Protein Alignment PXDNL and Duox

DIOPT Version :10

• Sequence 1: NP_653252.4
• Gene: PXDNL / 137902
• HGNCID: 26359
• Length: 1463
• Species: Homo sapiens
• Sequence 2: NP_608715.2
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Alignment Length: 731
• Identity: 192/731 - (26%)
• Similarity: 315/731 - (43%)
• Gaps: 108/731 - (14%)

Human   719 SNRCFHAKY-----RAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLP 778
            |..|:...|     :.:||..|||..|.||:..:...|...|:|.||:.|..|..        .|
  Fly    56 SVHCYEKMYSQTEKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGAN--------RP 112

Human   779 PPRLVATVWARAA-AVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPC 842
            ..|.::.::.|.. .:....:.|.:|..:|..:.:::        ......|.|..........|
  Fly   113 STRRLSRLFMRGKDGLGSKFNRTALLAFFGQLVANEI--------VMASESGCPIEMHRIEIEKC 169

Human   843 FPMNTRHADPRG-THAPCMLFARSSPACASGR-PSATVDSVYAREQINQQTAYIDGSNVYGSSER 905
            ..|..|..  || .:.|   |.|::....:|: |:|      .||||||.||:||||.:|.:||.
  Fly   170 DEMYDREC--RGDKYIP---FHRAAYDRDTGQSPNA------PREQINQMTAWIDGSFIYSTSEA 223

Human   906 ESQALRDPSVPRGLLKTGFPWPPSGK-PL-----LPFSTGPPTECARQEQESPCFLAGDHRANEH 964
            ...|:|  |...|.|.|    ...|| |:     :|....|.....:.......||.||.|.|::
  Fly   224 WLNAMR--SFHNGTLLT----EKDGKLPVRNTMRVPLFNNPVPSVMKMLSPERLFLLGDPRTNQN 282

Human   965 LALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRM 1029
            .|:.:...|:.|.||.:|..:..::|.|....:||.||..|.|.||::....:||..||    ..
  Fly   283 PAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLG----TS 343

Human  1030 LRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPF-HKAL------FS 1087
            |..|.||..:::.||.:.|..||||||||:|.|.:||.:   |:.:....|. :.|:      :.
  Fly   344 LPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRD---GQCNFKETPMGYPAVRLCSTWWD 405

Human  1088 PSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPP 1152
            .|....:..::.||.||....::...|  :|..::..:||........|..|..|.||||:|:|.
  Fly   406 SSGFFADTSVEEVLMGLASQISEREDP--VLCSDVRDKLFGPMEFTRRDLGALNIMRGRDNGLPD 468

Human  1153 YVDFRVFCNLTSVKNFEDLQNEIKDS--EIRQKLRKLYGSP-GDIDLWPALMVEDLIPGTRVGPT 1214
            |...|....|...|.:.|:...:.::  |:...|::.|.:. .|:|::...|:|..   .:.|..
  Fly   469 YNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDVYVGGMLESY---GQPGEF 530

Human  1215 LMCLFVTQFQRLRDGDRFWYENP--GVFTPAQLTQLKQASLSRVLCDNGD-SIQQVQADVFV--- 1273
            ...:...|||||||.||||:||.  |:|||.::.:|::.:|..::.::.| ..:::|.|||:
  Fly   531 FTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTDVKEEEIQKDVFMWRT 595

Human  1274 KAEYPQ------------------DYLNCSEIPKVDLRVWQDCCAD-CRSRGQFRAVTQESQKK- 1318
            ....||                  ||.:.||:..:.:.|:...... |...|......|.|:::
  Fly   596 GDPCPQPMQLNATELEPCTYLEGYDYFSGSELMFIYVCVFLGFVPILCAGAGYCVVKLQNSKRRR 660

Human  1319 --------RSAQYSYPVDKDM--ELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQ 1373
                    |:.|:...|||.:  |..|...::...:..|.:|...||..|   .:...||:.:..
  Fly   661 LKIRQEALRAPQHKGSVDKMLAREWLHANHKRLVTVKFGPEAAIYTVDRK---GEKLRTFSLKHI 722

Human  1374 ETITALREQINKLEAR 1389
            :.::......|.::.:
  Fly   723 DVVSVEESATNHIKKK 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PXDNL	NP_653252.4	LRR	<36..>194	CDD:443914
		LRR 1	51..72
		leucine-rich repeat	52..85	CDD:275378
		LRR 2	75..96
		leucine-rich repeat	86..123	CDD:275378
		LRR 3	99..120
		LRR_8	123..182	CDD:404697
		LRR 4	123..144
		leucine-rich repeat	124..147	CDD:275378
		LRR 5	147..168
		leucine-rich repeat	148..171	CDD:275378
		leucine-rich repeat	172..184	CDD:275378
		LRRCT	180..232	CDD:214507
		Ig_3	234..309	CDD:464046
		Ig_3	329..402	CDD:464046
		Ig	432..505	CDD:472250
		Ig strand B	436..440	CDD:409353
		Ig strand C	449..453	CDD:409353
		Ig strand E	471..475	CDD:409353
		Ig strand F	485..490	CDD:409353
		Ig strand G	499..502	CDD:409353
		Ig	528..596	CDD:472250
		Ig strand B	528..532	CDD:409353
		Ig strand C	541..545	CDD:409353
		Ig strand E	563..567	CDD:409353
		Ig strand F	577..582	CDD:409353
		Ig strand G	591..594	CDD:409353
		peroxidasin_like	851..1286	CDD:188658	141/476 (30%)
		VWC	1400..1450	CDD:214564
Duox	NP_608715.2	dual_peroxidase_like	72..625	CDD:188652	167/597 (28%)
		PTZ00184	807..965	CDD:185504
		EFh	860..921	CDD:238008
		PLN02844	<1081..>1393	CDD:215453
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783