DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPN1 and svr

DIOPT Version :9

Sequence 1:	NP_001299.1	Gene:	CPN1 / 1369	HGNCID:	2312	Length:	458	Species:	Homo sapiens
Sequence 2:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster

Alignment Length:	460	Identity:	188/460 - (40%)
Similarity:	257/460 - (55%)	Gaps:	47/460 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    18 VAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYV 82
            :.|..:.||.:..:...|..:.:..|.:||:||||:||:||.|:|||....||.|.|..||.|||
  Fly   449 LTPTKYEHHNFTAMESYLRAISSSYPSLTRLYSIGKSVQGRDLWVLEIFATPGSHVPGVPEFKYV 513

Human    83 GNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGY 147
            .||||||.:|:||:|.|::::.|.:.| :.||.:|:..||:|.|.||||||||: :.:|....|
  Fly   514 ANMHGNEVVGKELLLILTKYMLERYGN-DDRITKLVNGTRMHFLYSMNPDGYEI-SIEGDRTGG- 575

Human   148 LVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLS 212
             |||.||:|:||||||||         :||        .|.:....|||..||:.|..|..||||
  Fly   576 -VGRANAHGIDLNRNFPD---------QYG--------TDRFNKVTEPEVAAVMNWTLSLPFVLS 622

Human   213 ANLHGGAVVANYPYD---KSFEHRVRGVRRTA-----STPTPDDKLFQKLAKVYSYAHGWMFQGW 269
            ||||||::|||||:|   ..|......:|.::     ..||.|:.||:.||.:||.||..|:.|.
  Fly   623 ANLHGGSLVANYPFDDNENDFNDPFMRLRNSSINGRKPNPTEDNALFKHLAGIYSNAHPTMYLGQ 687

Human   270 NC----GDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREA 330
            .|    .::|||||||||.|||::.||||:||:...|.|:|:|:.|||||...||.|.|..:||.
  Fly   688 PCELFQNEFFPDGITNGAQWYSVTGGMQDWNYVRAGCLELTIEMGCDKFPKAAELSRYWEDHREP 752

Human   331 LIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYD 395
            |:||:||||.||.|.|.......:|.||:.:.|.||...|...|||::|.|||.:.::.....|.
  Fly   753 LLQFIEQVHCGIHGFVHSTIGTPIAGAVVRLDGANHSTYSQVFGDYWKLALPGRHNLTVLGDNYA 817

Human   396 PETVTVTVGPAEPTLVNFHLKRSIPQV--SPVRRAPSRRHGV-------RAKVQPQARKKEMEMR 451
            |..:.|.|....|    |.::..|..:  .|...|.:....:       |....||.|.:..|:.
  Fly   818 PLRMEVEVPDVHP----FEMRMDITLMPDDPQHWASANDFRIIENVVNTRYHTNPQVRARLAELE 878

Human   452 QLQRG 456
            . |.|
  Fly   879 N-QNG 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPN1	NP_001299.1	Catalytic	21..340		152/330 (46%)
		M14_CPN	25..337	CDD:199846	149/323 (46%)
		Peptidase_M14NE-CP-C_like	341..415	CDD:200604	24/73 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..458		9/41 (22%)
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604
		M14_CP_N-E_like	456..759	CDD:199842	149/323 (46%)
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604	25/79 (32%)
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10989
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11532
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3496
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950