DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PXDNL and Lar

DIOPT Version :9

Sequence 1:NP_653252.4 Gene:PXDNL / 137902 HGNCID:26359 Length:1463 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1100 Identity:219/1100 - (19%)
Similarity:370/1100 - (33%) Gaps:330/1100 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   330 PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDG--SRHVATS--SGLYLQNI-- 388
            |..:.:||:..|.:|...:..|.|.|.|.|.|.| |.||.::.|  ||:....  .|:.:..|  
  Fly    36 PEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVW-RKNGKKVSGTQSRYTVLEQPGGISILRIEP 99

Human   389 --TQRDHGRFTCHANNSHG-TVQAAANIIV----QAP---PQFTVTPKDQVVLEEHAVEWLCEAD 443
              ..||...:.|.|.|..| .|.|.|.:.:    :.|   |..|..|..:|:...|.|...|:|.
  Fly   100 VRAGRDDAPYECVAENGVGDAVSADATLTI
YEGDKTPAGFPVITQGPGTRVIEVGHTVLMTCKAI 164

Human   444 GNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVK-KVSVQLTVKP 507
            |||.|.|.|.|...::.:......|..|.|:|:.:.:.|||:|||.|.:|:|.: ..:..|.||.
  Fly   165 GNPTPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKATNLYVKV 229

Human   508 KALAVFTQLPQDTSVEV--GKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDA 570
            :.:......|.:|..||  |.|:|:||.|.|.|.|.:.|.|....:|...:..:   |...:...
  Fly   230 RRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPI---GRNVLQLI 291

Human   571 GFPDQGRYECVARNSFG--------------LAVTNMFL---TVTAI------------------ 600
            ...:...|.|:|.::.|              .|.|::.:   |.|::                  
  Fly   292 NIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQISEVTATSVRLEWSYKGPEDLQYYVIQ 356

Human   601 -QGRQAGDDFVESSILDAVQRVDSAINSTRRHLF------------SQKPHT------------- 639
             :.:.|...|.|.|.:..:..|..|::....:.|            ...|.|             
  Fly   357 YKPKNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGGTKM 421

Human   640 -------------SSDLLAQFHYPRDP-------------------------LI--VEMARAGEI 664
                         ||.::..:..|..|                         ::  .|:....|:
  Fly   422 ESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNSQMVDNSELTTVSEL 486

Human   665 FEHTLQLIR---------------ERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTA--- 711
            ..|.:..:|               .:||....|..:...||..|:             |.||   
  Fly   487 TPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDI-------------GETAVTL 538

Human   712 --RRPLPNCSNRCFHAKY-------RAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGI------ 761
              .:|..:..|...:..|       :||....:|.:           |..|...|.|.:      
  Fly   539 QWTKPTHSSENIVHYELYWNDTYANQAHHKRISNSE-----------AYTLDGLYPDTLYYIWLA 592

Human   762 -RAPRGLG-----LPVGSRQPLPPPRLVATVWARAAAVT-------PDHSYTRMLMHWGWFLE-- 811
             |:.||.|     :||.::|...|||.:..:...:..::       .:.|..|::.:..:|:|  
  Fly   593 ARSQRGEGATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVG 657

Human   812 -HDLDHTVPALSTA--------RFSDGR--PCSSVCTND-PPCFPMNTR-----HADPRGTHAPC 859
             .|.:.|...|:..        |:::.:  ..:.....| |...|:..|     ..||:...|..
  Fly   658 REDDEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQEDVPGDPQDVKATP 722

Human   860 MLFARSSPACASGRPSATVD--------SVYAREQINQQTAYIDGS-----------NVYGSSER 905
            :   .|:....|.:|....|        .::|:|..::...:::..           ||.|....
  Fly   723 L---NSTSIHVSWKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPD 784

Human   906 ESQALRDPSVPRG---------LLKTGFPWPPSGKPLLP-----FSTGPPTECARQEQESPCFLA 956
            ...:::..::.|.         ::||     |.|.|:.|     .....|......|.|.|....
  Fly   785 TKYSIQVAALTRKGDGDRSAAIVVKT-----PGGVPVRPTVSLKIMEREPIVSIELEWERPAQTY 844

Human   957 GDHRA-------------NEHLALAAMHTLWFREHNR-MATELSALNPHWEGNTVYQEARKIV-- 1005
            |:.|.             .|.|:...|....|....| :..|......:..|  :.||..||.  
  Fly   845 GELRGYRLRWGVKDQALKEEMLSGPQMTKKRFDNLERGVEYEFRVAGSNHIG--IGQETVKIFQT 907

Human  1006 -----GAELQHITYSHWLPKVL---GDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINP 1062
                 |....:||.....|.||   .||.||..|.          |||..:.....:        
  Fly   908 PEGTPGGPPSNITIRFQTPDVLCVTWDPPTREHRN----------GIITRYDVQFHK-------- 954

Human  1063 ILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPEL---TQ 1124
               :::..||  ||.::...||:|:        .::.....:|.|.|..:..:...|.:|   |:
  Fly   955 ---KIDHGLG--SERNMTLRKAVFT--------NLEENTEYIFRVRAYTKQGAGPFSDKLIVETE 1006

Human  1125 RLFSAA---YSAAVDSAAT-------IIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNE 1174
            |....|   ..|...|..|       :..||:      .:.:::|..:|:|::.:|.|.:
  Fly  1007 RDMGRAPMSLQAEATSEQTAEIWWEPVTSRGK------LLGYKIFYTMTAVEDLDDWQTK 1060

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PXDNLNP_653252.4 LRR 1 51..72
leucine-rich repeat 52..85 CDD:275378
LRR_8 53..134 CDD:316378
LRR 2 75..96
leucine-rich repeat 86..123 CDD:275378
LRR 3 99..120
LRR_8 123..182 CDD:316378
LRR 4 123..144
leucine-rich repeat 124..147 CDD:275378
LRR 5 147..168
leucine-rich repeat 148..171 CDD:275378
leucine-rich repeat 172..184 CDD:275378
LRRCT 180..232 CDD:214507
Ig_3 234..309 CDD:316449
Ig_3 329..402 CDD:316449 24/79 (30%)
Ig 432..505 CDD:325142 25/73 (34%)
Ig 528..596 CDD:325142 17/84 (20%)
peroxidasin_like 851..1286 CDD:188658 75/393 (19%)
VWC 1400..1450 CDD:214564
LarNP_001260594.1 Ig 35..129 CDD:299845 29/93 (31%)
I-set 36..129 CDD:254352 29/93 (31%)
IG_like 146..227 CDD:214653 27/80 (34%)
Ig 159..228 CDD:299845 23/68 (34%)
I-set 234..318 CDD:254352 21/86 (24%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 17/70 (24%)
fn3 324..404 CDD:278470 11/79 (14%)
FN3 423..514 CDD:238020 8/90 (9%)
FN3 520..610 CDD:238020 22/113 (19%)
FN3 616..707 CDD:238020 14/90 (16%)
FN3 712..810 CDD:238020 13/100 (13%)
FN3 832..907 CDD:238020 16/76 (21%)
FN3 914..1005 CDD:238020 25/121 (21%)
FN3 1012..1101 CDD:238020 11/54 (20%)
fn3 1106..1198 CDD:278470
PTPc 1476..1731 CDD:214550
PTPc 1503..1731 CDD:238006
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2408
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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