DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epb41l2 and cora

DIOPT Version :9

Sequence 1:	XP_006512569.1	Gene:	Epb41l2 / 13822	MGIID:	103009	Length:	1062	Species:	Mus musculus
Sequence 2:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster

Alignment Length:	801	Identity:	289/801 - (36%)
Similarity:	391/801 - (48%)	Gaps:	200/801 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse   209 KTVLAKVTLLDGTEYSCDLEKRAKGQVLFDRVCEHLNLLEKDYFGLLFQDHPEQKNWLDPAKEIK 273
            |..||:||||||:.....::::|.|:.:.:.:|..|||:|||||||.::...:.:.|||..|.:.
  Fly    30 KPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVS 94

Mouse   274 RQLKNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEH 338
            :..:...|..||.||||||:||||.||||||.||||:|.||..|||||:||||||||||.:|:|.
  Fly    95 KFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQSEM 159

Mouse   339 GDYDPEEYDS-IDLGDFQFAPAHTKELEEKVSELHKTHRGLSPAQADSQFLENAKRLSMYGVDLH 402
            ||||.||..: ..|.||:.||..|.|||:||.:|||||:|.|||:|:..:|||||:|:|||||||
  Fly   160 GDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGVDLH 224

Mouse   403 HAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPAELEQFESTIGFK 467
            .|||||||||.|||||:|||:|:|:||||||||||||||||||.:||||:||.|.||:|||||||
  Fly   225 PAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTIGFK 289

Mouse   468 LPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKTK-FLTLGSKFRYSGRTQAQTREASTLIDRPAPQ 531
            |.||||||:|||.|||||||:||::||...|:| |...||.:||.|||||::  .:|.:||..|:
  Fly   290 LANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRYKGRTQAES--TNTPVDRTPPK 352

Mouse   532 FER--ASSKRVSRSLDGAPIGVVDQSPPGEGSVPGPGVISYTTIQDGRRDSKSPTKATPLPAEGK 594
            |.|  :.::..|||:|...:.                           ...|...|::.|...|.
  Fly   353 FNRTLSGARLTSRSMDALALA---------------------------EKEKVARKSSTLDHRGD 390

Mouse   595 KNTLRVDGDNIYVRHS-----NLMLEDLDKAQEAILKHQASISELKRNFMASTPEPRPSEWEKRR 654
            :|   .|||    .||     |...:|.||        :|.:.|.|:.   ...|....|.|||
  Fly   391 RN---ADGD----AHSRSPIKNKKEKDADK--------EAKLREKKQK---EKEEKERKEREKR- 436

Mouse   655 VTPLPFQPQASLEEEITSILFSGQGFSLSVKASFPSATTWTAEGPVVNANAPREPLSSSP----- 714
                      .|||:           ..:.||:..:.....|.|..||.|......:.|.
  Fly   437 ----------ELEEK-----------KKAEKAAKAALAAGAAAGAAVNGNDELNDSNKSDKSSGR 480

Mouse   715 -----FSHSPETR--PPTSEGPCTGPRDAVKSSHETLNVVEEKKRAEVGKDESVIT-------EE 765
                 ||...:::  .|:.:|.....:|               |..|||:...|:|       ::
  Fly   481 RGVGIFSSGRKSKSGSPSKDGKDKSGKD---------------KDKEVGRLGLVVTSGLGDNQQD 530

Mouse   766 MN----GKEMSPGHG---PGETRKVEPVAHKDSTSLSSESSSSSSESEEDVGEYQPHHRVTEGTI 823
            .|    .:..:...|   ||.||:.|.....|..:..:..|            |.|      |..
  Fly   531 QNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKS------------YTP------GGF 577

Mouse   824 REEQEECDEELEEEPGQGAKVVEREAAVPDAVPDRQAGA----SVLPVETEAQEHVVAQKLPGEK 884
            |.:|:                       |::   |::||    .:.|...:.:..:.....||.:
  Fly   578 RYDQD-----------------------PNS---RKSGADGQEQLSPTSQQKKIGLAFNYAPGNE 616

Mouse   885 GAHGGTAE-----------QD--------PREEAE--EDPHRVNGEVPHLDLDGLPEIICCSEPP 928
            .|...|||           ||        |:..|:  :||  :........|.|          .
  Fly   617 NALKETAEKLKAGQLSPRTQDKLNRGQLSPKSRAKLLQDP--LLSPTTRAKLQG----------S 669

Mouse   929 VVKTEMVTISDASQRTEISTK 949
            .|....|.:||:.:|:...||
  Fly   670 AVDAAAVPLSDSQKRSYSPTK 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epb41l2	XP_006512569.1	PTZ00121	<4..209	CDD:173412	289/801 (36%)
		B41	213..402	CDD:214604	105/189 (56%)
		FERM_C_4_1_family	397..490	CDD:270005	76/92 (83%)
		FA	500..543	CDD:400882	18/45 (40%)
		SAB	613..653	CDD:398195	9/39 (23%)
		PHA03247	<642..745	CDD:223021	21/114 (18%)
		4_1_CTD	950..1052	CDD:399118	289/801 (36%)
cora	NP_523791.2	B41	34..224	CDD:214604	105/189 (56%)
		FERM_N	36..98	CDD:286467	23/61 (38%)
		FERM_M	116..224	CDD:278785	71/107 (66%)
		FERM_C_4_1_family	219..312	CDD:270005	76/92 (83%)
		FA	323..363	CDD:285894	16/41 (39%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841779
Domainoid	1	1.000	168	1.000	Domainoid score	I3813
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1278
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm43697
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750