DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPN2 and Toll-6

DIOPT Version :9

Sequence 1:	NP_001073982.3	Gene:	CPN2 / 1370	HGNCID:	2313	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	131/478 - (27%)
Similarity:	202/478 - (42%)	Gaps:	121/478 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    33 VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLC----------- 86
            :.|:||.:|.                   :.||.::|.   :|.::..|:.|.|
  Fly   125 ILCNDEIMAK-------------------SRLEAQSFA---HLVRLQQLSIQYCKLGRLGRQVLD 167

Human    87 ----------------------QFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLN 129
                                  :...|||....|||.|:::.::..:|..|||..|:.|..|.::
  Fly   168 GLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMS 232

Human   130 FNMLEALPEGLFQHLAA-----------------------------LESLHLQGNQLQALPRRLF 165
            .|.|:.:.|..|:..:.                             ||.|.:..|....||...|
  Fly   233 ENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGF 297

Human   166 QPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGS-LQELFLDSNNI 229
            ..|..|:.|::..|.::.:.::....|.:||.|.||:|.:..||..:|.:... :||::|.:|:|
  Fly   298 GTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSI 362

Human   230 SELPPQVFSQLFCLERLWLQRNAITH--LPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLV 292
            |.|.||:||.|..|:.|.|..|.||.  :..:.|..|..|..|:|..|.|..|...:|:....|.
  Fly   363 SVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQ 427

Human   293 GLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALF 357
            .|:|.|||||.:|..|||.::||.:|:||:|.:.:|.|.....|..|..|.|.:|.|..:||..|
  Fly   428 ILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAF 492

Human   358 QNLSKLELLSLSKNQLTTLP-----------------------EGIFDTNYNLFNLALHGNPWQC 399
            :|.|.|:.|:|:.|||.|:|                       :..|....||:.|.|.||
  Fly   493 RNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGN---- 553

Human   400 DCHLAYLFNWLQQYTDR-LLNIQ 421
                 ||.| :..:|.| |.|:|
  Fly   554 -----YLEN-ITMHTFRDLPNLQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPN2	NP_001073982.3	LRRNT	21..53	CDD:214470	4/19 (21%)
		leucine-rich repeat	30..53	CDD:275380	4/19 (21%)
		leucine-rich repeat	75..98	CDD:275380	7/55 (13%)
		LRR 1	98..119		8/20 (40%)
		leucine-rich repeat	99..122	CDD:275380	8/22 (36%)
		LRR_8	121..181	CDD:290566	17/88 (19%)
		LRR 2	122..143		6/20 (30%)
		leucine-rich repeat	123..146	CDD:275380	6/22 (27%)
		LRR 3	146..167		7/49 (14%)
		leucine-rich repeat	147..170	CDD:275380	8/22 (36%)
		LRR_RI	149..>356	CDD:238064	74/209 (35%)
		LRR_8	169..229	CDD:290566	17/60 (28%)
		LRR 4	170..191		3/20 (15%)
		leucine-rich repeat	171..194	CDD:275380	4/22 (18%)
		LRR 5	194..215		9/20 (45%)
		leucine-rich repeat	195..218	CDD:275380	9/22 (41%)
		LRR_8	218..277	CDD:290566	24/61 (39%)
		LRR 6	218..239		10/21 (48%)
		leucine-rich repeat	219..242	CDD:275380	12/22 (55%)
		LRR 7	242..263		7/22 (32%)
		leucine-rich repeat	243..266	CDD:275380	8/24 (33%)
		LRR 8	266..287		7/20 (35%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		LRR 9	290..311		11/20 (55%)
		leucine-rich repeat	291..314	CDD:275380	12/22 (55%)
		LRR_8	294..349	CDD:290566	24/54 (44%)
		LRR 10	314..335		8/20 (40%)
		leucine-rich repeat	315..338	CDD:275380	8/22 (36%)
		LRR 11	338..359		8/20 (40%)
		leucine-rich repeat	339..359	CDD:275380	8/19 (42%)
		LRR 12	362..383		9/43 (21%)
		leucine-rich repeat	363..382	CDD:275380	8/41 (20%)
		leucine-rich repeat	387..399	CDD:275378	5/11 (45%)
		LRRCT	395..446	CDD:214507	9/28 (32%)
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	3/22 (14%)
		LRR_8	171..236	CDD:290566	15/64 (23%)
		leucine-rich repeat	172..201	CDD:275380	3/28 (11%)
		leucine-rich repeat	202..278	CDD:275380	14/75 (19%)
		leucine-rich repeat	229..249	CDD:275380	5/19 (26%)
		LRR_RI	278..468	CDD:238064	68/189 (36%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	301..386	CDD:290566	29/84 (35%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR	350..729	CDD:227223	81/231 (35%)
		leucine-rich repeat	352..375	CDD:275380	12/22 (55%)
		leucine-rich repeat	376..401	CDD:275380	8/24 (33%)
		LRR_RI	<401..626	CDD:238064	61/180 (34%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	12/22 (55%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	9/22 (41%)
		leucine-rich repeat	498..518	CDD:275380	8/19 (42%)
		leucine-rich repeat	521..544	CDD:275380	1/22 (5%)
		leucine-rich repeat	545..566	CDD:275380	10/30 (33%)
		leucine-rich repeat	569..592	CDD:275380	1/2 (50%)
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8435
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910