----TKQVLTKNIDG-VTHNVEEEVRNLGTGEVTYSTQEHKADATP 1485

Mouse  1223 TDRRHTGKGKEGSSVT--------EAAKEQRGEEVDQSA--------PEQEQPATVSHEEEQAST 1271
            ||.  :|.....::||        :..|..:.|::::..        |.::|...|:.|.:..:|
  Fly  1486 TDL--SGAYVTATAVTTRTATTHEDLGKNAKTEQLEEKTVATTRTHDPNKQQQRVVTQEVKTTAT 1548

Mouse  1272 IRTSEGLEQKSHFESSTVRVESTSVGSISPGGAKLEISTKEVPVVHTETKTITY-ESSQVDPGAD 1335
            :.:.:..:::....|::.....|.:.....|.:.:....::.|:..|...|..: ||::|..|.|
  Fly  1549 VTSGDQYQRRDSVSSTSSGDSGTPIDGPYDGASVVRTDNQKSPLFTTSATTGPHVESTRVVLGED 1613

Mouse  1336 LEPGV-----LMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDAD-IDHDQALAQA 1394
             .||.     ::|.||::|:|.:..|.|:  ||.:.||.|||:|::|.|..|.| ||||:|||:|
  Fly  1614 -TPGFSGHGEIISTQTVSSKTRTVETITY--KTERDGIVETRVEQKITIQSDGDPIDHDKALAEA 1675

Mouse  1395 IKEAKEQHPDMSVTKVVVHKETE 1417
            |:||...:|||:|.|:.:.::|:
  Fly  1676 IQEATAMNPDMTVEKIEIQQQTQ 1698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epb41l3	XP_006523675.1	B41	120..309	CDD:214604	110/189 (58%)
		FERM_C_4_1_family	304..397	CDD:270005	81/92 (88%)
		FA	406..447	CDD:370090	16/40 (40%)
		SAB	755..802	CDD:367916	8/49 (16%)
		4_1_CTD	1312..1417	CDD:368659	45/111 (41%)
cora	NP_523791.2	B41	34..224	CDD:214604	110/189 (58%)
		FERM_N	36..98	CDD:286467	27/61 (44%)
		FERM_M	116..224	CDD:278785	73/107 (68%)
		FERM_C_4_1_family	219..312	CDD:270005	81/92 (88%)
		FA	323..363	CDD:285894	16/41 (39%)
		PQQ_2	829..>972	CDD:290097	34/174 (20%)
		4_1_CTD	1612..1698	CDD:283537	38/88 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841783
Domainoid	1	1.000	168	1.000	Domainoid score	I3813
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1278
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm43697
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4459
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780