DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ecel1 and Nepl4

DIOPT Version :9

Sequence 1:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus
Sequence 2:	NP_609019.1	Gene:	Nepl4 / 33889	FlyBaseID:	FBgn0031805	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	782	Identity:	173/782 - (22%)
Similarity:	286/782 - (36%)	Gaps:	221/782 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    78 AMLALKYLGPGAAGGGGACP-------EGCP---ERKAFARAARF--LSANLDASIDPCQDFYSF 130
            |:|.|     |:|..|.:.|       :.||   |..:.......  |.:.:|:..:||:|||::
  Fly     8 ALLLL-----GSATCGSSVPVKANDPEQSCPYLGECNSTINQQHIDTLMSYVDSEKNPCEDFYAY 67

Mouse   131 ACGGWLRRHAIPDDKLTYGTIAAIGE-----QNEERLRRLLARPTGGPGGAAQ-RKVRAFFRSCL 189
            |||.|..:|.      ::.|...|.|     |.|:...:||..|:....|... .||.|.::||:
  Fly    68 ACGKWRAKHG------SHTTATMISESQINRQYEDLFLQLLRNPSAPEYGYPMFAKVLAHYQSCI 126

Mouse   190 -----DMREIERLGPRPMLEVIEDCGGWDLGGAADRPG--------AARWDLNRLLYKAQGVYSA 241
                 |:|....|..|.:|..:.......|..|..|.|        ..||            |:|
  Fly   127 ALEKPDLRRYIELLDRDLLASLNSTHWMHLLAALGRYGYHGHYVQVEVRW------------YNA 179

Mouse   242 A--ALF----------SLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFM 294
            .  .:|          |||..:.|        .:.|||.:.|  .|:..|::        :|...
  Fly   180 THHMIFLLPHNRHLNLSLTQDIYD--------ALSQDGSSWP--PLHQLQEQ--------FRSLE 226

Mouse   295 QRLLRLLGADAVEQKAQEILQLEQRLANISVSEYDDLRRDVSSAYNKVTLGQLQKIIPHLQWKWL 359
            |.|:||....:.                      ||..|:.|       |.|::..:|.|.|...
  Fly   227 QNLVRLAKPHSA----------------------DDTFRNYS-------LDQIRTEVPGLHWDEA 262

Mouse   360 L----------DQIFQ-EDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHL 413
            |          :.:|| :|....|.:|    :|:..|..|       :|:.|.:.|.:..|.|..
  Fly   263 LRTQLGRSVPGNHVFQVDDLDAIEGLV----EYLNTVDTL-------LLNRYSLARFLSHLLELP 316

Mouse   414 SSPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIK 478
            .:|.  |..|..:...|        |.|:....|...:.:.  :|:|....:.:....:||  |.
  Fly   317 HNPL--ATWESGQRSRG--------RNCIRHMRRSVYLPMN--YVYERSFYSRRRHADELV--IH 367

Mouse   479 YILGQRLEELDWMDAQTKA---------AARAKLQYMMVMVGYPDFLLKPEAVDKEY-----EFE 529
            .:..|...:|: :..|..|         :.:||:..|.:.||.    |.|...::.|     .:.
  Fly   368 SVFQQLQSQLE-LRVQHNAFNLSQDLVKSLQAKVHQMRINVGN----LPPNVTEQFYWDSDRRWS 427

Mouse   530 VHEKTYFKNILNSI--RFSIQLSVKKIRQEVDKSSWL-----LP--PQALNA--YYLPNKNQMVF 583
            | .:.:::|.|||:  .:::...::....:.::..|.     .|  |..::|  |:....|.:..
  Fly   428 V-GRDFYENHLNSLLYYYTLVADLESSSDQEERDIWYSFNMHTPEFPDNIDATPYFYCLGNIIFV 491

Mouse   584 PAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAE 648
            |...::...:|.:|..:|.||.:...:|||:.|.:|.....||..|||      .::|..|.:.|
  Fly   492 PYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYDAQGNL------RNFSDQLGEVE 550

Mouse   649 CIVRLYDNFTVYNQRVNGKHT----LGENIADMGGLKLAYYAY-QKWVREHGPEHPLHRLKYTHN 708
                      :||..|...::    |.|..:|:.|.:||...| ..|:...|           :.
  Fly   551 ----------LYNGAVGCLNSSAVMLNERTSDVSGSRLAMQTYGGDWLTRSG-----------NG 594

Mouse   709 QLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCS 773
            :|:|:.||..:|.....|      ..|..:......||.|.||.|   .|.|...|.|....:|.
  Fly   595 RLYFLQFAHFFCGDEGDQ------YHDSGSQRLNYALGQVPQFAE---VFRCHVGSGMTSADQCP 650

Mouse   774 VW 775
            .|
  Fly   651 FW 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	159/723 (22%)
Nepl4	NP_609019.1	PepO	51..643	CDD:226118	159/723 (22%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:301352	159/721 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910