DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CPM and svr

DIOPT Version :9

Sequence 1:	NP_001005502.1	Gene:	CPM / 1368	HGNCID:	2311	Length:	443	Species:	Homo sapiens
Sequence 2:	NP_001284744.1	Gene:	svr / 30998	FlyBaseID:	FBgn0004648	Length:	1439	Species:	Drosophila melanogaster

Alignment Length:	412	Identity:	173/412 - (41%)
Similarity:	249/412 - (60%)	Gaps:	33/412 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    21 NYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGD 85
            :|..||.:|.....:.:.|.:...:|.:|:|::||||..|.:.|..:...:..|..||:||||||
  Fly    39 HYASQEQLEDLFAGLEKAYPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLTPPVKYIANMHGD 103

Human    86 ETVGRELLLHLIDYLVTSDGKDPEITNLINSTRIHIMPSMNPDGFEAVKKPDC-----YYSIGRE 145
            |||||:||:::..||:.:..:..::..|:|||.|:::|:|||||:...::.:|     |  :||.
  Fly   104 ETVGRQLLVYMAQYLLGNHERISDLGQLVNSTDIYLVPTMNPDGYALSQEGNCESLPNY--VGRG 166

Human   146 NYNQYDLNRNFPDAFEYNNV------SRQPETVAVMKWLKTETFVLSANLHGGALVASYPFDNGV 204
            |....||||:|||..|.::|      ||||||.|::.|:.::.||||||.||||:|||||:||.:
  Fly   167 NAANIDLNRDFPDRLEQSHVHQLRAQSRQPETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSL 231

Human   205 QATGALYSRSLTPDDDVFQYLAHTYASRNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYN 269
             |.......||||||.||:.|||||:..:|.|:||:.|.:  :|..|:|||..||.|.|||||:|
  Fly   232 -AHNECCEESLTPDDRVFKQLAHTYSDNHPIMRKGNNCND--SFSGGITNGAHWYELSGGMQDFN 293

Human   270 YIWAQCFEITLELSCCKYPREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPL--PNVIV 332
            |.::.|||:|:||||||||....||..|..|||||::.::|.|:|:||.|.|.:|.|:  .||.|
  Fly   294 YAFSNCFELTIELSCCKYPAASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYV 358

Human   333 EVQDRKHICPYRTNKYGEYYLLLLPGSYIINVTVPGHD---PHITKVIIPEKSQNFSALKKDILL 394
            ...:.|   |.||:|.|||:.||.||.|.::.:..|:.   |...:|    .:.|..||:.|..|
  Fly   359 AGLEEK---PMRTSKRGEYWRLLTPGLYSVHASAFGYQTSAPQQVRV----TNDNQEALRLDFKL 416

Human   395 P-----FQGQLDSIPVSNPSCP 411
            .     |.|....:.|.....|
  Fly   417 APVETNFDGNFRKVKVERSEPP 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPM	NP_001005502.1	M14_CPM	18..310	CDD:199848	136/299 (45%)
CPM	NP_001005502.1	Peptidase_M14NE-CP-C_like	314..394	CDD:200604	30/84 (36%)
svr	NP_001284744.1	M14_CPD_I	40..334	CDD:199850	136/298 (46%)
		Peptidase_M14NE-CP-C_like	338..416	CDD:200604	30/84 (36%)
		M14_CP_N-E_like	456..759	CDD:199842
		Peptidase_M14NE-CP-C_like	763..839	CDD:200604
		CarbopepD_reg_2	1125..1202	CDD:290434
		CarboxypepD_reg	1223..1301	CDD:290350
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2649
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4288
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101221at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3496
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.800