Protein Alignment En1 and Dr

DIOPT Version :10

• Sequence 1: NP_034263.2
• Gene: En1 / 13798
• MGIID: 95389
• Length: 401
• Species: Mus musculus
• Sequence 2: NP_477324.1
• Gene: Dr / 45285
• FlyBaseID: FBgn0000492
• Length: 515
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 119/535 - (22%)
• Similarity: 167/535 - (31%)
• Gaps: 235/535 - (43%)

Mouse     8 PKSQRDSGLGAV--------AAAAPSG-----LSLSLSPGASGSSGSDGDSVPVSPQPAPPSPP- 58
            |.|...:||...        ::..|:|     .|.|.|...|||:.|.|:....:.....||.|
  Fly     6 PASMTVTGLRQTMTSPTVPPSSNTPAGNLIITSSSSNSGSNSGSNMSSGNMTSSNLTNLSPSHPA 70

Mouse    59 -----AAPCLPP---LAHHPHL-----------------------PPHPP--------------- 77
                 |:|..|.   |||..||                       ..|||
  Fly    71 GLNALASPTSPSALLLAHQQHLLQQHQQHQQQQQQQQQAAALQLAAVHPPAHHLHKTTSRLSNFS 135

Mouse    78 ---------PPPPP-------------------------PPPPPQHLAA--PAHQPQPAAQLHRT 106
                     |..||                         |||||...||  ||:...|||..|..
  Fly   136 VASLLADTRPRTPPNQAADGPQNLTSSAATSPISQASSTPPPPPASAAAQVPANTFHPAAVAHHA 200

Mouse   107 TNFFIDNILRPDFGCKKEQPLPQLLVASAAAGGGA---AAGGGSRVERDRGQTGAGRDPVHSLGT 168
                  ::|:               .|.|||...|   |.....|.::.:....|...|..:..|
  Fly   201 ------HLLQ---------------AAHAAAAAHAQHQAMAAQLRQQQQQADARANSPPASTSST 244

Mouse   169 RAS---GAA-----------------------------------------------SLLCAPDAN 183
            .:|   |:|                                               |::...|.|
  Fly   245 PSSTPLGSALGSQGNVASTPAKNERHSPLGSHTDSELEYDEEMLQDHEADHDEEEDSIVDIEDMN 309

Mouse   184 C----------------------GPPDGS-QPATAVSAGASKAGNPAAAAAAAAAAAAAAVAAAA 225
            .                      |||.|| ..:|.:|..|..:|:........:|.||||||..
  Fly   310 ADDSPRSTPDGLDGSGKSLESPHGPPPGSHMQSTILSPAALASGHVPIRPTPFSALAAAAVAWT- 373

Mouse   226 AAASKPSDSGGGSGGNAGSPGAQGAKFPEHNPAILLMGSANGGPVVKTDSQQPLVWPAWVYCTRY 290
                       |.||....||.:  :.|...|..:..|:..||     |:.:|
  Fly   374 -----------GMGGGVPWPGTR--QMPPFGPPGMFPGAGFGG-----DANEP------------ 408

Mouse   291 SDRPSSGPRTR-KLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLNES 354
                   ||.: .|:|   .|.:::|||.||.:||..|:.:|:..:|::...|...:..|.|.|:
  Fly   409 -------PRIKCNLRK---HKPNRKPRTPFTTQQLLSLEKKFREKQYLSIAERAEFSSSLRLTET 463

Mouse   355 QIKIWFQNKRAKIKK 369
            |:||||||:|||.|:
  Fly   464 QVKIWFQNRRAKAKR 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
En1	NP_034263.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..102		42/189 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..167		5/31 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..253		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..315		5/22 (23%)
		Homeodomain	314..369	CDD:459649	24/54 (44%)
		Engrail_1_C_sig	370..400	CDD:431338	119/535 (22%)
Dr	NP_477324.1	Homeodomain	422..478	CDD:459649	24/55 (44%)