DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eif3a and eIF3a

DIOPT Version :9

Sequence 1:	NP_034253.3	Gene:	Eif3a / 13669	MGIID:	95301	Length:	1344	Species:	Mus musculus
Sequence 2:	NP_649470.2	Gene:	eIF3a / 40563	FlyBaseID:	FBgn0037249	Length:	1140	Species:	Drosophila melanogaster

Alignment Length:	1367	Identity:	564/1367 - (41%)
Similarity:	772/1367 - (56%)	Gaps:	251/1367 - (18%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTW-----QKIHEPIMLKYLELCVD 60
            |..|.|||||||||||||:||||...|||.|.:|.::|:   |     :.:.||:|.|||.|||:
  Fly     1 MARYTQRPENALKRANEFIEVGKPLRALDTLQEVFRNKR---WNYAYSETVIEPLMFKYLYLCVE 62

Mouse    61 LRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTEAAKEESQQ--MVLDIEDLDNIQT 123
            |:|||:|||||:||:|:.|.||:.|||:|:|.|||:|||.||||:.:|..  .||:::|||||.|
  Fly    63 LKKSHIAKEGLFQYRNMFQLVNVNSLENVIRGYLKMAEEHTEAAQAQSSAAVAVLELDDLDNIAT 127

Mouse   124 PESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQY 188
            |||:|:|||.|||.|||:||.:|.||||||||||.|||:|||.|:..|.||||||:.||:|||:|
  Fly   128 PESILMSAVCGEDAQDRSDRTILLPWVKFLWESYCQCLELLRVNTHCEALYHDIARMAFQFCLKY 192

Mouse   189 TRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAV 253
            .||:|||:|||.||.||..|.:..||:|.:::|..|:|.:.|:|||..|||||.|||||||:||:
  Fly   193 NRKSEFRRLCDKLRKHLEDICKSSNQTTGVSINKVETQQLCLDTRLYLLDSAIQMELWQEAYKAI 257

Mouse   254 EDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQEEMQRM 318
            ||||||.:||||.|.|:.|||||.|::.||.|:||.||||:.|.:|:.|:||::||||::::|||
  Fly   258 EDIHGLMALSKKTPVPKTMANYYQKLAMVFSKAGNQLFHAAALLKLFQLTRELKKNLTKDDLQRM 322

Mouse   319 STRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFSVLQYV 383
            :..|||||||||:.....:..|.::.|...:||.::||.||||..||||:.||.::||.:|.|.|
  Fly   323 AAHVLLATLSIPLPSAHPEFDRFIEADKSPLEKAQKLAVLLGLPQPPTRVSLIREVVRLNVPQLV 387

Mouse   384 VPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVAQIYQ 448
            ..:.::|||||||:||||.||:|:..:::::...|| ...|..|:..|::.||:||::|::|:|:
  Fly   388 SEDFRNLYNWLEVDFNPLNLCKRIQSIVDFIENGPE-NALLTPYIQSLKDVTIMRLIRQISQVYE 451

Mouse   449 SIEFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPVGPHLQS 513
            ||:|.||..|..|.:.|:||:.:|::.||.|:|:||||...::.||:||..:.||..|.||.|||
  Fly   452 SIKFQRLLQLASFCNIFELEKLLVESVRHNDMQIRIDHQKNSIYFGTDLTESQREYRPDGPALQS 516

Mouse   514 MPSEQIRNQLTAMSSVLAKALEVIRPAHILQEKEEQHQLAVNAYLKNSRKEHQRILARRQTIEER 578
            |||||||:||..||:||.:|:.::.|.....::.:.....||.|.:...:||||||.|::.||:|
  Fly   517 MPSEQIRSQLVNMSTVLTRAVSIVYPNRERDQRAKLRNQMVNHYHEIKDREHQRILQRQKIIEDR 581

Mouse   579 KERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQI 643
            ||.:|..|..||:||..::|.|.:|.:.||::||.||.:|||::|...|.:.|::|:::|:::||
  Fly   582 KEYIEKQNNAREEEEARRQEEESRKAKLAEQKRLEQEQEERERKRHQNEIQAIREKSLKEKVQQI 646

Mouse   644 KKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIP 708
            .:|..|.|....:|.|.:::||.:.|..::.|:|::|.||||.:||:||||||||||||||||||
  Fly   647 SQTAHGKKMLSKLDEEGIKKLDAEQIAKRESEELQREAKELQSKLKSQEKKIDYFERAKRLEEIP 711

Mouse   709 LIKSAYEEQRVKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYE 773
            |.:....|::|||.:.||..|:.||.....||:.|:..:.|:.||..|||.|:..||..|.|:|.
  Fly   712 LFEKYLAEKQVKDKEFWEATEKTRIENAIAERKDAVAQQERLKRMYPDRDEFLEALKKERASLYV 776

Mouse   774 EKLKQFEERLAEERHSRLEDRKRQRKEERKITYYREKEEEEQRRAEEQMLKEREERERAERAKRE 838
            ||||:||..|..||..||.||..:|:|||:..:.||||||..|:.||..|.:..|...|..|:|.
  Fly   777 EKLKKFEAALEAERKKRLADRIIRRREERRQAFLREKEEERLRKEEEIRLAQAAEERAAAEARRL 841

Mouse   839 EELREYQERVKKLEEVERKKRQRELEIEERERRREEER-RLGDDPLSRKDSRWGDRDSEGTWR-K 901
            |...|.::|..:.|    |:|.:|   ||.||:.:|:| ||..:..|.::....|||   ||| :
  Fly   842 EREAEDEKRRAQYE----KQRAKE---EEAERKIKEDRDRLSRELASERERTEKDRD---TWRPR 896

Mouse   902 G---PEA----DSEWRRGPPEKEWRRETRDDERPHRRDEDRLRRLGGDDEERESSLRPDDDRIPR 959
            |   |.|    .|||||..|... .|..|..||..|..| |:.| ||:..||      ..:||
  Fly   897 GGDRPSASNGGSSEWRRAAPAAS-ERNDRGGERIERGGE-RIER-GGERLER------GGERI-- 950

Mouse   960 RGLDDDRGPRRGPDEDRFSRRGTDDDRPSWRNADDDRPPRRIGDDDRGSWRHTDDDRPPRRGLDD 1024
                     .||.|.||....|.|.   |||...:....|.....|.|:.:..||
  Fly   951 ---------ERGGDRDRKDNEGADS---SWRVRREPDSQRAAAPKDSGAPQSRDD---------- 993

Mouse  1025 ERGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGMDDDRGPRRGLDDDRGP 1089
               .|         |||.:.||..|..||        ..|.|.||||..||  ||||..||:||.
  Fly   994 ---KW---------RRGGERDRDFRIDGA--------RRDRDDGPRRDRDD--GPRRDRDDERGG 1036

Mouse  1090 WRNAAEDRISRRGADDDRGPWRNMDDDRVPRRGDDARPGPWRPFVKPGGWREKEKAREESWGPPR 1154
            :                             ||.|.||                           |
  Fly  1037 F-----------------------------RRADGAR---------------------------R 1045

Mouse  1155 ESRPSEEREWDRDKEKDRDNQDREENDKDLERDRDRERDGDREDRFRRPRDEGGWRRGPAEESSS 1219
            ...|.                                            |:.||          :
  Fly  1046 TDEPQ--------------------------------------------RETGG----------N 1056

Mouse  1220 WRDSSRRDDRDREDRRRDRDDRRDLRDLRDRRDLRDDRDRRGPPLRSEREEASS------WRRTD 1278
            |||:.|.  .|||.||  ..:||| ||:|:.|.     |:||    |..:||:|      ||..
  Fly  1057 WRDAPRH--ADRETRR--PAERRD-RDVRETRG-----DQRG----SAPKEAASGGVGGNWRTA- 1106

Mouse  1279 DRKDDRTEERDPPRRVPPPALSRDREREREREGEKEKASWRAEKDRESLRRTKNETDEDG-WTTV 1342
                       |..|...||..||:.:|:|                       |:..:|| ||:|
  Fly  1107 -----------PATREEKPAAKRDQAQEKE-----------------------NKAGDDGEWTSV 1137

Mouse  1343 RR 1344
            :|
  Fly  1138 KR 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eif3a	NP_034253.3	PAM	426..498	CDD:214803	31/71 (44%)
		GBP_C	<566..685	CDD:303769	48/118 (41%)
		DUF342	<643..737	CDD:302792	46/93 (49%)
		coiled coil	650..661	CDD:293879	3/10 (30%)
		Interaction with EIF3B. /evidence=ECO:0000255\|HAMAP-Rule:MF_03000	664..835		84/170 (49%)
		coiled coil	674..685	CDD:293879	5/10 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..844		15/36 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..1240		97/382 (25%)
		Rubella_Capsid	882..1111	CDD:283420	70/236 (30%)
		21 X 10 AA approximate tandem repeats of [DA]-[DE]-[ED]-R-[PLIGFSV]-[RPS]-[RW]-[RL]-[GNIHT]- [DGLPTAM]	924..1133		57/208 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1252..1344		23/98 (23%)
eIF3a	NP_649470.2	PAM	429..>497	CDD:214803	28/67 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850478
Domainoid	1	1.000	439	1.000	Domainoid score	I553
eggNOG	1	0.900	-	-		E1_KOG2072
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2779
Inparanoid	1	1.050	921	1.000	Inparanoid score	I355
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54611
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003667
OrthoInspector	1	1.000	-	-		oto94578
orthoMCL	1	0.900	-	-		OOG6_102668
Panther	1	1.100	-	-	LDO	PTHR14005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R376
SonicParanoid	1	1.000	-	-		X3031
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790