DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ell and Su(Tpl)

DIOPT Version :9

Sequence 1:	NP_031950.2	Gene:	Ell / 13716	MGIID:	109377	Length:	602	Species:	Mus musculus
Sequence 2:	NP_001163477.1	Gene:	Su(Tpl) / 40171	FlyBaseID:	FBgn0014037	Length:	1059	Species:	Drosophila melanogaster

Alignment Length:	943	Identity:	197/943 - (20%)
Similarity:	322/943 - (34%)	Gaps:	371/943 - (39%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 SYGLS-CGRVSDGSRVSVFHVKLTDSALKAFESYRAHQDSVSLRP----SIRFEGSQGHISIPQP 68
            :||:| ..|.:|.|:..:. |||||||.:|.|.|:...::..|:|    .|:|.|:.|.|..|:|
  Fly    19 NYGMSQSHRYTDDSKEYII-VKLTDSAFRAIEEYQRDDNAKRLQPGQRAKIQFVGNTGVIQFPRP 82

Mouse    69 DCPEE-------------------VRAFSFYLSNIGRDSPQGSFDCIQQYVSSYGDVHLDCLGSI 114
            .....                   .|.|.|.::|:     :|:.:|:||...|.|     .||::
  Fly    83 ATDANGIPNANGNGSDATGAGGGGGRKFGFTINNM-----EGTLECVQQQQRSLG-----VLGAV 137

Mouse   115 QDKVTVCATDDSYQKARQSMAQAEEETRSRSAIVIKAGGRYMGKKVQ------------------ 161
            ..::.:.|.:|.|...|..||.|||..:|:....||.....:|:||:
  Fly   138 TLRMRIHANEDVYDSTRTKMAIAEETEKSKCIREIKPNQSDIGRKVKKPPSAIQSSASTASAFSS 202

Mouse   162 ----------------------------------------------------------------F 162
                                                                            .
  Fly   203 NSSNSGLTTTAFHHHSNSNNSGNNNNRSSSSSNSFNSNNHSRKLGSSPFNGLGVGSSSSSSAFAS 267

Mouse   163 RKPAP---------------------GAADAVPS-------------------------RKRATP 181
            |.|.|                     |||.::.|                         ...||.
  Fly   268 RSPNPSTLGAIGTVNGSGVVGGRYGGGAASSLASTFANGISQGYHNLSGSSPRDSMTAGTSSATA 332

Mouse   182 INLASAIRK------------------------SSGSGASSVVQRPFRDRVLHLLALRPYRKAEL 222
            .::.|:..|                        |.|:..|.|.:|..|:|::|||||:.::|.||
  Fly   333 SSVISSRNKMPSGGLTSSNSNSSSSSRSANSKSSGGNKMSDVSRRNIRERLIHLLALKAFKKPEL 397

Mouse   223 LLRLQKDGLTQADKDTLDSLLQQVASVNPKDGTCTLQDCMYKSLQKDWPGYSEGDRQLLKRMLMR 287
            ..||:.:|:...:::.:.::|..:::::  ..|..|:..|:..:.::||.:||.:.|.|||...:
  Fly   398 FARLKNEGIRDRERNQITNILMDISTMS--HNTYNLRRQMWNDVDENWPFFSEQEVQQLKRRKPQ 460

Mouse   288 KLCQPQ-----NATTDSSPPREHGRSASP-----------------SQKRPT-DFIDPLAS---- 325
            .|..|.     ::|:..||...|..|..|                 |.||.: ::.:.:.|
  Fly   461 NLTPPMSSDAGSSTSGQSPTSTHTGSPPPPSSNGGPGGVGSGAGGTSMKRTSLEYDETMFSTVQP 525

Mouse   326 KKPRISHFTQRAQPTLN-----------GKLGAPNGHETLLPAPGPTPSDTLSSSHLP------- 372
            ||.||||:.:...|:..           |..|:.:......|...|.|.|..|::.|.
  Fly   526 KKQRISHYKKDTPPSGTSYSSAGVSMSLGSSGSSSRSRYTPPQRQPGPLDDHSTTDLSYNVLDNI 590

Mouse   373 ---------------PRLEPPRTH--------DPLADVSN-----------------DLGHSTQD 397
                           .:.:.||::        ..||..||                 ..|:.||.
  Fly   591 VEFMSSTAAATQQSMEQQQHPRSNSSNNRRGSSSLAGTSNGGNNKDKRNSTGSNSSSSSGYETQQ 655

Mouse   398 YKHQEATP---------------------APAPHLGL----------PLLTD------------- 418
            .:.:..||                     .||...|.          |..:|
  Fly   656 DRQRSTTPMSSNRSSASSSTTPPKLAASFVPAATSGSASGTSKQRMPPQQSDYNSYNSNNAQHVA 720

Mouse   419 ------------------------------FPQAEQPTSSSHTHSRPKKKSKKH--KDKERPPEE 451
                                          :.|...|:|:|.:..:.:.:.:|.  :.|:.|.::
  Fly   721 SNSKKRMGSVGPSGGSNGQRQRSASGSNSGYQQVPPPSSNSRSSIQQQNQHQKQQVQQKQAPSQQ 785

Mouse   452 RPPA----------PQPDAPTAPALPPDAPGLNGACDNEPTSSSETPDY-LLKYPAISSSEQRQS 505
            :...          |.|....|.|....|   :...|   |.||.||.| ..:|..|.:.|.|:.
  Fly   786 QQQQQQQYHQQAKHPSPSQQLAAAAHAYA---HATAD---TDSSATPRYDFSQYVPIQTLEVRRR 844

Mouse   506 YKNDFNAEYSEYRSLHARIEQITRRFTQLDAQL---RQLSQGSDEYETTRGQILQEYRKIKKTNT 567
            ||.:|.::|.|||.|..|:|.:..||..|..:|   |:...|..:|:..:.||:.||.:|....|
  Fly   845 YKTEFESDYDEYRKLLTRVEDVRNRFQDLSERLESARRCDNGYGDYDHIKRQIVCEYERINNDRT 909

Mouse   568 NYSCEKRRCEYLHRKLAHIKRLIAEYDQRQLQA 600
             ...:|.|.:|||.||||||:|:.:||:..:.|
  Fly   910 -IGEDKERFDYLHAKLAHIKQLVMDYDKTLMSA 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ell	NP_031950.2	ELL	6..287	CDD:287376	93/453 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..489		59/367 (16%)
		Occludin_ELL	497..594	CDD:284669	38/99 (38%)
Su(Tpl)	NP_001163477.1	ELL	16..460	CDD:287376	93/453 (21%)
Su(Tpl)	NP_001163477.1	Occludin_ELL	836..935	CDD:284669	38/99 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836302
Domainoid	1	1.000	140	1.000	Domainoid score	I4746
eggNOG	1	0.900	-	-		E1_KOG4796
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4252
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D170004at33208
OrthoFinder	1	1.000	-	-		FOG0002166
OrthoInspector	1	1.000	-	-		otm43800
orthoMCL	1	0.900	-	-		OOG6_100830
Panther	1	1.100	-	-	O	PTHR23288
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5695
SonicParanoid	1	1.000	-	-		X1874
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.880