Protein Alignment Ebf2 and kn

DIOPT Version :10

• Sequence 1: NP_034225.1
• Gene: Ebf2 / 13592
• MGIID: 894332
• Length: 575
• Species: Mus musculus
• Sequence 2: NP_001097317.1
• Gene: kn / 45318
• FlyBaseID: FBgn0001319
• Length: 689
• Species: Drosophila melanogaster
• Alignment Length: 600
• Identity: 353/600 - (58%)
• Similarity: 399/600 - (66%)
• Gaps: 124/600 - (20%)

Mouse     1 MFGIQDTLG------RGP--ALKDKSLGAEMDSVRSWVRNVGVVDANVAAQSGVALSRAHFEKQP 57
            |||:..|..      |||  :||::.||:.      |... .|||     ||.:.:.||||||||
  Fly   154 MFGLPPTAAVDMNQPRGPMTSLKEEPLGSR------WAMQ-PVVD-----QSNLGIGRAHFEKQP 206

Mouse    58 PSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEKTNNGTHYKLQLLYSNGVRTE 122
            |||||||||||||:|||||.|||:|||||||:.|:|.|.|....|||||..|:|||||:||.|.|
  Fly   207 PSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGARQE 271

Mouse   123 QDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFL 187
            ||::||||||||||.|.||||:||||||||||||||||||||:||||||||||||||||||||||
  Fly   272 QDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFL 336

Mouse   188 KFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSE-- 250
            ||||||||||||.|||||||||||||:||.|.|||.:||:||||||||||||||||:|||.:|
  Fly   337 KFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRLDTTEGT 401

Mouse   251 ---------------------------ATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGT 288
                                       |||||||||||||||||||.|||:||||||||||||||
  Fly   402 GNTSLSISGHPLAPDSTYDGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGT 466

Mouse   289 MLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIY-TALNEPTIDYGFQRLQK 352
            |||||||||.||||||||||||||||||||||||||||||:||||:| :||||||||||||||||
  Fly   467 MLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRLQK 531

Mouse   353 VIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNPSQIPALSS 417
            :|||||||||:|.||::||||||||                      |||||:||:|
  Fly   532 LIPRHPGDPEKLQKEIILKRAADLV----------------------EALYSMPRSP-------- 566

Mouse   418 SPAHSGMMGINSYGSQLGVSISE-STQGNNQGYIR-NTSSISPRG--YSSSSTPQQS--NYSTSS 476
                .|..|.|||..||.||:.: |.|.....|.| .:||:||||  .||:|||..|  :|..::
  Fly   567 ----GGSTGFNSYAGQLAVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSSASTPHSSGGSYGATA 627

Mouse   477 NS------MNGYSNVPMANLGVPGSPGFLNGSPTGSPYGIMSSSPTVGSSSTSSILPFSSSVFPA 535
            .|      .|||:  |..|:|.                  :||||....:|||.:...|.:.|.
  Fly   628 ASAAVAATANGYA--PAPNMGT------------------LSSSPGSVFNSTSRVSSLSFNPFA- 671

Mouse   536 VKQKSAFAPVIRPQG 550
                   .|....||
  Fly   672 -------LPTCNTQG 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ebf2	NP_034225.1	COE1_DBD	20..246	CDD:435333	170/225 (76%)
		Interaction with DNA. /evidence=ECO:0000250	62..65		2/2 (100%)
		Interaction with DNA. /evidence=ECO:0000250	196..203		5/6 (83%)
		Interaction with DNA. /evidence=ECO:0000250	235..238		2/2 (100%)
		IPT_COE	253..337	CDD:238580	78/84 (93%)
		COE1_HLH	338..381	CDD:406751	35/42 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..479		18/48 (38%)
kn	NP_001097317.1	COE_DBD	184..395	CDD:212156	169/216 (78%)
		IPT_COE	431..515	CDD:238580	78/83 (94%)
		COE1_HLH	517..560	CDD:406751	37/64 (58%)