Protein Alignment ADORA2B and TyrR

DIOPT Version :10

• Sequence 1: NP_000667.1
• Gene: ADORA2B / 136
• HGNCID: 264
• Length: 332
• Species: Homo sapiens
• Sequence 2: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 108/535 - (20%)
• Similarity: 169/535 - (31%)
• Gaps: 244/535 - (45%)

Human     1 MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAI 65
            ::|..|..:.:|:......::|.||.||..|:.|...|:|.||.|::|||.||:.||:|.:|.|:
  Fly   110 LVLSWQGIILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAV 174

Human    66 TI------SLGF--CTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTR- 121
            .:      .||:  |.     ::::..||:.| :||.||.|::||||||:..||.|.......|
  Fly   175 AVHLIGSWQLGWVLCD-----IWISLDVLLCT-ASILSLCAISVDRYLAVTRPLTYSRKRRSKRL 233

Human   122 ARGVIAVLWVLAFGIGLTPFLGW------NSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS 180
            |..:|.::|:||..|...|.|||      :.::...|.         ||...:...:....:||:
  Fly   234 ALIMILIVWLLALAITCPPMLGWYEPGRRDLRECRYNQ---------NEGYVIFSAMGSFFIPMA 289

Human   181 YMVY-FNFFGCVLPPL---LIMLVIYIKIF-------------------LVACRQLQRT------ 216
            .|:| :....||:...   :..:.::.|.|                   .|..||.|.|
  Fly   290 VMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQATSRTFSN 354

Human   217 -----ELMD-------------------------------------------------------- 220
                 ||.|
  Fly   355 QTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCY 419

Human   221 --------------------------------------------------------------HSR 223
                                                                          ||.
  Fly   420 ELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSH 484

Human   224 ---------------------------------------------TTLQREIHAAKSLAMIVGIF 243
                                                         |:|::|....::|:::||.|
  Fly   485 GERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLSIVVGGF 549

Human   244 ALCWLPVHAVNCVTLF----QPAQGKNKP-KWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHK 303
            ..||||......:|.|    |.:|...|. .|       |...||.:||.:||:.:.|||..|.:
  Fly   550 IACWLPFFINYLITPFLAEHQASQMLAKALTW-------LGWFNSAINPFIYAFYSVDFRAAFWR 607

Human   304 IISRYLLCQADVKSG 318
                 |.|:....:|
  Fly   608 -----LTCKRFFSAG 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADORA2B	NP_000667.1	7tmA_Adenosine_R_A2B	8..301	CDD:320197	102/509 (20%)
		TM helix 1	9..35	CDD:320197	7/25 (28%)
		TM helix 2	42..69	CDD:320197	13/32 (41%)
		TM helix 3	78..108	CDD:320197	14/29 (48%)
		TM helix 4	122..140	CDD:320197	6/17 (35%)
		TM helix 5	179..209	CDD:320197	7/52 (13%)
		TM helix 6	227..257	CDD:320197	9/29 (31%)
		TM helix 7	269..294	CDD:320197	8/24 (33%)
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	63/200 (32%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	13/25 (52%)
		TM helix 3	189..219	CDD:320189	15/35 (43%)
		TM helix 4	232..255	CDD:320189	8/22 (36%)
		TM helix 5	272..297	CDD:320189	6/24 (25%)
		7tm_GPCRs	<533..605	CDD:475119	25/78 (32%)
		TM helix 6	539..561	CDD:320189	8/21 (38%)
		TM helix 7	573..598	CDD:320189	10/31 (32%)