DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PXDNL and CG10211

DIOPT Version :9

Sequence 1:	NP_653252.4	Gene:	PXDNL / 137902	HGNCID:	26359	Length:	1463	Species:	Homo sapiens
Sequence 2:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster

Alignment Length:	1486	Identity:	383/1486 - (25%)
Similarity:	593/1486 - (39%)	Gaps:	420/1486 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    28 CLCFKS-TVRCMHLMLDHIPQVPQQTTVLDLRFNRIREI--------------------PGSAFK 71
            |||..| |:|        ||:..:...:..|...|.|.:                    |.|.::
  Fly    14 CLCASSLTLR--------IPEDLENAAINALSSERARSLTPCGSSAEAEGSVAGDYDVCPPSKYR 70

Human    72 KLKNLNTLLLNNNHIRK-----------ISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLE 125
            :    .|...||...||           ::.:..:|:.               ..:|.||..:|.
  Fly    71 Q----PTAECNNVSHRKWGARGDIFQRLLAADYADGVS---------------QPRTSKGTHALP 116

Human   126 HLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPA-GSFSNLDSLKRLRLDSNALVCDCD-- 187
            ...:   .:|.||....|:|       .|.:..:.:|| |.....|.::..:|..:...|:.|
  Fly   117 DAEV---VIEQLQRHVEGEL-------RHAHITAMLPAWGQLLANDLVEVGQLPISGKCCERDSA 171

Human   188 LMWLGELLQGFAQHGHTQAAATC-EYPRRLHG---RAVASVTVEEFNCQSPRITFEPQDVEVPSG 248
            :....||     ||...:|...| ||.|...|   .|....|.::.|..|..|          .|
  Fly   172 VKDPSEL-----QHCFVRAGPDCKEYKRSAPGFDLEACQKHTRQQMNIASAYI----------DG 221

Human   249 NTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGE 313
            :.:|.:.|               |..|     :|..:..|.:.:.:.:       .|....:.|
  Fly   222 SGLYGSTR---------------HEFD-----QLRTYISGGVKVESCK-------YCQVAGATG- 258

Human   314 AKTQSAMLRYSSLPAKPSFVIQP--QDTEVLIGT----STTLECMATGHPHPLI---TWTRDNGL 369
            |..::.:.:::::..:.|. |.|  .:.:|.:..    :.|::.:......||:   ..|...||
  Fly   259 ALHRALLQQHNNIGERLSH-INPDWSEEDVFLEARRIITATIQHITYNEFLPLVLGQETTAKEGL 322

Human   370 ELDGSRHVATSS-----GLYLQNITQ--------------------------------------- 390
            .|...:|.:..|     |:|.:..|.
  Fly   323 RLTAEKHSSNYSSSVRGGIYNEFATAAMPAFWSMYPPEMLAKKMSAHELLSIAALQKSLVPSQTN 387

Human   391 --------------RDHG-------------RFT--CHANNSHGTVQAAANIIVQAPPQFTVTPK 426
                          ||||             ||.  ..||.|..|:...:||     |:..:|..
  Fly   388 AEGWSELALAVHRGRDHGVASYVHALDLCERRFADQSAANVSFDTLAQVSNI-----PEEYITNL 447

Human   427 DQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQL--PVEGQ---HTVLSSGTLRIDRAAQHDQGQY 486
            ..:....:.::.|               .|..|  ||.|.   .|:....:|:.::..|.|:..|
  Fly   448 RDIYQNANDIDLL---------------VGALLEEPVVGALFGPTISCLLSLQFEQLKQTDRFWY 497

Human   487 ECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQI 551
            |.:               :.|.:   || |.|..|:.......:.|   |..|         |..
  Fly   498 ENE---------------IPPSS---FT-LDQLKSIRQTTLSGLLC---GSHQ---------VST 531

Human   552 TESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLA-----------VTNMFL---TVTAIQG 602
            .:|..|.::|....:|.|          |.....|.|.           |.::.:   |..||
  Fly   532 AQSKAFILEDNYLNSILD----------CDQLPKFDLKPWQVNPEDEVHVEHVEVEPATKEAI-- 584

Human   603 RQAGDDFVESSI------LDAVQRVDSAINSTRRHLFSQKPH-TSSDL----LAQFHYPRDPLIV 656
            .:...:.:|:::      |:..:|.:..:..|:..:.::.|. |::..    ||..:.....||.
  Fly   585 AELSPELIEAAVERAKQELEERKRFEYEVWRTKGGISARSPDGTAASFSKANLAALNLANSSLIF 649

Human   657 EMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNC--- 718
            |:. :.||.: ||..|..|.:|  ..:.....|..|:|........|:.|.| .|::.|..|
  Fly   650 ELT-SNEIVK-TLNHITRRKRQ--IFNPNQNAFNRNELTDTLQTVDISGLLG-GAQKQLDTCPEP 709

Human   719 SNRC-FHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRL 782
            |.:| .::.:|...|.||||:.|.||.:||.|:|||...|.|||.|||..|:   :...||.||.
  Fly   710 SQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPRLTGV---TGTALPNPRT 771

Human   783 VATVWARAAAVTPDHS-----YTRMLMHWGWFLEHDLDHT---------VPALSTARFSDGRPCS 833
            ::|      .:.||.|     |:.|:|.:..|::|||..|         :|:.        |||:
  Fly   772 IST------TIHPDISNLHTRYSLMVMQFAQFVDHDLTLTPIHKGFHESIPSC--------RPCN 822

Human   834 SVCTNDPPC--FPMNTRHADPRGT-HAP----------CMLFARSSPACASGRPSATVDSVYARE 885
            |..|..|.|  ||:      |.|. :.|          |....||.|...|..|         |:
  Fly   823 SRQTVHPECNPFPV------PAGDFYYPEVNVTSGERFCFPSMRSLPGQQSLGP---------RD 872

Human   886 QINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPS-----GKPLLPFSTGPPTECA 945
            ||||.|.::|||.|||.:...|..||           ||....:     ||.|||.  ||..||
  Fly   873 QINQNTHFLDGSMVYGETTCLSNKLR-----------GFSGRMNSTQVRGKELLPL--GPHPEC- 923

Human   946 RQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQ 1010
             :.:...|||.||.||:|...|.|:||.:.|||||:...|..:||||.|..::..|||||.|::|
  Fly   924 -KSRNGLCFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQ 987

Human  1011 HITYSHWLPKVLGDP-----GTRML-RG-YRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLN 1068
            ||.::.:||::|...     |.::| :| |:.|||:.:..:.|.||.||||.||:|:.|.:.||
  Fly   988 HIVFNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRL- 1051

Human  1069 ATLGEISEGHLPFHKAL------FSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLF 1127
                  |..|.|....|      |....:::.|.||.:||||  ||.........::.|:|..||
  Fly  1052 ------SVQHQPVEPPLLLRDGFFRMDALLQPGIIDEILRGL--VATPMETLDQFITGEVTNHLF 1108

Human  1128 ---SAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYG 1189
               ...:| .:|..|..|||.||||||.|.::|..|||....|:.||..|| .:|:..:.:|:|.
  Fly  1109 EDRKIPFS-GIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREI-PTEVINRFQKIYA 1171

Human  1190 SPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYE--NPGV-FTPAQLTQLKQA 1251
            |..||||:|..|.|..:.|..|||||.|:...||::||..||||||  ||.| ||.|||.::::.
  Fly  1172 SVDDIDLFPGAMTERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKV 1236

Human  1252 SLSRVLCDNGDSIQQVQADVFVKAEYPQDYLN----CSEIPKVDLRVWQDCCADCR 1303
            :|::::|:|.:....:|...|   :.|.::||    |:.:|::||..|::....|:
  Fly  1237 TLAKIVCENLEITGDMQRAAF---DLPSNFLNPRVPCASMPQIDLNAWRENVQGCQ 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PXDNL	NP_653252.4	LRR 1	51..72		5/40 (13%)
		leucine-rich repeat	52..85	CDD:275378	8/52 (15%)
		LRR_8	53..134	CDD:316378	15/111 (14%)
		LRR 2	75..96		5/31 (16%)
		leucine-rich repeat	86..123	CDD:275378	6/47 (13%)
		LRR 3	99..120		1/20 (5%)
		LRR_8	123..182	CDD:316378	12/59 (20%)
		LRR 4	123..144		4/20 (20%)
		leucine-rich repeat	124..147	CDD:275378	6/22 (27%)
		LRR 5	147..168		4/21 (19%)
		leucine-rich repeat	148..171	CDD:275378	4/23 (17%)
		leucine-rich repeat	172..184	CDD:275378	1/11 (9%)
		LRRCT	180..232	CDD:214507	15/57 (26%)
		Ig_3	234..309	CDD:316449	9/74 (12%)
		Ig_3	329..402	CDD:316449	23/154 (15%)
		Ig	432..505	CDD:325142	12/77 (16%)
		Ig	528..596	CDD:325142	13/81 (16%)
		peroxidasin_like	851..1286	CDD:188658	175/473 (37%)
		VWC	1400..1450	CDD:214564
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139	96/566 (17%)
		An_peroxidase_like	209..524	CDD:265428	61/392 (16%)
		An_peroxidase	719..1245	CDD:281139	217/583 (37%)
		peroxinectin_like	871..1245	CDD:188655	159/399 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820