Protein Alignment CPT1A and ChAT

DIOPT Version :10

• Sequence 1: NP_001867.2
• Gene: CPT1A / 1374
• HGNCID: 2328
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_477004.5
• Gene: ChAT / 42249
• FlyBaseID: FBgn0000303
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 667
• Identity: 190/667 - (28%)
• Similarity: 313/667 - (46%)
• Gaps: 102/667 - (15%)

Human   165 YSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAV--GLGPRLQWYLKLKSWW 227
            :.|..:||::||||:.:|:..|::::.|:......:|...|.:.|:.  |:|.||..||..|...
  Fly    82 FGFPDTLPKVPVPALDETMADYIRALEPITTPAQLERTKELIRQFSAPQGIGARLHQYLLDKREA 146

Human   228 ATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILP------THIQAARAGNAIHAILLYRRKL 286
            ..|:...:|...:|:..|.||.:|||..     .:.|      .|..|..|...:..||.:|..|
  Fly   147 EDNWAYYYWLNEMYMDIRIPLPINSNPG-----MVFPPRRFKTVHDVAHFAARLLDGILSHREML 206

Human   287 DREEIKPIRLLGS---TIPLCSAQWERMFNTSRIPGEETD-----TIQHMRD-SKHIVVYHRGRY 342
            |..|: |:....|   ..|||.||:.|:..:.|.||.:.|     :.:.:.| .:|:||..|.:.
  Fly   207 DSGEL-PLERAASREKNQPLCMAQYYRLLGSCRRPGVKQDSQFLPSRERLNDEDRHVVVICRNQM 270

Human   343 FKVWLYHDGR-LLKPREMEQQMQRILDNT----SEPQPGEARLAALTAGDRVPWARCRQAYFGRG 402
            :.|.|....| .|...|:..|:..:|.:.    ::|.|    :..|||..|..|||.|:......
  Fly   271 YCVVLQASDRGKLSESEIASQILYVLSDAPCLPAKPVP----VGLLTAEPRSTWARDREMLQEDE 331

Human   403 KNKQSLDAVEKAAFFVTLDETEEG--------------YRSEDPD-TSMDSYAKSLLHG-----R 447
            :|:::|:.:|.|...:.|||...|              :|:.|.| |:|   |..::||     .
  Fly   332 RNQRNLELIETAQVVLCLDEPLAGNFNARGFTGATPTVHRAGDRDETNM---AHEMIHGGGSEYN 393

Human   448 CYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPNI 512
            ..:|||||:...::..:|..||..|||.::...|..|.|.:..  .::....||   .|....::
  Fly   394 SGNRWFDKTMQLIICTDGTWGLCYEHSCSEGIAVVQLLEKIYK--KIEEHPDED---NGLPQHHL 453

Human   513 PYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLA 577
            |.|.||:|.:..:.|.....:..:.:...:|:||:.:.:.::||..||.|:.|||.::|||||||
  Fly   454 PPPERLEWHVGPQLQLRFAQASKSVDKCIDDLDFYVYRYQSYGKTFIKSCQVSPDVYIQLALQLA 518

Human   578 HYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMV-----------DPAQTVEQRLK 631
            |||..|:...|||::.||.|..||.:.:|:.:||:.::.:||.           |.....|.|..
  Fly   519 HYKLYGRLVATYESASTRRFLHGRVDCIRAASTEALEWAKAMCQGEGANVPLESDREDEEESRKV 583

Human   632 LFKLASEKH-QHMYRLAMT-----------GSGIDRHLFCLYVVSKYLAVESPFL----KEVLSE 680
            .|.:.|:.| :.::|.|:.           |:|||..|..|...|..:..|...|    ..::|:
  Fly   584 KFSIYSKDHLRELFRCAVARQTEVMVKNILGNGIDIPLLGLREASIEVTGEMHELFKDESYIISQ 648

Human   681 PWRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKFSCPET 745
            .:.|||||....             ..|..|:|||...|||.||....|.:: |.:|:.:||.:|
  Fly   649 CFLLSTSQVACS-------------TDSFMGYGPVTPRGYGCSYNPHPEQIV-FCVSAFYSCEDT 699

Human   746 DSHRFGRHLKEAMTDII 762
            .:.|:.:.|:::: ||:
  Fly   700 SASRYAKSLQDSL-DIM 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPT1A	NP_001867.2	CPT_N	1..47	CDD:465132
		Carn_acyltransf	174..756	CDD:459926	185/650 (28%)
ChAT	NP_477004.5	Carn_acyltransf	92..710	CDD:459926	185/649 (29%)