Protein Alignment ADORA2B and Dop2R

DIOPT Version :10

• Sequence 1: NP_000667.1
• Gene: ADORA2B / 136
• HGNCID: 264
• Length: 332
• Species: Homo sapiens
• Sequence 2: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Alignment Length: 560
• Identity: 109/560 - (19%)
• Similarity: 163/560 - (29%)
• Gaps: 284/560 - (50%)

Human     3 LETQDALYVALELVI-AALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAIT 66
            |...|..|.||.|:: ..|::.||:||..:|....:|||.||||:||||.||:.|.:..:|||:.
  Fly   370 LRVVDHNYWALILILFPILTLFGNILVILSVCRERSLQTVTNYFIVSLAIADLLVAVVVMPFAVY 434

Human    67 ISLG--------FCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRAR 123
            ..:.        .| |||..:.:.|     :.||||:|:|:::|||:|:..|::|.......|..
  Fly   435 FLVNGAWALPDVVC-DFYIAMDVIC-----STSSIFNLVAISIDRYIAVTQPIKYAKHKNSRRVC 493

Human   124 GVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFF 188
            ..|.::|.::..||....||.|:    |.| .||           ..|.|.|...:.|....:|:
  Fly   494 LTILLVWAISAAIGSPIVLGLNN----TPN-REP-----------DVCAFYNADFILYSSLSSFY 542

Human   189 GCVLPPLLIMLVIYIKIF-----------------------------LVACRQLQRTELMDHSR- 223
                .|.:||:.:|..||                             :...|:|..|.| |.||
  Fly   543 ----IPCIIMVFLYWNIFKALRSRARKQRAARKPHLSELTGGSVIENIAQTRRLAETAL-DSSRH 602

Human   224 ----------------------------------------------------------------- 223
                                                                             
  Fly   603 ASRILPDEAATNTASGSNEEEDENAISPDIDDCHVIVNDKSTEFMLATVVEETGNSVVAQITTQP 667

Human   224 ------------------------------------------------------TTLQR------ 228
                                                                  .||||
  Fly   668 QLVVADPNGNHDSGYAASNVDDVLAGVAPASASAATSAAPRSSGSPPDSPLPSGATLQRSSVSSQ 732

Human   229 ----------------------------------------------------------------- 228
                                                                             
  Fly   733 RRPTGDDSPKRGEPALRSVGVDNSSVAMKPLSFVRYGVQEAMTLARNDSTLSTTSKTSSRKDKKN 797

Human   229 ---------EIH-----------------AAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKN- 266
                     ::|                 |.|:||:::|:|..||||..:.|.:........|:
  Fly   798 SQASRFTIYKVHKASKKKREKSSAKKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDC 862

Human   267 KP-KWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKII 305
            :| ..|..|...|.:.||.|||::|...|.:||..|.||:
  Fly   863 RPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADORA2B	NP_000667.1	7tmA_Adenosine_R_A2B	8..301	CDD:320197	104/549 (19%)
		TM helix 1	9..35	CDD:320197	10/26 (38%)
		TM helix 2	42..69	CDD:320197	14/26 (54%)
		TM helix 3	78..108	CDD:320197	11/29 (38%)
		TM helix 4	122..140	CDD:320197	4/17 (24%)
		TM helix 5	179..209	CDD:320197	8/58 (14%)
		TM helix 6	227..257	CDD:320197	14/126 (11%)
		TM helix 7	269..294	CDD:320197	9/24 (38%)
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	67/214 (31%)
		TM helix 1	377..403	CDD:320181	10/25 (40%)
		TM helix 2	410..436	CDD:320181	14/25 (56%)
		TM helix 3	448..478	CDD:320181	15/35 (43%)
		TM helix 4	490..513	CDD:320181	5/22 (23%)
		TM helix 5	529..558	CDD:320181	9/32 (28%)
		7tm_GPCRs	<822..898	CDD:475119	25/75 (33%)
		TM helix 6	828..850	CDD:320181	9/21 (43%)
		TM helix 7	866..891	CDD:320181	9/24 (38%)