DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Egr4 and cbt

DIOPT Version :9

Sequence 1:	NP_065621.1	Gene:	Egr4 / 13656	MGIID:	99252	Length:	478	Species:	Mus musculus
Sequence 2:	NP_722636.1	Gene:	cbt / 33224	FlyBaseID:	FBgn0043364	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	351	Identity:	91/351 - (25%)
Similarity:	131/351 - (37%)	Gaps:	89/351 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse   170 PQLSPPDVKPGLR------APPASPALD------------------AAASAFKGPYAPWELLSAG 210
            |:::.|:.||.|.      .||....||                  |.:|:.:      :..|:.
  Fly    66 PEIAVPNKKPRLEQPAMSMTPPPDQKLDDDQKAERVSVIMRVNSSGAVSSSSQ------DENSSS 124

Mouse   211 VPGNCGSQGSFQTTPEARFSAVGTKVEDLLSISCPAELPGPAARLYQAGAYDTFSLAPGDLGEGT 275
            ....|.|..:..|:.    |:|...|||        :.|       :|..:..............
  Fly   125 STSCCSSSSNTNTST----SSVPPTVED--------DYP-------EANVWRNLKFKMNRKRAAE 170

Mouse   276 EGLPALLTP--PGGEGGSGGEGGEFLAAPPAQ------------LSPLGLRGAATADFSKPLVAD 326
            ..||.:.||  |..:          |..|||.            |:|:.:...|::.....|:
  Fly   171 VALPPVQTPETPVAK----------LVTPPAPAECIKEEEIKPILTPIYVSPVASSASQLILL-- 223

Mouse   327 LPGGSGVAAPSSPAASFPAAKARRKGRRGGKCSARCFCPR---PHVKAFACPVESCVRSFARSDE 388
                |.|||..||.   |..|.......  |.:.|....:   ...:.:.|....|.:::.:|..
  Fly   224 ----STVAAQQSPT---PVPKTPTMSEE--KLTTRITAAQAAATRSRIYECSFPDCGKNYFKSSH 279

Mouse   389 LNRHLRIHTGHKPFQCR--ICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKV 451
            |..|.|:|||.:||.|:  .|.:.|||||.|:.|.|||||||.|.|.||.::|.|||...:|.|.
  Fly   280 LKAHQRVHTGERPFICKWENCDKRFSRSDELSRHKRTHTGEKKFQCSVCQKKFMRSDHLSKHVKR 344

Mouse   452 HLKQKARAEERLKGLGFYSLGLSFAA 477
            |.|.||....|...|...:...|.||
  Fly   345 HNKDKANGVNRHVSLANNNTSASVAA 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egr4	NP_065621.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..302		6/28 (21%)
		zf-C2H2	372..396	CDD:278523	6/23 (26%)
		C2H2 Zn finger	374..396	CDD:275368	6/21 (29%)
		zf-H2C2_2	388..413	CDD:290200	11/26 (42%)
		COG5048	400..>458	CDD:227381	31/59 (53%)
		C2H2 Zn finger	404..424	CDD:275368	10/21 (48%)
		zf-H2C2_2	416..441	CDD:290200	14/24 (58%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
cbt	NP_722636.1	zf-C2H2	263..287	CDD:278523	6/23 (26%)
		C2H2 Zn finger	265..287	CDD:275368	6/21 (29%)
		COG5048	<270..362	CDD:227381	42/91 (46%)
		zf-H2C2_2	279..306	CDD:290200	11/26 (42%)
		C2H2 Zn finger	295..317	CDD:275368	10/21 (48%)
		zf-H2C2_2	309..332	CDD:290200	13/22 (59%)
		zf-C2H2	323..345	CDD:278523	10/21 (48%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2698
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940