DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ect2 and pbl

DIOPT Version :9

Sequence 1:NP_031926.2 Gene:Ect2 / 13605 MGIID:95281 Length:913 Species:Mus musculus
Sequence 2:NP_523965.2 Gene:pbl / 38879 FlyBaseID:FBgn0003041 Length:1311 Species:Drosophila melanogaster


Alignment Length:1319 Identity:320/1319 - (24%)
Similarity:484/1319 - (36%) Gaps:535/1319 - (40%)


- Green bases have known domain annotations that are detailed below.


Mouse    75 MEVPVIKIKESCPGKSEEKLIKSIINMEMKVPCV-----KMDSMEEFESL--------------- 119
            ||:..|:.:..|.        .||..:..::..|     ..|:::..||.               
  Fly     1 MEMETIEEQSKCE--------MSITTLPTRICLVGGVGQDADTLQAAESFGLPIVTSDTGLDILG 57

Mouse   120 DSPEFENIFVVTDFQNSVFNDLYKADCRIVGPPVILNCAQRGEPLPFSCRPLYCTSMLNLVLCFT 184
            :|.::...:|:.||:.:.|..::|....|:|||.:...|:..:.|..:.||:|..:|..:|.|||
  Fly    58 ESSDWRTFYVLDDFEGASFEAIHKQKECILGPPALKYAAEMKQTLGQNSRPIYNYAMRGVVTCFT 122

Mouse   185 GFRKKEELVKLVTLVHHMGGVIRKECNSKVTHLVANCTQGEKFRVAVSLGTPIMKPEWIYKAWER 249
            |.|||:||.|||.|:|.|||.|:|:.|:|.|||:.|.:.|||::.|.:....:::|.|::.||..
  Fly   123 GIRKKDELTKLVNLIHSMGGCIKKDLNTKTTHLICNHSGGEKYQYAKTFRLTVVRPAWVFAAWAD 187

Mouse   250 RNEQCFCAAVDDFRNEFKVPPFQDCILSFLGFSDEEKHSMEEMTEMQGGSYLPVGDERCTHLI-- 312
            ||...|.|..::|....::..|:...:.|.||..||...|.::....||....:.|..|:|::  
  Fly   188 RNSLEFDATQENFTKTHRLKAFEGQKICFFGFPVEEHQHMVDVLLENGGVCAELDDPECSHVVMP 252

Mouse   313 ----------------------------------------------------------------- 312
                                                                             
  Fly   253 NTGAVFTSTSTSTDTNPSTLINPPESQVPGSSSASQAGEEEQRKAEHLEQAEIKKMEYSHAETDN 317

Mouse   313 ----------------------------------------------------------------- 312
                                                                             
  Fly   318 GMSLDIDQEQKENQGIEDEDDIHFDERLFVEAADIINHGEDQLPESDEEDLEEEQKPKVEEVLKE 382

Mouse   313 --VEENT----------------------------------------------------VKDLP- 322
              |||:.                                                    ..||| 
  Fly   383 QEVEEDVQASTPKTSKIRTSLKAATPLSSPEMDGIALDFESTTQNISPILKAIDECDLETDDLPP 447

Mouse   323 ---------------------------------------------------FEP----------- 325
                                                               .||           
  Fly   448 SENDLKRKRESFDNVSLMSVDSFALPASTKKPKLIRTGSISRTLRRSVSFVAEPLMKTLRPRRSS 512

Mouse   326 ----------------------------------------------------------------- 325
                                                                             
  Fly   513 VADASSFVGSEAADNSICSLASSINLTLNDSIRKPVKEKLRSFCGRITRSSSRRHDRGVDGTPEC 577

Mouse   326 ------------------------SKKLF------------------------------------ 330
                                    :|:||                                    
  Fly   578 TTLLDSGFKTPKAPKLRSTATPKTAKRLFGPVSGVVSALTLTNPSTPTPNPNPNTNCTATLDVND 642

Mouse   331 ----------------------------------------------------------------- 330
                                                                             
  Fly   643 TSIHTFAFCAAAVTPAMPPSSSSSSSSPILSTSIAVHSSVQVIKSPEESTTRRNSPAPIEEPMAM 707

Mouse   331 -------------------VVKQEWFWGSIQ------MDARAGETMYLYEKANTPELKKSVSL-L 369
                               ::|.:|||.:||      ||...|:  ||....|||...:..|| :
  Fly   708 VVDEHTTLTKPEPKNNHTHILKSDWFWYTIQNGYANEMDYLFGD--YLDSITNTPNTDRRDSLPI 770

Mouse   370 SLSTPNSNRKRRRLKETLAQLSRETDLSPFPPRKRPSAEHSLSIGSLLDISN-------TPESSI 427
            |.    :.|||:|..:.:     :.:.:|....||.|   |:|...||.:||       :|:.. 
  Fly   771 SF----NKRKRKRFSQRI-----QLEGTPLGSGKRRS---SVSDAGLLSVSNSLFDCTTSPDKL- 822

Mouse   428 HYGETPKSCAKSSRSSTPVPPKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPI 492
               |:.|.......:|...|.|:|.|:....:.|.||||||.||.||:.||:..|||..:...|:
  Fly   823 ---ESDKLLHAEPEASDATPAKKSMRFNHFMDFYTTESNYVGILDTILNLFKNKLEELAETNDPL 884

Mouse   493 LAPEEIKTIFGSIPDIFDVHMKIKDDLEDLIANWDESRSIGDIFLKYAKDLVKTYPPFVNFFEMS 557
            |...|||||||:...|.:||..:.:.|..|.|||.|...||||.:::..:|:|.|||:|||||..
  Fly   885 LNKSEIKTIFGNFLPIHEVHQSMLEHLRKLHANWREDCLIGDIIIQHRDELIKAYPPYVNFFEQM 949

Mouse   558 KEMIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKS 622
            ||.:..|:::.|||||||||||.|||||||.|.:|:|||||||||::|||||:.|||...|.|..
  Fly   950 KEQLQYCDREYPRFHAFLKINQTKPECGRQGLQDLMIRPVQRLPSISLLLNDILKHTTSGNADHG 1014

Mouse   623 TLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSSHRSLVQRVETVSLGEHPCD 687
            .||:|:.::|:|..|||||||:||::..|||:..:::||||:|:||:||.:.:.|...|.:....
  Fly  1015 RLEEALKAIKQVTLHINEDKRRTESRMAIFDIFNDIEGCPAHLVSSNRSFILKCEVNELSDSLSG 1079

Mouse   688 RGEQVTLFLFNDCLEIARKRHKVIGTFRSPHD-RTRPPASLKHIHLMPLSQIKKVLDIRETEDCH 751
            ||:.:.|:||:|.:|:.::|.|...|.:||.. :|.     ||:.|:.|:.|:.|:||   .|..
  Fly  1080 RGDSLVLYLFSDSIELCKRRSKGFNTAKSPSTAKTH-----KHLKLISLNTIRLVIDI---SDSP 1136

Mouse   752 NAFALLVRPPTEQANVLLSFQMTSEELPKESWLKMLCRHVANTICKADAENLMYVADPESFEVNT 816
            .||.||:|...|:   |.:|.::.||..|..::|.||..:|...|:.||:.|:.....:..||:.
  Fly  1137 RAFGLLLRGDKEK---LYTFTISDEETDKSVYVKKLCNQIAAHTCRTDADKLLICRTSQELEVDI 1198

Mouse   817 KDMD-STLSRASRAIKKTSKKVTRAFSFSKTP---KRALRMALSSSHSSEGRSPPSSGKLAVSRL 877
            .|:: ||||:|.:...||..||.|||||:|||   |||:...::|...|.....|:| :||..||
  Fly  1199 SDVNVSTLSKAFKLAAKTRLKVGRAFSFNKTPNKLKRAVSTMMTSPFGSTNSLTPAS-QLAQMRL 1262

Mouse   878 SSTSSLAGIPSPSLVSLPS 896
            :|.:::..:......|:.|
  Fly  1263 ASCTNINEVDDEDCASMRS 1281

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ect2NP_031926.2 PRK09630 <71..>125 CDD:170022 11/69 (16%)
BRCT_Ect2_rpt1 176..251 CDD:349365 35/74 (47%)
BRCT_Ect2_rpt2 270..349 CDD:349364 31/542 (6%)
RhoGEF 456..640 CDD:214619 97/183 (53%)
PH_Ect2 631..804 CDD:269936 65/173 (38%)
pblNP_523965.2 PTCB-BRCT 117..180 CDD:289507 31/62 (50%)
RhoGEF 852..1032 CDD:279015 97/179 (54%)
PH_Ect2 1023..1186 CDD:269936 65/173 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841030
Domainoid 1 1.000 203 1.000 Domainoid score I2967
eggNOG 1 0.900 - - E1_KOG3524
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7298
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5713
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007255
OrthoInspector 1 1.000 - - oto92170
orthoMCL 1 0.900 - - OOG6_104055
Panther 1 1.100 - - LDO PTHR16777
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3920
SonicParanoid 1 1.000 - - X5358
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.680

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