Protein Alignment PXDNL and CG4009

DIOPT Version :10

• Sequence 1: NP_653252.4
• Gene: PXDNL / 137902
• HGNCID: 26359
• Length: 1463
• Species: Homo sapiens
• Sequence 2: NP_650588.2
• Gene: CG4009 / 42054
• FlyBaseID: FBgn0038469
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 699
• Identity: 206/699 - (29%)
• Similarity: 297/699 - (42%)
• Gaps: 167/699 - (23%)

Human   672 IRERVKQGLTVDLEGKEFR--------YNDLVSPRSLSLIANLSGCTARRPL------PNCSNRC 722
            ||..|..| ::|...|||.        :|....|.:           :::||      .||.|..
  Fly    38 IRPGVSDG-SLDALIKEFMPKYNGNNVHNSWAEPSA-----------SQQPLRCGVPPRNCLNDT 90

Human   723 FHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAP--RGLGLPVGSRQPLPPPRLVAT 785
            .:..||..||:||||..|.:|.|::.:.|||.|  |...:||  |.:.|.:...|
  Fly    91 RNLHYRTLDGSCNNLLYPEFGIAVSRYRRLLPP--RQVEQAPNARLISLSLYGEQ---------- 143

Human   786 VWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRP---CSSVCTNDPPCFPMNT 847
                   ...|...|...|.||.|:.||:..    |||    .|.|   |:.  ...|.|.|:|.
  Fly   144 -------TRNDRFRTMAAMQWGQFVAHDISQ----LST----QGAPQDCCAE--PRHPRCLPINL 191

Human   848 RHADPRGTHA--PCMLFARS-------SPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSS 903
            ....|...|.  .|:.||||       .|.....:|          |::...|||:|.|::||::
  Fly   192 PRGGPIAYHTGKTCLHFARSVSDADAICPKVEEPQP----------EKLTVATAYLDLSSIYGNN 246

Human   904 ERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALA 968
            ..:::.:|  ....|||||.:   .:|:..||.|.....||.   .:|.|::..|.|......:|
  Fly   247 PSQNRKVR--LFKGGLLKTSY---TNGQHWLPVSQNENGECG---AKSECYIVPDIRNRFSPTIA 303

Human   969 AMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRG- 1032
            .:.||..|||||:|..|:.:||......::||||||..|:.|.|||..|||..:|...| .|.|
  Fly   304 LLQTLLVREHNRLAENLALINPDHSDERIFQEARKINIAQFQKITYYDWLPLFVGRTYT-YLNGL 367

Human  1033 ---------YRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSP 1088
                     ...|:..||......|:.||||:.||                   .:|...:|.:|
  Fly   368 IYPVEPTEYVNDYDETVNPAAYAEFSAAAFRYAHT-------------------QIPGWFSLVAP 413

Human  1089 SR--------------------IIKEGGIDPVLRGLFGVAAKWRAPS----------YLLSPELT 1123
            :|                    :......|.:||||   |.:....|          |....|..
  Fly   414 NRRSNRTMRLSDFLDRTETIRLLDTSDNFDALLRGL---ATQLHKRSDGNIDREIKHYFNRKEFE 475

Human  1124 QRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLY 1188
            :      |.:  |..:..|||.||.|:..|.|.|.||.|....::.|..:||...:| ..||:||
  Fly   476 E------YGS--DLKSIDIQRARDFGLASYNDVREFCGLRRAVDWADFAHEIPGEKI-SLLRRLY 531

Human  1189 GSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWY--ENPGVFTPAQLTQLKQA 1251
            .:|.|::|.....:|..:|....||||:|:...||...|.||||::  ||.|.|:.|||.::::.
  Fly   532 ATPDDVELGVGGTLEYHVPDALFGPTLLCVIGKQFLNTRRGDRFFFERENEGGFSRAQLAEIRKV 596

Human  1252 SLSRVLCDNGDSIQQVQADVFVKAEYPQDY---LNCSEIPKVDLRVWQD 1297
            |||.:.|.|.:.:..:|.:|||   :|..:   |||:.||::||..|||
  Fly   597 SLSSLFCSNANYLHLIQPNVFV---FPNSHNLLLNCNFIPQIDLSKWQD 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PXDNL	NP_653252.4	LRR	<36..>194	CDD:443914
		LRR 1	51..72
		leucine-rich repeat	52..85	CDD:275378
		LRR 2	75..96
		leucine-rich repeat	86..123	CDD:275378
		LRR 3	99..120
		LRR_8	123..182	CDD:404697
		LRR 4	123..144
		leucine-rich repeat	124..147	CDD:275378
		LRR 5	147..168
		leucine-rich repeat	148..171	CDD:275378
		leucine-rich repeat	172..184	CDD:275378
		LRRCT	180..232	CDD:214507
		Ig_3	234..309	CDD:464046
		Ig_3	329..402	CDD:464046
		Ig	432..505	CDD:472250
		Ig strand B	436..440	CDD:409353
		Ig strand C	449..453	CDD:409353
		Ig strand E	471..475	CDD:409353
		Ig strand F	485..490	CDD:409353
		Ig strand G	499..502	CDD:409353
		Ig	528..596	CDD:472250
		Ig strand B	528..532	CDD:409353
		Ig strand C	541..545	CDD:409353
		Ig strand E	563..567	CDD:409353
		Ig strand F	577..582	CDD:409353
		Ig strand G	591..594	CDD:409353
		peroxidasin_like	851..1286	CDD:188658	145/488 (30%)
		VWC	1400..1450	CDD:214564
CG4009	NP_650588.2	An_peroxidase	95..617	CDD:460804	177/600 (30%)