DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ebf1 and kn

DIOPT Version :10

Sequence 1:NP_001277638.1 Gene:Ebf1 / 13591 MGIID:95275 Length:592 Species:Mus musculus
Sequence 2:NP_001097317.1 Gene:kn / 45318 FlyBaseID:FBgn0001319 Length:689 Species:Drosophila melanogaster


Alignment Length:617 Identity:370/617 - (59%)
Similarity:421/617 - (68%) Gaps:116/617 - (18%)


- Green bases have known domain annotations that are detailed below.


Mouse     1 MFGIQESI-----QRSG--SSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQP 58
            |||:..:.     |..|  :|:|||||||     |..||  .|:|     ||.:|:.||||||||
  Fly   154 MFGLPPTAAVDMNQPRGPMTSLKEEPLGS-----RWAMQ--PVVD-----QSNLGIGRAHFEKQP 206

Mouse    59 PSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTE 123
            |||||||||||||:|||||.|||:|||||||:||:||:.|:::.||||||.|||||||:||.|.|
  Fly   207 PSNLRKSNFFHFVIALYDRAGQPIEIERTAFIGFIEKDSESDATKTNNGIQYRLQLLYANGARQE 271

Mouse   124 QDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFL 188
            ||.:||||||:|||||:||||||||||||||||||:|||||||||||||||||||||||||||||
  Fly   272 QDIFVRLIDSVTKQAIIYEGQDKNPEMCRVLLTHEVMCSRCCDKKSCGNRNETPSDPVIIDRFFL 336

Mouse   189 KFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGT 253
            ||||||||||||||||||||||||||:||.|.|||.:||:||||||||||||||||:|||.:|||
  Fly   337 KFFLKCNQNCLKNAGNPRDMRRFQVVISTQVAVDGPLLAISDNMFVHNNSKHGRRAKRLDTTEGT 401

Mouse   254 P----SYLEH----------------AATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGT 298
            .    |...|                .|||||||||||||||||||||||:||||||||||:|||
  Fly   402 GNTSLSISGHPLAPDSTYDGLYPPLPVATPCIKAISPSEGWTTGGATVIIVGDNFFDGLQVVFGT 466

Mouse   299 MLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIY-TALNEPTIDYGFQRLQK 362
            |||||||||.||||||||||||||||||||||||||||||:||||:| :||||||||||||||||
  Fly   467 MLVWSELITSHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGSPGRFVYVSALNEPTIDYGFQRLQK 531

Mouse   363 VIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALAN 427
            :|||||||||:|.||:|||||||||||||.||.:                               
  Fly   532 LIPRHPGDPEKLQKEIILKRAADLVEALYSMPRS------------------------------- 565

Mouse   428 TSVHAGMMGVNSFSGQLAVNVSEAS-QATNQGFTR-NSSSVSPH-GYVPS-TTPQQTNYNSVTTS 488
               ..|..|.||::|||||:|.:.| |.|...:.| .||||||. ||..| :||.        :|
  Fly   566 ---PGGSTGFNSYAGQLAVSVQDGSGQWTEDDYQRAQSSSVSPRGGYCSSASTPH--------SS 619

Mouse   489 MNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAV 553
            ...||:.|.|  .......||      ||..|:..|::||.....|.:|.....||:|..:    
  Fly   620 GGSYGATAAS--AAVAATANG------YAPAPNMGTLSSSPGSVFNSTSRVSSLSFNPFAL---- 672

Mouse   554 KQKSAFAPVVRPQTSPPPTCTSTNGNSLQAIS 585
                             ||| :|.|.|.|.::
  Fly   673 -----------------PTC-NTQGYSTQLVT 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ebf1NP_001277638.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 10/26 (38%)
COE1_DBD 21..247 CDD:435333 178/225 (79%)
Interaction with DNA. /evidence=ECO:0000269|PubMed:20876732, ECO:0007744|PDB:3MLN, ECO:0007744|PDB:3MLO, ECO:0007744|PDB:3MLP 63..66 2/2 (100%)
Interaction with DNA. /evidence=ECO:0000269|PubMed:20876732, ECO:0007744|PDB:3MLN, ECO:0007744|PDB:3MLO, ECO:0007744|PDB:3MLP 197..204 6/6 (100%)
Interaction with DNA. /evidence=ECO:0000269|PubMed:20876732, ECO:0007744|PDB:3MLN, ECO:0007744|PDB:3MLO, ECO:0007744|PDB:3MLP 236..239 2/2 (100%)
IPT_COE 263..347 CDD:238580 78/84 (93%)
COE1_HLH 348..391 CDD:406751 38/42 (90%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..481 12/25 (48%)
knNP_001097317.1 COE_DBD 184..395 CDD:212156 175/217 (81%)
IPT_COE 431..515 CDD:238580 78/83 (94%)
COE1_HLH 517..560 CDD:406751 38/42 (90%)

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