Protein Alignment CPT1A and whd

DIOPT Version :10

• Sequence 1: NP_001867.2
• Gene: CPT1A / 1374
• HGNCID: 2328
• Length: 773
• Species: Homo sapiens
• Sequence 2: NP_001163111.1
• Gene: whd / 36109
• FlyBaseID: FBgn0261862
• Length: 782
• Species: Drosophila melanogaster
• Alignment Length: 774
• Identity: 393/774 - (50%)
• Similarity: 528/774 - (68%)
• Gaps: 21/774 - (2%)

Human     1 MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPAS-PSSWLI 64
            |||||.||||.|.:|.:|.|:...||.|..::.||:.||||:..|.:||:..|||||. .|.|||
  Fly     1 MAEAHAAVAFSFAITHEGFDINYDHEVLNLVWNSGVRSWKKRLARARNGVRNGVYPAHIQSLWLI 65

Human    65 --VVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTKN--VVSGVLFGTGLWVALIVTMRYS 125
              :.:|:....|.         |..|.|......:.|.|.|  |.:..|....:|:::..||||:
  Fly    66 SAIALGLHFAGYQ---------APFNLTNRILVHLPSNTINWQVTACFLAALVVWLSICFTMRYT 121

Human   126 LKVLLSYHGWMFTEHGKMSRA---TKIWMGMVKIFSG-RKPMLYSFQTSLPRLPVPAVKDTVNRY 186
            ||:||.|.|||:......||.   |.:|:.:|::.|. .||.|||||.||||||:|:||||:.||
  Fly   122 LKLLLMYKGWMYESRAPGSRVSLPTMLWVAVVRVLSSWNKPGLYSFQGSLPRLPLPSVKDTMTRY 186

Human   187 LQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVN 251
            |:|||||:.:|::.||..||::|...:|.:|||||.|||||:|||||||||||:|||||.||.||
  Fly   187 LRSVRPLLDDENYTRMERLAKEFEQTIGKKLQWYLILKSWWSTNYVSDWWEEYVYLRGRSPLCVN 251

Human   252 SNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSR 316
            ||:|..|.:::..|..|||||.|.|..:|.:||.::.:|::||.:.| .|||||.|:||.|||:|
  Fly   252 SNFYGTDAIFMNLTDKQAARAANVISLLLNFRRLIEHQELQPIMVQG-MIPLCSWQYERTFNTAR 315

Human   317 IPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRLLKPREMEQQMQRILDNTSEPQPGEARLA 381
            :||.|||.|.|.|||.||||.|:|.|:|:.:|:.||:|:|.|::.|::.||...:.|..||..||
  Fly   316 VPGLETDRIIHYRDSNHIVVLHKGCYYKMLIYYKGRILRPCELQVQIEEILKGKATPVEGEEHLA 380

Human   382 ALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYAKSLLHG 446
            ||||.:|..||..|..:|..|.|:.||..:|.|||.::||:....:....|:. :|::.|.||||
  Fly   381 ALTAWNRSKWAEARNTFFSWGVNQTSLRTIESAAFVLSLDDEPFEFDLARPEL-LDNFGKKLLHG 444

Human   447 RCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPN 511
            ..|:|||||.||..|..||::|.||||:|:||.|.:|:||.::..|.:..||.|.|:.||.....
  Fly   445 NGYNRWFDKCFTVCVGTNGRVGFNAEHTWSDAAIASHMWENLIVDDLVSDGYDETGNTKGTPAFQ 509

Human   512 IPYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQL 576
            .|.||||.||:.....::.|.:::...|: |:|:........:|||.:||||.||||::|:||||
  Fly   510 PPTPTRLTWDLKPCLAQIEEATIDVTKLI-NEVNLRILVHQDYGKGFMKKCRISPDAYIQMALQL 573

Human   577 AHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPAQTVEQRLKLFKLASEKHQ 641
            |:|:|.|:|.||||||||||||||||||||.||.||..:|:||.:|..|.::|:|:.:.|.::||
  Fly   574 AYYRDAGRFSLTYEASMTRLFREGRTETVRPCTIESSAWVKAMQNPNTTNDERVKMMQAACDRHQ 638

Human   642 HMYRLAMTGSGIDRHLFCLYVVSKYLAVESPFLKEVLSEPWRLSTSQTPQQQVELFDLENNPEYV 706
            ..|:.||.|.||||||||||||||||.|:||||.|||||||||||||||..|....||:.:|..:
  Fly   639 LGYQDAMCGRGIDRHLFCLYVVSKYLEVDSPFLNEVLSEPWRLSTSQTPHGQTPKMDLKKHPNCI 703

Human   707 SSGGGFGPVADDGYGVSYILVGENLINFHISSKFSCPETDSHRFGRHLKEAMTDIITLF 765
            |:|||||||||||||||||:.|||||.||||:|.:|.:||.|||.:::.:|::||.::|
  Fly   704 SAGGGFGPVADDGYGVSYIIAGENLIFFHISAKTTCQQTDVHRFAQNISQALSDIRSMF 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPT1A	NP_001867.2	CPT_N	1..47	CDD:465132	23/45 (51%)
		Carn_acyltransf	174..756	CDD:459926	315/581 (54%)
whd	NP_001163111.1	CPT_N	1..47	CDD:465132	23/45 (51%)
		Carn_acyltransf	174..753	CDD:459926	315/581 (54%)