DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egf and arr

DIOPT Version :9

Sequence 1:	XP_011238312.1	Gene:	Egf / 13645	MGIID:	95290	Length:	1221	Species:	Mus musculus
Sequence 2:	NP_524737.2	Gene:	arr / 44279	FlyBaseID:	FBgn0000119	Length:	1678	Species:	Drosophila melanogaster

Alignment Length:	1244	Identity:	292/1244 - (23%)
Similarity:	452/1244 - (36%)	Gaps:	352/1244 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 W--LLLAFLLVFLKISILSVTAWQTGNCQPGPLERSERSGTCAGP--APF------LVFS----- 58
            |  :|:.|||:...||    .:||..|     :.....|...|.|  :.|      |:|:
  Fly    42 WRQMLIGFLLICFGIS----NSWQYKN-----VHMPSSSSLIASPPASAFVNTPATLLFTTRHDI 97

Mouse    59 QGKSISRIDPDGTNHQQLVV-DAGISADMDIHYKKERLYWVDVERQVLLRVFLNGTGLEKVCNVE 122
            |..:|:|  |.|.....::| |...:..:|.:|.|..:.|.|..|:::.....|.:.|:.:....
  Fly    98 QVANITR--PTGGPQIDVIVRDLAEAMAIDFYYAKNLVCWTDSGREIIECAQTNSSALQPLLRAP 160

Mouse   123 R---------KVSGLAIDWIDDEVLWVDQQNGVITVTDMTGKNSRVLL-SSLKHPSNIAVDPIER 177
            :         |..|||:||..|::.|.|.:...|.|..:.|:..:||. :.|..|..:||.|..:
  Fly   161 KQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNRIEVATLDGRYQKVLFWTDLDQPRAVAVVPARK 225

Mouse   178 LMFWS--SEVTGSLHRAHLKG--VDVKTLLE-----TGGISVLTLDVLDKRLFWVQDSGEGSHAY 233
            |:.|:  .|.. .:.||.:.|  :...||::     ..|::|   |:.::.::|.    :|.|.:
  Fly   226 LLIWTDWGEYP-KIERASMDGDPLSRMTLVKEHVFWPNGLAV---DLKNELIYWT----DGKHHF 282

Mouse   234 IHSCDYEGGSVRLIRHQARHSLSSMAFFGDRIFYSVLKSKAIWIANKHTGKDTVRINLHPSFVTP 298
            |.....:|.|.|.|.:..::.. |:.|:.||::::                |..|.:|:
  Fly   283 IDVMRLDGSSRRTIVNNLKYPF-SLTFYDDRLYWT----------------DWQRGSLN------ 324

Mouse   299 GKLMVVHPRAQPRTEDAAKDPG--ESLDPELLKQRGRPCRFGLCERDPKSHSSACAEGYTLSRDR 361
              .:.:..|......|..|.|.  .:.||.|......||          :|::
  Fly   325 --ALDLQTRELKELIDTPKAPNSVRAWDPSLQPYEDNPC----------AHNN------------ 365

Mouse   362 KYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQCHELVSCPGNVSKCSHGCVL-- 424
                                                               ||   |||.|:|
  Fly   366 ---------------------------------------------------GN---CSHLCLLAT 376

Mouse   425 TSDGPRCICPAGSVLGRDGKTCTGCSSPDNGGCSQICLPLRPGSWECDCFPGYDLQSDRKSCAAS 489
            .|.|..|.||.|..| ....||                                         |:
  Fly   377 NSQGFSCACPTGVKL-ISANTC-----------------------------------------AN 399

Mouse   490 GPQPLLLFANSQDIRHMHFDGTDYKVLLSRQMGMV---FALDYDPVESKIYFAQTALKWIERANM 551
            |.|.::.......|..:..|..|| .:....:|.|   .|:||||||..||::......|:||:.
  Fly   400 GSQEMMFIVQRTQISKISLDSPDY-TIFPLPLGKVKYAIAIDYDPVEEHIYWSDVETYTIKRAHA 463

Mouse   552 DGSQRERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHHRIIIQERISRPRGIAVH 616
            ||:.....:|..|...:||||||:.|.:||||:....:....|.|...:::|.|.:..||.|||.
  Fly   464 DGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRLDGTARKVLIYEHLEEPRAIAVA 528

Mouse   617 PRARRLFWTDVG-MSPRIESASLQGSDRVLIASSNLLEPSGITIDYLTDTLYWCDTKRSVIEMAN 680
            |....:||:|.. ..|::|.|||.||:||::.|.||..|:||.:|.....:||||.|...||:||
  Fly   529 PSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIALDIEAKAIYWCDGKTDKIEVAN 593

Mouse   681 LDGSKRRRLIQNDVGHPFSLAVFEDHLWVSDWAIPSVIRVNKRTGQNRV-------RLQGSMLKP 738
            :|||.||.:|.:::.|.|.|::.:|:|:.:||...|:.|.:|.||.||:       .|.|  ||.
  Fly   594 MDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKITGNNRIVVVDQYPDLMG--LKV 656

Mouse   739 SSLVVVHPLAKPGADPCLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC-LPQDYPILSGEN 802
            :.|..|.     |.:.|..|||||.|:|........|.|...:..|.|.:.| :|..:.:.|.:.
  Fly   657 TRLREVR-----GQNACAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKRTCVVPAAFLLFSRQE 716

Mouse   803 --ADLSKEVTSLSNSTQAEVPDDDGTESSTL---VAEIMVSGMNYEDDC---------------- 846
              ..:|.|... .|.....:|..|..::..|   |||..:...:.:..|
  Fly   717 HIGRISIEYNE-GNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCIFRAFLNGSYVQRIVD 780

Mouse   847 ----GPGGCG------------SHARCVS----DGETAECQCLKGFARDGNLCSDIDECVLARSD 891
                ||.|..            :.||.:.    ||.:......||.....:|..:.....:..::
  Fly   781 SGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPRSLVLEPRRGYMYWTE 845

Mouse   892 CPSTSSRCINTEGGYVCRCSEGYEGDGISCFDIDECQRGAHNCGENAACTNTEGGYNCTCAGRPS 956
            .|:.|.|....:|.                 |:.....||::.........|...|..| ..||:
  Fly   846 SPTDSIRRAAMDGS-----------------DLQTIVAGANHAAGLTFDQETRRLYWAT-QSRPA 892

Mouse   957 SPGLSCPDSTAPSLL-GEDGHHLDRNSYPGCPSSYDGYCLNGGVCMHIESLDSYTCNCVIGYSGD 1020
            ....:..|.....:| |.|   :|.   |...|.|..|.                      |..|
  Fly   893 KIESADWDGKKRQILVGSD---MDE---PYAVSLYQDYV----------------------YWSD 929

Mouse  1021 RCQTRDLRWWELRHAGYGQKHDIMVVAVCMVALVLLLVLGMWGTYYYRTRKQLSNPPKNPCDEPS 1085
             ..|.|:   |..|...||...:  |...|..:..|||        :..::|..   .|||...:
  Fly   930 -WNTGDI---ERVHKTTGQNRSL--VHSGMTYITSLLV--------FNDKRQTG---VNPCKVNN 977

Mouse  1086 GSVS-----SSGPNSSSGAAV---------ASC--PQPWFV---------VLEKHQDPKNGSLPA 1125
            |..|     ..|....:.|..         .||  |:.:.:         :|....|..|..||.
  Fly   978 GGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIPPRNYIIFSQRNCFGRLLPNTTDCPNIPLPV 1042

Mouse  1126 DGTNGAVVD 1134
            .|.|...||
  Fly  1043 SGKNIRAVD 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egf	XP_011238312.1	LY	<86..114	CDD:214531	7/27 (26%)
		LY	<125..156	CDD:214531	11/30 (37%)
		LY	158..199	CDD:214531	13/45 (29%)
		FXa_inhibition	370..405	CDD:373209	0/34 (0%)
		FXa_inhibition	418..446	CDD:373209	12/29 (41%)
		FXa_inhibition	453..486	CDD:373209	0/32 (0%)
		LY	514..556	CDD:214531	16/44 (36%)
		LY	557..599	CDD:214531	15/41 (37%)
		LY	600..643	CDD:214531	18/43 (42%)
		LY	643..686	CDD:214531	21/42 (50%)
		LY	687..728	CDD:214531	14/40 (35%)
		FXa_inhibition	755..790	CDD:373209	12/34 (35%)
		EGF_CA	881..921	CDD:311536	4/39 (10%)
		EGF_CA	923..>951	CDD:311536	5/27 (19%)
		PHA02887	<986..1023	CDD:165214	5/36 (14%)
arr	NP_524737.2	LY	162..201	CDD:214531	11/38 (29%)
		NHL	168..503	CDD:302697	107/486 (22%)
		NHL repeat	172..237	CDD:271320	21/65 (32%)
		LY	252..293	CDD:214531	10/47 (21%)
		NHL repeat	261..298	CDD:271320	11/43 (26%)
		NHL repeat	303..339	CDD:271320	8/60 (13%)
		NHL repeat	341..419	CDD:271320	28/195 (14%)
		NHL repeat	428..476	CDD:271320	17/47 (36%)
		LY	472..511	CDD:214531	15/38 (39%)
		NHL repeat	477..503	CDD:271320	11/25 (44%)
		Ldl_recept_b	534..573	CDD:278487	18/38 (47%)
		LY	558..599	CDD:214531	19/40 (48%)
		LY	600..641	CDD:214531	14/40 (35%)
		FXa_inhibition	668..703	CDD:291342	12/34 (35%)
		LY	739..773	CDD:214531	6/33 (18%)
		LY	776..818	CDD:214531	7/41 (17%)
		LY	819..860	CDD:214531	7/57 (12%)
		FXa_inhibition	973..1010	CDD:291342	5/36 (14%)
		LY	1122..1164	CDD:214531
		FXa_inhibition	1273..1313	CDD:291342
		LDLa	1319..1362	CDD:238060
		LDLa	1365..1399	CDD:238060
		LDLa	1399..1433	CDD:197566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810