DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgre1 and mthl1

DIOPT Version :9

Sequence 1:	NP_001342651.1	Gene:	Adgre1 / 13733	MGIID:	106912	Length:	931	Species:	Mus musculus
Sequence 2:	NP_001285340.1	Gene:	mthl1 / 32637	FlyBaseID:	FBgn0030766	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	87/382 - (22%)
Similarity:	154/382 - (40%)	Gaps:	74/382 - (19%)

- Green bases have known domain annotations that are detailed below.

Mouse   579 YTLQHIQPKQKSERPICVSWNTDVEDGRWTPSGCEIVEASETHTVCSCNRMANLAIIMASGELTM 643
            |.|:|.|.:.:.:...|....:       :.:|..|.:.|...|:...|.. ||...:.:|
  Fly   282 YCLEHTQREGEVKIIACQHLFS-------SAAGAGIHDGSIGGTIEQANGQ-NLQKAVLTG---- 334

Mouse   644 EFSLYIISHVGTVISLVCLALAIATFLLCRAVQNHNTYMHLHLC--VCLFLAKILFLTGIDKTDN 706
                      |.::|:|.|:..:....|..|| :|..:....:|  .||...|||.  .|::..:
  Fly   335 ----------GILVSIVFLSATLVAGFLLPAV-HHALHWRCQICYVTCLLFGKILL--AIEELSS 386

Mouse   707 -----QTACAIIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLH---LCAFGY 763
                 ..||..:|..:.:.|||.|||:......::...|:.:..:.  .||.:.|.   ...:.:
  Fly   387 SLQPGSAACHTLAITMQFFFLAAFFWLNTMCFNIWWTFRDFRPSSL--ERNQEALRRYLYSLYAW 449

Mouse   764 GLPVLVVIISASVQ--PR------GYGMHNRCWLNTETGFIWS-FLGPVCMIITINSVLLAWTLW 819
            |.|:|:..::|.|.  |.      |:| ...||.:.....|:: |.||:.:::..|..|...|
  Fly   450 GGPLLITFVAACVDQLPETTLLRPGFG-QLYCWFDNRNLSIFAYFYGPIGLLLCANIALFVST-- 511

Mouse   820 VLRQKLCSV--SSEVSKLKDTRLLTFKAIAQIFILGCSWVLGIFQI---GPLASIMAYLFT-IIN 878
             ..|..|.:  ..:|....:...|....:..:.::|.:|:..|...   ||..   .:.|| :||
  Fly   512 -THQLTCGLWKRDDVKSSSEKSALGRVCLKLVVVMGVTWIADILSWLVGGPHG---VWFFTDLIN 572

Mouse   879 SLQGAFIFL-IHCLLNRQVRDEYKKL--------LTRKTDLSSHSQTSGILLSSMPS 926
            :|||.|||: :.|  ..||....:::        :|..|:...||.:|    ..:||
  Fly   573 ALQGVFIFIVVGC--QPQVWTACRRIFCPRLRHDITNTTNGVQHSSSS----QGLPS 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgre1	NP_001342651.1	EGF_CA	33..63	CDD:238011
		EGF_CA	81..115	CDD:214542
		EGF_CA	133..172	CDD:214542
		EGF_CA	173..>203	CDD:214542
		EGF_CA	222..258	CDD:238011
		EGF_CA	272..>301	CDD:214542
		EGF_CA	319..352	CDD:214542
		Cell attachment site. /evidence=ECO:0000255	506..508
		GPS	591..640	CDD:197639	8/48 (17%)
		7tmB2_EMR	644..906	CDD:320555	67/295 (23%)
		TM helix 1	646..671	CDD:320555	4/24 (17%)
		TM helix 2	680..702	CDD:320555	6/23 (26%)
		TM helix 3	711..738	CDD:320555	7/26 (27%)
		TM helix 4	755..775	CDD:320555	4/22 (18%)
		TM helix 5	792..815	CDD:320555	6/23 (26%)
		TM helix 6	839..864	CDD:320555	4/27 (15%)
		TM helix 7	868..893	CDD:320555	11/26 (42%)
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	62/275 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810