Protein Alignment HGSNAT and Hgsnat

DIOPT Version :10

• Sequence 1: XP_005273466.1
• Gene: HGSNAT / 138050
• HGNCID: 26527
• Length: 672
• Species: Homo sapiens
• Sequence 2: NP_572198.1
• Gene: Hgsnat / 31423
• FlyBaseID: FBgn0029737
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 654
• Identity: 228/654 - (34%)
• Similarity: 331/654 - (50%)
• Gaps: 112/654 - (17%)

Human    43 KKRHAE---LKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKPSAAAASVS 104
            |.||.:   |.:|:..|.:.:|.. :...:|..|:.||.|        |.:.....|:|..|:|.
  Fly    11 KWRHLDMRALSVDEFYLYLRSEFS-SQTHLYSLSDECYTC--------PYTKVKALPAADVAAVV 66

Human   105 TQH---GSILQLNDTLEE-----------KEVCRLEYR-FGEFGNYSLLVKNIHNGVSEIACDLA 154
            .:.   .|...||..:.:           ..:|.|... ..|||.|:|.::  .||    .|..|
  Fly    67 VEPLRLSSAYSLNFKIFDLDQGHYAYDNVSSLCWLRRSDLQEFGVYNLTLQ--ANG----TCAFA 125

Human   155 VNEDPVDSNLPVSIAFLIGLAVIIVISFLRLLLSLDDFNNWISKAISSRETDRLINSELGSPSRT 219
            |::..|    |::.||   :||.::::.|.:.|.|      :|.|......|.       :.:..
  Fly   126 VDKPGV----PINYAF---IAVFVLVAALLIALKL------VSCAWRYYRYDE-------ATAAA 170

Human   220 DPLDGDVQPATWRLSALPPRLRSVDTFRGIALILMVFVNYGGGKYWYFKHASWNGLTVADLVFPW 284
            |.:......||.|     .||||:||||||:::||:|||.|||.|.:.:||:||||.:||:|||.
  Fly   171 DSIGEAATKATQR-----KRLRSLDTFRGISIVLMIFVNSGGGGYAWIEHAAWNGLHLADVVFPS 230

Human   285 FVFIMGSSIFLSMTSILQRGCSKFRLLGKIAWRSFLLICIGIIIVNPNYCLGPLSWDKVRIPGVL 349
            |::|||..|.||:.|.|.||.||.|:..:|.|||..|..||:.:   |...|| :.:::||.|||
  Fly   231 FLWIMGVCIPLSVKSQLSRGSSKARICLRILWRSIKLFVIGLCL---NSMSGP-NLEQLRIMGVL 291

Human   350 QRLGVTYFVVAVLELLFAKPVPEHCASERSC-LSLRDITSSWPQWLLILVLEGLWLGLTFLLPVP 413
            ||.||.|.|||:|..|..:..|  .:.:||. .::.|:.....:..::|.|...:|||||.|.||
  Fly   292 QRFGVAYLVVAILHTLCCRREP--ISPQRSWQRAVHDVCLFSGELAVLLALVATYLGLTFGLRVP 354

Human   414 GCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGDDHLYQHPSSAVLYHTEVAYDPEGILGTIN 478
            |||.|||||||..|:..:|.|.||||||.|..:||:.|:||||::..:|.: .|:|||||.|.|.
  Fly   355 GCPRGYLGPGGKHDYNAHPKCIGGAAGYADLQVLGNAHIYQHPTAKYVYDS-TAFDPEGIFGCIL 418

Human   479 SIVMAFLGVQCCPDWVTKQACLTEPLSPLWRILFGPCLEVRATEPAQAGKILLY---YKARTKDI 540
            |:|...||                                     |.||..||.   :::|.:
  Fly   419 SVVQVLLG-------------------------------------AFAGVTLLVHPNFQSRIR-- 444

Human   541 LIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWSLSYVTTLSSFAFFILLVLYPVVDVKGL-- 603
              |:|....:||||..||...|...|.||:||||||||:|....|.|..||.::|..:||:..
  Fly   445 --RWTLLAILLGLIGGALCGFSREGGAIPMNKNLWSLSFVCVTVSLALLILSLMYYFIDVRETWS 507

Human   604 WTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRKKI 668
            |:|.||...|||:|::||||.|.....|:.|::.:..:|...|.:....|.:||.||..|..::.
  Fly   508 WSGYPFTECGMNAIVMYVGHSVLHKMLPWHWRIGEMNTHFMLLLEATWNTLVWVGIALYLDAQEF 572

Human   669 FWKI 672
            ::.:
  Fly   573 YYSV 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HGSNAT	XP_005273466.1	COG4299	237..672	CDD:443440	180/440 (41%)
Hgsnat	NP_572198.1	COG4299	182..568	CDD:443440	180/438 (41%)