DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADORA2B and Adora2b

DIOPT Version :9

Sequence 1:	NP_000667.1	Gene:	ADORA2B / 136	HGNCID:	264	Length:	332	Species:	Homo sapiens
Sequence 2:	NP_058857.2	Gene:	Adora2b / 29316	RGDID:	2050	Length:	332	Species:	Rattus norvegicus

Alignment Length:	332	Identity:	285/332 - (85%)
Similarity:	306/332 - (92%)	Gaps:	0/332 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAI 65
            |.||||||||||||||||||:||||||||||||.::.|||||||||||||.||||||||||||||
  Rat     1 MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAI 65

Human    66 TISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLW 130
            ||||||||||:.||||||||||||||||||||||||||||||.||||||.|||||||||:|||||
  Rat    66 TISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLW 130

Human   131 VLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPL 195
            ||||||||||||||||||.||:|||||.||.||:|||.|||||||||||||||||||||||||||
  Rat   131 VLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVLPPL 195

Human   196 LIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQ 260
            |||:|||||||:|||:|||..|||:||||||||||||||||||||||||||||||||:||:|||.
  Rat   196 LIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFH 260

Human   261 PAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQ 325
            ||..|:||||.||:|||||||||||||:|||||||||||:||:|||||:|||.|.|.|:||||.|
  Rat   261 PALAKDKPKWVMNVAILLSHANSVVNPVVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGQAGGQ 325

Human   326 PALGVGL 332
            ....:.|
  Rat   326 STFSLSL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADORA2B	NP_000667.1	7tmA_Adenosine_R_A2B	8..301	CDD:320197	260/292 (89%)
		TM helix 1	9..35	CDD:320197	24/25 (96%)
		TM helix 2	42..69	CDD:320197	25/26 (96%)
		TM helix 3	78..108	CDD:320197	29/29 (100%)
		TM helix 4	122..140	CDD:320197	16/17 (94%)
		Agonist binding. /evidence=ECO:0000250	173..182		8/8 (100%)
		TM helix 5	179..209	CDD:320197	27/29 (93%)
		TM helix 6	227..257	CDD:320197	28/29 (97%)
		Agonist binding. /evidence=ECO:0000250	247..254		6/6 (100%)
		Agonist binding. /evidence=ECO:0000250	266..276		6/9 (67%)
		TM helix 7	269..294	CDD:320197	21/24 (88%)
Adora2b	NP_058857.2	7tm_GPCRs	8..301	CDD:421689	260/292 (89%)
		TM helix 1	9..35	CDD:410628	24/25 (96%)
		TM helix 2	42..69	CDD:410628	25/26 (96%)
		TM helix 3	78..108	CDD:410628	29/29 (100%)
		TM helix 4	122..140	CDD:410628	16/17 (94%)
		Agonist binding. /evidence=ECO:0000250	173..182		8/8 (100%)
		TM helix 5	179..209	CDD:410628	27/29 (93%)
		TM helix 6	227..257	CDD:410628	28/29 (97%)
		Agonist binding. /evidence=ECO:0000250	247..254		6/6 (100%)
		Agonist binding. /evidence=ECO:0000250	266..276		6/9 (67%)
		TM helix 7	269..294	CDD:410628	21/24 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83686836
Domainoid	1	1.000	487	1.000	Domainoid score	I7688
eggNOG	1	0.900	-	-		E33208_3BF5B
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20167
Inparanoid	1	1.050	583	1.000	Inparanoid score	I10410
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48050
OrthoDB	1	1.010	-	-		D127867at9347
OrthoFinder	1	1.000	-	-		FOG0000536
OrthoInspector	1	1.000	-	-		oto137344
orthoMCL	1	0.900	-	-		OOG6_116730
Panther	1	1.100	-	-	LDO	PTHR24246
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X919
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270