DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egfr and Egfr

DIOPT Version :9

Sequence 1:	NP_997538.1	Gene:	Egfr / 13649	MGIID:	95294	Length:	1210	Species:	Mus musculus
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1417	Identity:	500/1417 - (35%)
Similarity:	698/1417 - (49%)	Gaps:	341/1417 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    24 ALEEK--------KVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYV-QRNYDLSFL 79
            :||:|        |:|.||.:||:.....|.|:.:|:..|.||..|.||||:|:: ..|.|||||
  Fly    87 SLEDKNKNEFVKGKICIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFL 151

Mouse    80 KTIQEVAGYVLIALNTVERIPLENLQIIRGNALY-----ENTYALAILSNYGTNRTGLRELPMRN 139
            ..|:||.||:||:...|:::....||||||..|:     |..|||.:  .|....|  .|:|  :
  Fly   152 DNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFV--TYSKMYT--LEIP--D 210

Mouse   140 LQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGE 204
            |:::|.|.|.|.||..||:|.||||.:||.|...:..:.|..:....||||..||.:| |||.|.
  Fly   211 LRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG-CWGEGP 274

Mouse   205 ENCQKLTKIICAQQCS-HRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLM 268
            :||||.:|:.|:.||: .||.|..|.:|||..||.|||||.:.||:.|:.|.||..||:.|||:.
  Fly   275 KNCQKFSKLTCSPQCAGGRCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMR 339

Mouse   269 LYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPC 333
            .||||||.::.||||||::||||||:|| .:::.|:|:|||:|..|  ::::.|  :|..|:|||
  Fly   340 KYNPTTYVLETNPEGKYAYGATCVKECP-GHLLRDNGACVRSCPQD--KMDKGG--ECVPCNGPC 399

Mouse   334 RKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKG-----DSFTRTP---PLDPR 390
            .|.|.|:.:        ::|.||..|:.||.|.|::.||...|.|     .::|..|   ||||.
  Fly   400 PKTCPGVTV--------LHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPE 456

Mouse   391 ELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQF-SLAVVGLNITSLGLRSLK 454
            .||:..|||||||:|.|:.....:.:|..|.|||.|.||......| :||:|..::.||.:|:||
  Fly   457 RLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLK 521

Mouse   455 EISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPE 519
            :||.|.|:|..||:|||.:.|.|..:...|.||..:..|.....|:....:|:..|:.:||||..
  Fly   522 QISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADLCEKNGTICSDQCNEDGCWGAG 586

Mouse   520 PRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH 584
            ...|::|:|.:....|:..|..:....:  .:|..|..|||||.      ||.|.|.|:|.:|.|
  Fly   587 TDQCLTCKNFNFNGTCIADCGYISNAYK--FDNRTCKICHPECR------TCNGAGADHCQECVH 643

Mouse   585 YIDGPHCVKTCPA-----------------GIMGENNTL-------------------------- 606
            ..||.|||..||.                 |..|..:|:
  Fly   644 VRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINNDATVKRCLLKD 708

Mouse   607 -------VWKYADANN-----------VCHLCH----------------ANCTY----------- 626
                   .|:|.....           ||..||                :.||:
  Fly   709 DKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETEC 773

Mouse   627 ---------------------GCAGPGLQGC------------EVWP------------------ 640
                                 ||.|||...|            |..|
  Fly   774 PADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMR 838

Mouse   641 ---------------SGPKIPSIATGIVGGLLFIVVVAL---------GIGLFMRRRHIVRKRTL 681
                           |.|:...|...:...::||:..|:         .:....|::...:|.|:
  Fly   839 HVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETV 903

Mouse   682 R--RLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPV 744
            :  ..|...|..|||.||....|...|||:|:.|.:|..|||.||||.||||:|:||||.|||||
  Fly   904 KMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPV 968

Mouse   745 AIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKD 809
            |||||.::|..::::|.|.|||:||||::.::.:||.:|::|.:.|||||||.||||||||.::|
  Fly   969 AIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRD 1033

Mouse   810 NIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAE 874
            .|||:.||||..||||||:|||::||||||||||||||:||..||||||||||||.::..||.|.
  Fly  1034 KIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAA 1098

Mouse   875 GGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPP 939
            |||:||||:|||.|.:|::|.:||||::|||:|||:|||.:|::.|||.||..::|.|.:|.||.
  Fly  1099 GGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPE 1163

Mouse   940 ICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALM 1004
            ||::|:|..::.||.:||..||.|::|...|::.||||.|||.|.||:...||:.|.       .
  Fly  1164 ICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYTS-------Q 1221

Mouse  1005 DEEDM-----------EDVVDADEYLIPQQGFFNSPSTS-RTPLLSSLSATSNNSTVACINRNGS 1057
            ||:|:           |.:.:.|:||.|:.    :|..| ||.....:..
  Fly  1222 DEKDLIRKLAPTTDGSEAIAEPDDYLQPKA----APGPSHRTDCTDEIPK--------------- 1267

Mouse  1058 CRVKEDAFLQRYSSDPT---GAVTEDNIDDAF-----------LPVPEYVNQSVPKRPAGSVQNP 1108
                    |.||..||:   .:..:|..|.:.           |||.|                .
  Fly  1268 --------LNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDE----------------D 1308

Mouse  1109 VYHNQPLHPAPGRDLHYQNPHSN---AVG----------------NPEYLNTAQ---------PT 1145
            .|......|.|..:.:..||:.|   |||                |||||..||         ||
  Fly  1309 DYLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPIPT 1373

Mouse  1146 CLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEY 1197
               .....|.:.: .|:.::.:..|..:                ||:.:.||
  Fly  1374 ---QTIGIPVMGV-PGTMEVKVPMPGSE----------------PTSSDHEY 1405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egfr	NP_997538.1	Recep_L_domain	57..168	CDD:279382	51/116 (44%)
		Approximate	75..300		110/230 (48%)
		Furin-like	184..335	CDD:279142	77/151 (51%)
		FU	231..274	CDD:238021	24/42 (57%)
		Recep_L_domain	362..481	CDD:279382	54/127 (43%)
		Approximate	390..600		79/227 (35%)
		GF_recep_IV	505..636	CDD:291509	49/239 (21%)
		FU	506..559	CDD:238021	13/52 (25%)
		FU	552..598	CDD:214589	22/62 (35%)
		TM_ErbB1	634..679	CDD:213054	10/98 (10%)
		Important for dimerization, phosphorylation and activation. /evidence=ECO:0000250	690..706		6/15 (40%)
		PTKc_EGFR	706..1018	CDD:270683	177/322 (55%)
		TyrKc	715..970	CDD:197581	153/254 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1137		9/42 (21%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	56/136 (41%)
		GF_recep_IV	572..684	CDD:291509	39/172 (23%)
		FU	573..>606	CDD:238021	10/32 (31%)
		FU	617..659	CDD:214589	19/41 (46%)
		FU	662..716	CDD:214589	21/190 (11%)
		FU	739..786	CDD:238021	19/48 (40%)
		FU	784..834	CDD:214589	32/49 (65%)
		PTKc_EGFR_like	930..1208	CDD:270648	105/331 (32%)
		STYKc	938..1194	CDD:214568	91/281 (32%)
		Recep_L_domain	128..239	CDD:279382	49/116 (42%)
		Furin-like	253..401	CDD:279142	75/148 (51%)
		FU	255..292	CDD:214589	18/37 (49%)
		FU	302..345	CDD:238021	23/42 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1078
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45861
OrthoDB	1	1.010	-	-		D51516at33208
OrthoFinder	1	1.000	-	-		FOG0000755
OrthoInspector	1	1.000	-	-		otm42670
orthoMCL	1	0.900	-	-		OOG6_101159
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5222
SonicParanoid	1	1.000	-	-		X448
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.820