DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CPN2 and CG32055

DIOPT Version :9

Sequence 1:	NP_001073982.3	Gene:	CPN2 / 1370	HGNCID:	2313	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	446	Identity:	128/446 - (28%)
Similarity:	193/446 - (43%)	Gaps:	66/446 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    49 PYTKNIIFVETSF------TTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGS 107
            |....:|..:.|:      ||.....||   ||....|....:....|:||..:..|.
  Fly   119 PNPSEMINFDVSYNDILAITTKLMSGFG---NLVYANFSENLIAVIEPNAFRHMKNLR------- 173

Human   108 SFLNLSTNIFSNLTSLGK------LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQ 166
             ||:|:||...|:| ||:      |:::.|.|........:.|..||.|||..|.|:.|...:|.
  Fly   174 -FLDLTTNYQENIT-LGENANLRFLSISNNNLRDFQWCHLRVLPKLEELHLHSNWLEHLDMGIFY 236

Human   167 PLTHLKTLNLAQNLLAQLPEELF---HPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNN 228
            .|.:|:.||::.|.|.::...||   ..:..|:.|..|:|.:..|...||.:|..|:.|.|..|.
  Fly   237 ALPNLRVLNVSNNNLFEIKRTLFMAPGEIAPLELLDYSSNIVKVLDDSVFCRLKKLRTLNLWLNQ 301

Human   229 ISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPC--L 291
            |:.:.|:.|..|..|:.|.||.|.|:.||..:||:|..|..|.|..|.::.|...:|.....  |
  Fly   302 INRIHPRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEKLDLSKNNIQKLGLRVFGERILRKL 366

Human   292 VGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPAL 356
            :.|.|::|.:..:.....:.:..::.|.|..|.:..|...:|..|.:|..|.:..|.|..:...:
  Fly   367 IYLDLSNNYIADLHPLALSSMPFIKELRLRRNRLVSLDLRMFAPLRQLQLLTINENRLEEIDGEI 431

Human   357 FQNLSKLELLSLSKNQLTTLPEGIFDTNYNLF---NLALHGNPWQCDCHLAYLFNWLQQYTDRLL 418
            ...|.:|..|.|:.|:||.||:  ..::.||.   |:.|.||||||.|        |.:.|..|.
  Fly   432 LDTLDRLNHLELNNNRLTFLPD--LKSSQNLLQLRNITLEGNPWQCLC--------LDEITSWLN 486

Human   419 NIQTYCAGP--AYLKGQVVPALNEKQLVCPVT------RDHLGFQVTWPDESKAGG 466
            ......|.|  ||..|        ::.:|.||      ||        ..|:||.|
  Fly   487 GRHVSYARPSSAYFSG--------RKPLCVVTPMDKCLRD--------LQETKAQG 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPN2	NP_001073982.3	LRRNT	21..53	CDD:214470	1/3 (33%)
		leucine-rich repeat	30..53	CDD:275380	1/3 (33%)
		leucine-rich repeat	75..98	CDD:275380	5/22 (23%)
		LRR 1	98..119		6/20 (30%)
		leucine-rich repeat	99..122	CDD:275380	7/22 (32%)
		LRR_8	121..181	CDD:290566	21/65 (32%)
		LRR 2	122..143		5/26 (19%)
		leucine-rich repeat	123..146	CDD:275380	6/28 (21%)
		LRR 3	146..167		9/20 (45%)
		leucine-rich repeat	147..170	CDD:275380	10/22 (45%)
		LRR_RI	149..>356	CDD:238064	62/211 (29%)
		LRR_8	169..229	CDD:290566	19/62 (31%)
		LRR 4	170..191		7/23 (30%)
		leucine-rich repeat	171..194	CDD:275380	7/25 (28%)
		LRR 5	194..215		7/20 (35%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		LRR_8	218..277	CDD:290566	23/58 (40%)
		LRR 6	218..239		7/20 (35%)
		leucine-rich repeat	219..242	CDD:275380	8/22 (36%)
		LRR 7	242..263		9/20 (45%)
		leucine-rich repeat	243..266	CDD:275380	11/22 (50%)
		LRR 8	266..287		6/20 (30%)
		leucine-rich repeat	267..290	CDD:275380	6/22 (27%)
		LRR 9	290..311		4/22 (18%)
		leucine-rich repeat	291..314	CDD:275380	4/22 (18%)
		LRR_8	294..349	CDD:290566	12/54 (22%)
		LRR 10	314..335		5/20 (25%)
		leucine-rich repeat	315..338	CDD:275380	6/22 (27%)
		LRR 11	338..359		4/20 (20%)
		leucine-rich repeat	339..359	CDD:275380	4/19 (21%)
		LRR 12	362..383		8/20 (40%)
		leucine-rich repeat	363..382	CDD:275380	8/18 (44%)
		leucine-rich repeat	387..399	CDD:275378	7/14 (50%)
		LRRCT	395..446	CDD:214507	14/52 (27%)
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380
		leucine-rich repeat	100..123	CDD:275380	1/3 (33%)
		LRR_8	128..180	CDD:290566	15/62 (24%)
		leucine-rich repeat	128..147	CDD:275380	5/21 (24%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		leucine-rich repeat	172..192	CDD:275380	10/28 (36%)
		LRR_RI	<187..400	CDD:238064	63/212 (30%)
		LRR_8	192..251	CDD:290566	18/58 (31%)
		leucine-rich repeat	193..216	CDD:275380	4/22 (18%)
		leucine-rich repeat	217..240	CDD:275380	10/22 (45%)
		leucine-rich repeat	241..267	CDD:275380	7/25 (28%)
		leucine-rich repeat	268..291	CDD:275380	8/22 (36%)
		LRR_8	290..350	CDD:290566	23/59 (39%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		leucine-rich repeat	316..339	CDD:275380	11/22 (50%)
		LRR_8	340..400	CDD:290566	13/59 (22%)
		leucine-rich repeat	340..365	CDD:275380	6/24 (25%)
		leucine-rich repeat	366..389	CDD:275380	4/22 (18%)
		leucine-rich repeat	390..413	CDD:275380	6/22 (27%)
		LRR_8	391..448	CDD:290566	15/56 (27%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910