back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CPB1 and CG8945

DIOPT Version :9

Sequence 1:	NP_001862.2	Gene:	CPB1 / 1360	HGNCID:	2299	Length:	417	Species:	Homo sapiens
Sequence 2:	NP_573190.1	Gene:	CG8945 / 32693	FlyBaseID:	FBgn0030815	Length:	1430	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	117/468 - (25%)
Similarity:	207/468 - (44%)	Gaps:	95/468 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    22 FEGEKVFRVNVEDENHINIIREL---ASTTQIDFWKPDSV-----TQIKPHSTVDFRVKAEDTVT 78
            ::..:::|:..:||..:..:.|.   ....::.:.|..|:     ..:.|...|||
  Fly   981 YDKYQIWRLKPQDEEQVRALEEFKKGEDGVKLQWLKGPSLRGLTDVLVPPKMLVDF--------- 1036

Human    79 VENVLKQNELQYKVLISNLRNVVEAQF----------DSRVRATG---HSYEKYNKWETIEAWTQ 130
             :..|....:.::|||.::...:..:.          .|:.|.|.   .::.:|:..:.|..:.:
  Fly  1037 -QGTLNYEGIAHEVLIFDVGKAIAYELTKEDYLQTTRPSKPRPTAPPPMTWNRYHNHDEIVKYLE 1100

Human   131 QVATENPALISRSVIGTTFEGRAIYLLKV-----------------------GKAGQNKPAIFMD 172
            .|...:|.|:....||.:||||.:.::|:                       .|:||.. |:|::
  Fly  1101 TVRMRHPQLVELIHIGRSFEGRPLIVVKIESKQTAAAANNDGLHTIKRPKRKRKSGQAN-AVFVE 1164

Human   173 CGFHAREWISPAFCQWFVREAVRTY--GREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRK 235
            .|.....||.||...|.:.|.:|..  .:..:..|.:....:|::||||.|||.|:....|||:|
  Fly  1165 AGAQGLAWIGPAAATWMIAELLRLMKTNKSNEDVEFIRNTTWYIMPVLNPDGYAYSHEYDRFWKK 1229

Human   236 TRSTH---------------------TGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAES 279
            :||.|                     ....|.|.|.:||:...|.:.|:|:.||:|.|.|||..|
  Fly  1230 SRSQHQTPPPSGLLDSAMTWLQQKRGPDKVCYGVDLDRNWLYHWGKRGSSKAPCNEFYAGPAPFS 1294

Human   280 EKETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASL--- 341
            |.||||:::|:.:..:.||.|:::.:|.|::.||.       :.|:..|:.......::|.:
  Fly  1295 EPETKAVSEFLMDYRTQIKLYISLQAYGQVISYPV-------KANSTFNSERLDDFLDVAMVGTD 1352

Human   342 ----HGTKYTYGPGATT--IYPAAGGSDDW-AYDQGIRYSFTFELRDTGRYGFLLPESQIRATCE 399
                .|:|..|...|:.  |...:|.:|.: ||:.||.:|:|.:|.|.|.:|:|||.|.|..|..
  Fly  1353 GLRKKGSKSRYKVDASNDLIEQRSGCADAFAAYEIGIPFSYTLQLADNGVHGYLLPSSAIEPTAR 1417

Human   400 ETFLAIKYVASYV 412
            :.|..|..:..|:
  Fly  1418 DAFEIISGMLDYI 1430

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.