Protein Alignment CPN2 and Toll-7

DIOPT Version :9

• Sequence 1: NP_001073982.3
• Gene: CPN2 / 1370
• HGNCID: 2313
• Length: 545
• Species: Homo sapiens
• Sequence 2: NP_523797.1
• Gene: Toll-7 / 37272
• FlyBaseID: FBgn0034476
• Length: 1446
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 110/361 - (30%)
• Similarity: 156/361 - (43%)
• Gaps: 45/361 - (12%)

Human    96 LPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQAL 160
            |.||:.|.:..::...||....:.|.||..:.|:.|.||.||||||.....|..:|||.|:|..|
  Fly   271 LRRLQHLNLAYNNLSELSGEALAGLASLRIVNLSNNHLETLPEGLFAGSKELREIHLQQNELYEL 335

Human   161 PRRLFQPLTHLK--------------------------TLNLAQNLLAQLPEELFHPLTSLQTLK 199
            |:.||..|..|.                          .||||.|.|.::....|..|..||.|.
  Fly   336 PKGLFHRLEQLLVVDLSGNQLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILN 400

Human   200 LSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
            |.||::..:....|..|.:|..|.|..|.:..|..::|:.|:.|.:|.|..|.|:.:..::|.:.
  Fly   401 LRNNSIGHIEDNAFLPLYNLHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNC 465

Human   265 GNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
            .:|..|.|..|.|..:|..| .....|..|.|..||:.|....:|.:|..|..|.|..|.|.::.
  Fly   466 SDLKELDLSSNQLNEVPRAL-QDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNIT 529

Human   330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHG 394
            .|:|:||..|..|.|..|.:.::....|....:||.:.|.:|.|..: .|:|.|..:|..|.|..
  Fly   530 VGMFQDLPRLSVLNLAKNRIQSIERGSFDKNFELEAIRLDRNFLADI-NGVFATLVSLLWLNLSE 593

Human   395 NPWQCDCHLA---YLF-----NWLQ---QYTDRLLN 419
            |      ||.   |.|     .||.   .|.:.|.|
  Fly   594 N------HLVWFDYAFIPSNLKWLDIHGNYIEALGN 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CPN2	NP_001073982.3	LRRNT	21..53	CDD:214470
		leucine-rich repeat	30..53	CDD:275380
		leucine-rich repeat	75..98	CDD:275380	1/1 (100%)
		LRR 1	98..119		5/20 (25%)
		leucine-rich repeat	99..122	CDD:275380	5/22 (23%)
		LRR_8	121..181	CDD:290566	29/85 (34%)
		LRR 2	122..143		12/20 (60%)
		leucine-rich repeat	123..146	CDD:275380	11/22 (50%)
		LRR 3	146..167		10/20 (50%)
		leucine-rich repeat	147..170	CDD:275380	11/22 (50%)
		LRR_RI	149..>356	CDD:238064	68/232 (29%)
		LRR_8	169..229	CDD:290566	21/85 (25%)
		LRR 4	170..191		8/46 (17%)
		leucine-rich repeat	171..194	CDD:275380	9/48 (19%)
		LRR 5	194..215		7/20 (35%)
		leucine-rich repeat	195..218	CDD:275380	8/22 (36%)
		LRR_8	218..277	CDD:290566	17/58 (29%)
		LRR 6	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR 7	242..263		6/20 (30%)
		leucine-rich repeat	243..266	CDD:275380	6/22 (27%)
		LRR 8	266..287		7/20 (35%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		LRR 9	290..311		7/20 (35%)
		leucine-rich repeat	291..314	CDD:275380	8/22 (36%)
		LRR_8	294..349	CDD:290566	20/54 (37%)
		LRR 10	314..335		7/20 (35%)
		leucine-rich repeat	315..338	CDD:275380	9/22 (41%)
		LRR 11	338..359		5/20 (25%)
		leucine-rich repeat	339..359	CDD:275380	5/19 (26%)
		LRR 12	362..383		7/20 (35%)
		leucine-rich repeat	363..382	CDD:275380	6/18 (33%)
		leucine-rich repeat	387..399	CDD:275378	4/11 (36%)
		LRRCT	395..446	CDD:214507	10/36 (28%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566
		leucine-rich repeat	136..159	CDD:275380
		leucine-rich repeat	160..190	CDD:275380
		LRR_8	189..259	CDD:290566
		leucine-rich repeat	191..214	CDD:275380
		leucine-rich repeat	215..248	CDD:275380
		LRR_RI	247..501	CDD:238064	71/230 (31%)
		LRR_8	247..308	CDD:290566	11/36 (31%)
		leucine-rich repeat	249..273	CDD:275380	1/1 (100%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		LRR_8	297..356	CDD:290566	24/58 (41%)
		leucine-rich repeat	298..321	CDD:275380	11/22 (50%)
		leucine-rich repeat	322..345	CDD:275380	11/22 (50%)
		LRR_8	345..406	CDD:290566	15/60 (25%)
		leucine-rich repeat	346..371	CDD:275380	1/24 (4%)
		leucine-rich repeat	372..395	CDD:275380	8/22 (36%)
		leucine-rich repeat	396..419	CDD:275380	8/22 (36%)
		LRR_8	419..478	CDD:290566	17/58 (29%)
		leucine-rich repeat	420..443	CDD:275380	7/22 (32%)
		leucine-rich repeat	444..467	CDD:275380	6/22 (27%)
		LRR_RI	466..622	CDD:238064	48/163 (29%)
		leucine-rich repeat	468..488	CDD:275380	7/20 (35%)
		LRR_8	491..549	CDD:290566	21/57 (37%)
		leucine-rich repeat	491..514	CDD:275380	8/22 (36%)
		leucine-rich repeat	515..536	CDD:275380	7/20 (35%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	8/22 (36%)
		leucine-rich repeat	586..626	CDD:275380	13/44 (30%)
		leucine-rich repeat	627..653	CDD:275380
		LRRCT	716..772	CDD:214507
		LRRNT	796..830	CDD:214470
		leucine-rich repeat	812..829	CDD:275380
		leucine-rich repeat	833..854	CDD:275380
		LRR_8	853..913	CDD:290566
		leucine-rich repeat	855..878	CDD:275380
		LRR_4	878..918	CDD:289563
		leucine-rich repeat	879..902	CDD:275380
		leucine-rich repeat	903..926	CDD:275380
		leucine-rich repeat	927..953	CDD:275380
		TIR	1098..1235	CDD:214587

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8435
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010