Protein Alignment ADORA2B and AdoR

DIOPT Version :10

• Sequence 1: NP_000667.1
• Gene: ADORA2B / 136
• HGNCID: 264
• Length: 332
• Species: Homo sapiens
• Sequence 2: NP_651772.1
• Gene: AdoR / 43583
• FlyBaseID: FBgn0039747
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 369
• Identity: 114/369 - (30%)
• Similarity: 178/369 - (48%)
• Gaps: 67/369 - (18%)

Human    10 YVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTD 74
            |...|:::|.:|:.|||||.........|:..|||::||||.||:.||...|||||..|:|...:
  Fly    44 YTVFEVLVAIVSIIGNVLVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRN 108

Human    75 FYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLT 139
            .:.|||....::||...|||.|:||:||||.||..|:.|...|....|..:|::.||....:|..
  Fly   109 LHACLFTVSLLVVLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFL 173

Human   140 PFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIK 204
            |..||::            |...|:     :|||..|:..:|:| |.:|..::.|.|:||..|..
  Fly   174 PLFGWHA------------DVNHNQ-----ECLFVEVMDYNYLV-FLYFATIITPALLMLAFYTH 220

Human   205 IFLVACRQLQRTELMD-----------------------HSRTTL-------QREIHAAKSLAMI 239
            |:.|..:|:::...|:                       |:.|.|       :|::.|.::|::|
  Fly   221 IYRVIIKQVRQIVTMNPASDLSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSII 285

Human   240 VGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKI 304
            |..|.:||:|::.:||:..|.| .....||..: ..|:|||.||.|||::|||..:|||.....:
  Fly   286 VLFFMICWIPLYTINCIKAFCP-DCYVHPKLTL-FCIILSHLNSAVNPVLYAYHLKDFRAALKNL 348

Human   305 ISRYLLCQADVKS-----------------GNGQAGVQPALGVG 331
            :.:.:....|.::                 .:.....||.|.||
  Fly   349 LLKMMGVDIDQQAEAIHRFSVASQHRLQSMDSNMRSTQPRLYVG 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADORA2B	NP_000667.1	7tmA_Adenosine_R_A2B	8..301	CDD:320197	108/320 (34%)
		TM helix 1	9..35	CDD:320197	9/24 (38%)
		TM helix 2	42..69	CDD:320197	16/26 (62%)
		TM helix 3	78..108	CDD:320197	16/29 (55%)
		TM helix 4	122..140	CDD:320197	5/17 (29%)
		TM helix 5	179..209	CDD:320197	10/29 (34%)
		TM helix 6	227..257	CDD:320197	11/29 (38%)
		TM helix 7	269..294	CDD:320197	13/24 (54%)
AdoR	NP_651772.1	7tmA_Adenosine_R	42..345	CDD:341316	108/320 (34%)
		TM helix 1	43..69	CDD:341316	9/24 (38%)
		TM helix 2	76..103	CDD:341316	16/26 (62%)
		TM helix 3	112..142	CDD:341316	16/29 (55%)
		TM helix 4	156..174	CDD:341316	5/17 (29%)
		TM helix 5	196..225	CDD:341316	10/29 (34%)
		TM helix 6	273..303	CDD:341316	11/29 (38%)
		TM helix 7	313..338	CDD:341316	14/25 (56%)