Protein Alignment ADORA2B and Adora2b

DIOPT Version :10

• Sequence 1: NP_000667.1
• Gene: ADORA2B / 136
• HGNCID: 264
• Length: 332
• Species: Homo sapiens
• Sequence 2: NP_058857.2
• Gene: Adora2b / 29316
• RGDID: 2050
• Length: 332
• Species: Rattus norvegicus
• Alignment Length: 332
• Identity: 285/332 - (85%)
• Similarity: 306/332 - (92%)
• Gaps: 0/332 - (0%)

Human     1 MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAI 65
            |.||||||||||||||||||:||||||||||||.::.|||||||||||||.||||||||||||||
  Rat     1 MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAI 65

Human    66 TISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLW 130
            ||||||||||:.||||||||||||||||||||||||||||||.||||||.|||||||||:|||||
  Rat    66 TISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLW 130

Human   131 VLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPL 195
            ||||||||||||||||||.||:|||||.||.||:|||.|||||||||||||||||||||||||||
  Rat   131 VLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVLPPL 195

Human   196 LIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQ 260
            |||:|||||||:|||:|||..|||:||||||||||||||||||||||||||||||||:||:|||.
  Rat   196 LIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFH 260

Human   261 PAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQ 325
            ||..|:||||.||:|||||||||||||:|||||||||||:||:|||||:|||.|.|.|:||||.|
  Rat   261 PALAKDKPKWVMNVAILLSHANSVVNPVVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGQAGGQ 325

Human   326 PALGVGL 332
            ....:.|
  Rat   326 STFSLSL 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADORA2B	NP_000667.1	7tmA_Adenosine_R_A2B	8..301	CDD:320197	260/292 (89%)
		TM helix 1	9..35	CDD:320197	24/25 (96%)
		TM helix 2	42..69	CDD:320197	25/26 (96%)
		TM helix 3	78..108	CDD:320197	29/29 (100%)
		TM helix 4	122..140	CDD:320197	16/17 (94%)
		TM helix 5	179..209	CDD:320197	27/29 (93%)
		TM helix 6	227..257	CDD:320197	28/29 (97%)
		TM helix 7	269..294	CDD:320197	21/24 (88%)
Adora2b	NP_058857.2	7tm_GPCRs	8..301	CDD:475119	260/292 (89%)
		TM helix 1	10..34	CDD:410628	22/23 (96%)
		TM helix 2	43..65	CDD:410628	20/21 (95%)
		TM helix 3	79..101	CDD:410628	21/21 (100%)
		TM helix 4	124..140	CDD:410628	14/15 (93%)
		TM helix 5	180..203	CDD:410628	21/22 (95%)
		TM helix 6	233..255	CDD:410628	20/21 (95%)
		TM helix 7	269..294	CDD:410628	21/24 (88%)