Protein Alignment Epb41l1 and cora

DIOPT Version :9

• Sequence 1: XP_006498771.1
• Gene: Epb41l1 / 13821
• MGIID: 103010
• Length: 1602
• Species: Mus musculus
• Sequence 2: NP_523791.2
• Gene: cora / 37205
• FlyBaseID: FBgn0010434
• Length: 1698
• Species: Drosophila melanogaster
• Alignment Length: 1902
• Identity: 512/1902 - (26%)
• Similarity: 740/1902 - (38%)
• Gaps: 615/1902 - (32%)

Mouse    87 SERTTPSKAQKSPQKIAKKFKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFG 151
            :|..||:|: |.....:...|.|:.||||||.|..:..:::...|:.:.:.:|..|||:||||||
  Fly    11 AEPETPTKS-KPKSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFG 74

Mouse   152 LTYCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGR 216
            |||......:.|||..|.:.|..|:..|...|.||||||:|:||.||||||:||||:|.||:.||
  Fly    75 LTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGR 139

Mouse   217 LPCSFVTHALLGSYAVQAELGDYDAEE-HVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 280
            |||:||||||||||.||:|:||||||| ....|:.:.:.|||||.|||:::|:||||::|.:|.|
  Fly   140 LPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAE 204

Mouse   281 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSN 345
            ||:|:|||||||:|||||||.||||||:||||||||:|||:|||:||||||||||||||||||.:
  Fly   205 AELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHH 269

Mouse   346 FYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG--FLVMGSKFRYS 408
            |||||||||:||:||||||||.|||:||:|||.|:||||||||::|||..|.  |.|.||.:||.
  Fly   270 FYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRYK 334

Mouse   409 GRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDG---AEFSRPASVSENHDAGPDGDKRED- 469
            |||||::  .:..:||..|.|.|:.|.....|||:|.   ||..:.|..|...|  ..||:..|
  Fly   335 GRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLD--HRGDRNADG 395

Mouse   470 DAESGGRRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPN 534
            ||.|            |:|.|.|            |::..||        :|.:.|.|:..||..
  Fly   396 DAHS------------RSPIKNK------------KEKDADK--------EAKLREKKQKEKEEK 428

Mouse   535 SKLIHRDRDWDRERRLPSSPASPSPKGTPEKASEAQRIHDTSQQDLVPGTAAGLEVFTQKSLAAS 599
            .:.....|:.:.:::             .|||::|.         |..|.|||..|.....|..|
  Fly   429 ERKEREKRELEEKKK-------------AEKAAKAA---------LAAGAAAGAAVNGNDELNDS 471

Mouse   600 PEGSEHWVLIERVYTRPEDLGLLTVPATQREESGSSLTEILADGRLSKVDILVDKFKVEVATEET 664
            .:..                          :.||.....|.:.||.||........|.:...::.
  Fly   472 NKSD--------------------------KSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKD 510

Mouse   665 VRAQRTSTQQQGKMIASPEGSETMREEDACLRGGPRDATRAAGYTSTDKLKLRNTRVSNGQTESH 729
            ....|.     |.::.|..|.   .::|..|....|:|.:..|.|:....:         |.|..
  Fly   511 KEVGRL-----GLVVTSGLGD---NQQDQNLDEAARNAAKNRGSTTPGVTR---------QYEYA 558

Mouse   730 VELNKGLERPQTWGRLTAAGVGPVQGEVLSPASDKGGLQSFLLDPAQTEARADSSDETDTSFAER 794
            |: |.|...|      |.....|            ||.: :..||...::.||..::...:..::
  Fly   559 VD-NDGNTSP------TRKSYTP------------GGFR-YDQDPNSRKSGADGQEQLSPTSQQK 603

Mouse   795 SFCL--NYGK------KDSEDSLLAPSLGDREEHLDAPPGDGTWLELAGAHTENWEPKS-----S 846
            ...|  ||..      |::.:.|.|..|..|.:.              ..:.....|||     .
  Fly   604 KIGLAFNYAPGNENALKETAEKLKAGQLSPRTQD--------------KLNRGQLSPKSRAKLLQ 654

Mouse   847 DP------RASAPGSSQNKDEAHMASSAEEAWSPRDRGRPDDLQGSAVCQTLEEGWENTQGLEG- 904
            ||      ||...||:.:.....::.|.:.::||                        |:|.:|
  Fly   655 DPLLSPTTRAKLQGSAVDAAAVPLSDSQKRSYSP------------------------TKGPQGY 695

Mouse   905 ---------ELAYPVADVAEDE---------APTSID----WMGKTEKKSP--PARWKKNPPGGG 945
                     .::.|.||..|.:         .|:..|    ..|....|.|  |.:..|..||..
  Fly   696 SSGAPGSYKPISDPTADFLESQRYNKEPGYVGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPGAA 760

Mouse   946 GGGGGGGGGGGGGGGGGGGRVHLDAQACALLRTIPPCVRKPVRPDQASFLPKEKGAV--STHAVE 1008
            .....|..|..........|   ..:...:.....|..::         :..|.|::  ||..::
  Fly   761 AAAAAGAAGAAAAAAKPKKR---RVKIMVITSKFDPSTKR---------IDAENGSIEHSTGILD 813

Mouse  1009 PET-----------EDREAVTPLPASSGHTEVLAAT---------SLSPV-PPRSGESSESRGFI 1052
            |.|           ..:..:..|...:|..||....         .:|.| .|::|...::.|.|
  Fly   814 PATGLIDTKYGVIDPKKGTLEALNTKTGKKEVFQGDVDGKTGNLHLVSGVADPKTGRLDDTLGQI 878

Mouse  1053 RDQSPVILKYIHLPEESPVHK--------DP---------------------------------- 1075
                 |.:    .|:::||.:        ||
  Fly   879 -----VCI----TPQDNPVVELTVITSRIDPATGKIDTVNGDVERSLGVLNLDTGLLDTKYGEIN 934

Mouse  1076 --QGERKA--PP----VASKKPRVVPEGTEGPALLGLVLPSGKLETSLQDRDQG-----GSQED- 1126
              .||.||  |.    |.||..:|.| ||....:||:|.|    :|:..|.:||     |.|.|
  Fly   935 TRTGELKAIDPKSGKIVVSKNVKVDP-GTGQITILGIVDP----KTNKIDPNQGRLIEVGQQIDP 994

Mouse  1127 -VSKTSVANKI-----------RIFETHG------AEPCRASQGEVRTLPH-----EPPS----- 1163
             |..||:|.|.           ...||.|      |.......|::..:.|     :|.|
  Fly   995 IVEVTSLAGKFDSKRNIIDPKTAQVETSGGQFDPKAGKIDTKYGQIDLVKHTITFNDPKSGKTVT 1059

Mouse  1164 -----EASPGQ--------------------------VEERSKP------------RDLGFV--- 1182
                 |.:.||                          |::|..|            :|...|
  Fly  1060 RDIKIEPTTGQIVLKNQVNPKNNKPDKDYARIISLRIVQQRVDPATKAPITEVSASKDKDIVVDP 1124

Mouse  1183 ---QLQPPGDLASP-----KVTCSSVMP---LATQHYGEATPTTSHQERCT--DPEL--VSPDSG 1232
               |:..|.....|     :...|||.|   .....||...|.|:..::.|  ||..  :.|.||
  Fly  1125 KSNQIWVPTGATDPATKEQQYISSSVDPKTGYVITIYGYLDPKTNEIKKQTKLDPNTIKIEPTSG 1189

Mouse  1233 CETT----LEEATG------SKAGDAGGEDKNSFGRLAPSTPGKGGRLRFASPPGLQRAGLREGS 1287
            ...|    :::|||      ::.....||......|:.|.|    |::      .:.|..|...:
  Fly  1190 KIYTATGEVDQATGEPLYAATQVDPESGEVYTKLARVDPKT----GKI------VIVRILLISKT 1244

Mouse  1288 EEKVKPPR--PRAPESD-----------------------TGDEDQDQERDAVFLKDNHLAIERK 1327
            :|:.:|..  |...|.|                       ||:..|....|..|..
  Fly  1245 DERGRPEEIDPSTCEIDPVSGRVLKFFNKTVYVYNMIDPVTGEIVQVDPNDPRFAG--------- 1300

Mouse  1328 CSSITVSSTSSLEAEVDFTVIGDYHGGAFEDFSRSLPELD------------------------- 1367
             :..||:.|.:|..|:| .|.|... ..:.|...:..::|
  Fly  1301 -ARTTVTHTMTLTGEID-PVTGRIK-SEYGDIDPNTGDIDPATAVTDPVTGKLILNYAQIDPSHF 1362

Mouse  1368 ----RDKSDSET---------EGL------VFARDLKGPSSQED--------------------E 1393
                :.::.:||         :|:      ...||.:| ||.:|                    :
  Fly  1363 GKQAQVQTTTETVPITRQQFFDGVKHISKGALRRDSEG-SSDDDMTAQYGADQVNEILIGSPAGQ 1426

Mouse  1394 SGGLEDSPDRGACSTPEMPQFESVKAETMTVSSLA------IRKKIEPEAMLQSRVSAADSTQVD 1452
            :||....|    .|||.:.:..:.:..|..:..:.      :|.....|....::...||:|..|
  Fly  1427 AGGKLGKP----VSTPTVVKTTTKQVLTKNIDGVTHNVEEEVRNLGTGEVTYSTQEHKADATPTD 1487

Mouse  1453 -GGTPMVKDFMTTPPCITTE--------------TISTTMEN----------------------- 1479
             .|..:....:||....|.|              |::||..:
  Fly  1488 LSGAYVTATAVTTRTATTHEDLGKNAKTEQLEEKTVATTRTHDPNKQQQRVVTQEVKTTATVTSG 1552

Mouse  1480 ---------SLKSGKGAAAMIPGPQTVATEIRS---LSP-----------------IIGKDVLTS 1515
                     |..|...:...|.||...|:.:|:   .||                 ::|:|  |.
  Fly  1553 DQYQRRDSVSSTSSGDSGTPIDGPYDGASVVRTDNQKSPLFTTSATTGPHVESTRVVLGED--TP 1615

Mouse  1516 TYGATAETLSTSTTTHVTKTV--------KGGFSETRIEKRIIITGDED-VDQDQALALAIKEAK 1571
            .:....|.:||.|.:..|:||        :.|..|||:|::|.|..|.| :|.|:|||.||:||.
  Fly  1616 GFSGHGEIISTQTVSSKTRTVETITYKTERDGIVETRVEQKITIQSDGDPIDHDKALAEAIQEAT 1680

Mouse  1572 LQHPDMLVTKAVVYRET 1588
            ..:|||.|.|..:.::|
  Fly  1681 AMNPDMTVEKIEIQQQT 1697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epb41l1	XP_006498771.1	B41	111..300	CDD:214604	108/189 (57%)
		FERM_C_4_1_family	295..388	CDD:270005	78/92 (85%)
		FA	397..438	CDD:370090	17/42 (40%)
		SAB	506..>536	CDD:367916	7/29 (24%)
		4_1_CTD	1465..1589	CDD:368659	48/199 (24%)
cora	NP_523791.2	B41	34..224	CDD:214604	108/189 (57%)
		FERM_N	36..98	CDD:286467	25/61 (41%)
		FERM_M	116..224	CDD:278785	72/107 (67%)
		FERM_C_4_1_family	219..312	CDD:270005	78/92 (85%)
		FA	323..363	CDD:285894	17/41 (41%)
		PQQ_2	829..>972	CDD:290097	30/152 (20%)
		4_1_CTD	1612..1698	CDD:283537	33/88 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841781
Domainoid	1	1.000	168	1.000	Domainoid score	I3813
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1278
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4459
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.680