DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CPN2 and Fili

DIOPT Version :9

Sequence 1:	NP_001073982.3	Gene:	CPN2 / 1370	HGNCID:	2313	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	142/540 - (26%)
Similarity:	216/540 - (40%)	Gaps:	115/540 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     7 LLWTSLLLLARPAQPCPMGCDCFVQE----VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETR 67
            ||.|.::|.......||..|.|...|    ..|.|..|..||:.:.|.||.|........|||.
  Fly    27 LLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRTLEF- 90

Human    68 AFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSS---------FLNLSTNI------- 116
               |.|...|:..|:  |.|            ..:|..||.         .||||.|:
  Fly    91 ---SLPFYMKLEILD--LSQ------------NIIETLGSKNFEYQSELRTLNLSRNLVSSLHKH 138

Human   117 -FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180
             |..||:|..|.|:||.:|.:.......||:|..|.|..|.:.:|....|:.:..|:.|....|.
  Fly   139 AFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNR 203

Human   181 LAQLP-EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244
            |..:| ..|:| |.:|::|.:|.|.:..:....|..|..|..|.:..|.:|||....|..|..|:
  Fly   204 LLDVPASNLWH-LHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLK 267

Human   245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTH-NQLETVAEGT 308
            .|.|..|.:|.:|....:.|.|||:|:|..|....|||..|.:...|..|.|:. :.|:.:....
  Fly   268 HLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRA 332

Human   309 FAHLSNLRSLMLSYN-AITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
            |...::|::|.|:.| .::.:|..:|:....::::|:.||:|..|:.|.|. :.:|:
  Fly   333 FVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFP-VDQLQ-------- 388

Human   373 LTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLL--NIQTYCAGPAYLKGQVV 435
                            .|.|..||.||:|.|.:|  |      ||:  |.:....|..:..|..|
  Fly   389 ----------------KLYLGDNPLQCNCSLLWL--W------RLVTGNFEGVDPGMEHAAGGAV 429

Human   436 PAL----NEKQLVCPVTRDHLGFQVTWPDESKAGGSWD------------------LAVQERAAR 478
            .||    ::::|.               ||:.|..|.|                  |...|.:|.
  Fly   430 AALAKEADDEELA---------------DEATAVASTDDGVAALAAYIAEQHIVNALHTTEPSAY 479

Human   479 SQCTYSNPEGTVVLACDQAQ 498
            ...|.|:...:.:|..|:.|
  Fly   480 ELATSSSNRNSGILRMDRQQ 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPN2	NP_001073982.3	LRRNT	21..53	CDD:214470	12/35 (34%)
		leucine-rich repeat	30..53	CDD:275380	8/26 (31%)
		leucine-rich repeat	75..98	CDD:275380	4/22 (18%)
		LRR 1	98..119		9/37 (24%)
		leucine-rich repeat	99..122	CDD:275380	10/39 (26%)
		LRR_8	121..181	CDD:290566	18/59 (31%)
		LRR 2	122..143		6/20 (30%)
		leucine-rich repeat	123..146	CDD:275380	7/22 (32%)
		LRR 3	146..167		6/20 (30%)
		leucine-rich repeat	147..170	CDD:275380	6/22 (27%)
		LRR_RI	149..>356	CDD:238064	60/209 (29%)
		LRR_8	169..229	CDD:290566	17/60 (28%)
		LRR 4	170..191		6/21 (29%)
		leucine-rich repeat	171..194	CDD:275380	8/23 (35%)
		LRR 5	194..215		5/20 (25%)
		leucine-rich repeat	195..218	CDD:275380	6/22 (27%)
		LRR_8	218..277	CDD:290566	21/58 (36%)
		LRR 6	218..239		7/20 (35%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR 7	242..263		6/20 (30%)
		leucine-rich repeat	243..266	CDD:275380	7/22 (32%)
		LRR 8	266..287		10/20 (50%)
		leucine-rich repeat	267..290	CDD:275380	9/22 (41%)
		LRR 9	290..311		5/21 (24%)
		leucine-rich repeat	291..314	CDD:275380	5/23 (22%)
		LRR_8	294..349	CDD:290566	13/56 (23%)
		LRR 10	314..335		6/21 (29%)
		leucine-rich repeat	315..338	CDD:275380	6/23 (26%)
		LRR 11	338..359		7/20 (35%)
		leucine-rich repeat	339..359	CDD:275380	7/19 (37%)
		LRR 12	362..383		1/20 (5%)
		leucine-rich repeat	363..382	CDD:275380	1/18 (6%)
		leucine-rich repeat	387..399	CDD:275378	4/11 (36%)
		LRRCT	395..446	CDD:214507	17/56 (30%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	8/25 (32%)
		leucine-rich repeat	98..121	CDD:275380	6/36 (17%)
		LRR_8	120..180	CDD:404697	20/59 (34%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	56/193 (29%)
		leucine-rich repeat	170..193	CDD:275380	6/22 (27%)
		leucine-rich repeat	194..217	CDD:275380	8/23 (35%)
		leucine-rich repeat	218..265	CDD:275380	14/46 (30%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..338	CDD:275380	5/23 (22%)
		LRR_8	337..397	CDD:404697	17/84 (20%)
		leucine-rich repeat	339..360	CDD:275380	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D187891at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020