DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Eif4e and eIF4E4

DIOPT Version :9

Sequence 1:	XP_006501056.1	Gene:	Eif4e / 13684	MGIID:	95305	Length:	230	Species:	Mus musculus
Sequence 2:	NP_648052.1	Gene:	eIF4E4 / 38743	FlyBaseID:	FBgn0035709	Length:	229	Species:	Drosophila melanogaster

Alignment Length:	223	Identity:	100/223 - (44%)
Similarity:	141/223 - (63%)	Gaps:	8/223 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse    13 KMATVEPETTPTTNPPPAEEEKTESNQEVANP-----EHYIKHPLQNRWALWFFKNDKSKTWQAN 72
            ||.....||...:....:|:.||.|:.::..|     :..:||||:|.|.||:.:||:||.|:..
  Fly    10 KMMDNGTETLADSPSSSSEDLKTLSDMDIRKPVTEIVDLRLKHPLENTWTLWYLENDRSKNWEDM 74

Mouse    73 LRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRS 137
            ...|:.||.|||||:|||||:..|.:..|.||||||.||:|||||:.||.||||:|.:.:.. ::
  Fly    75 QNEITSFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDANKFGGRWVINMGRGS-KA 138

Mouse   138 DLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGRVYKERLGL 202
            :||:.||:.||.||||:|:: :::|||||:|:|.|.:||:|||....|..||..||...::.|.|
  Fly   139 ELDKLWLDVLLILIGEAFEN-TEEVCGAVINLRGKSNKISIWTANGHNELAVMEIGLKLRDLLVL 202

Mouse   203 PPKIVIGYQSHADTATKSGSTTKNRFVV 230
            ||. .:.||.|.||..|.||..|..:.|
  Fly   203 PPH-QLQYQLHKDTMCKQGSVIKAVYCV 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eif4e	XP_006501056.1	IF4E	51..210	CDD:366742	79/158 (50%)
eIF4E4	NP_648052.1	IF4E	56..209	CDD:279921	77/155 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830801
Domainoid	1	1.000	186	1.000	Domainoid score	I3337
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	215	1.000	Inparanoid score	I3600
Isobase	1	0.950	-	0	Normalized mean entropy	S964
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm8694
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750