DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CPA3 and CG17633

DIOPT Version :9

Sequence 1:	NP_001861.2	Gene:	CPA3 / 1359	HGNCID:	2298	Length:	417	Species:	Homo sapiens
Sequence 2:	NP_609310.2	Gene:	CG17633 / 34297	FlyBaseID:	FBgn0032144	Length:	430	Species:	Drosophila melanogaster

Alignment Length:	422	Identity:	132/422 - (31%)
Similarity:	224/422 - (53%)	Gaps:	29/422 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     9 LIATTLAIAP--------VRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHVAANMM 65
            |:...|||..        ||:|..::::|..::.||.:::|||..:::...:..| .|.|.|::.
  Fly     7 LLFALLAIVASASVSAERVRYDNYRMYKVNSENAKQLEVLKDLEGSSDSIMFLDG-VHLVGADIQ 70

Human    66 VDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGR----HSYAKYNNWEKIV 126
            :  .|:..:.......|.::::.||:...|:|:.:: :.|.|..|.||    :::|:|...:...
  Fly    71 I--IVAPHKVPDFLEILGKSEIKYELQSRDVQKSLD-EIDEKVAIKGRATTAYNWAQYYELDDTY 132

Human   127 AWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKI---GE--KNERRKAIFTDCGIHAREWVSPAFC 186
            ||.:.:....|.:|:.|:.|.|.:...:..:||   ||  ..:.:..||.:.|||||||::||..
  Fly   133 AWLQSLAQTNPGVVTLIEGGKTYQGRSILGVKITKGGETINGKAKPGIFLEAGIHAREWIAPAAA 197

Human   187 QWFVYQATKTYGRNKIMTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLN 251
            .:.:.|...:...|  :.:|.:...:|:||..|.|||:::.|.||:|||.|:  ....|.|.|.|
  Fly   198 TFIINQLLTSEVEN--IKELAENYTWYVLPHANPDGYVYTHTTNRLWRKTRT--PYGSCFGADPN 258

Human   252 RNFNASWNSIPNTNDPCADNYRGSAPESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGY 316
            ||:...||.:..::..|:|.|.|.:..||.||.:::.||.....::::|::.|:|||.||:|||:
  Fly   259 RNWGFHWNEVGASSSACSDTYAGPSAFSEIETLSLSKFIEGLKGKVQLYLSLHAYSQYLLYPYGH 323

Human   317 TSKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDL-GIKHTFAFELR 380
            ||.||.|..|..||.......::.||.|.|..|.|...|||.:|:|:||||.. .::..|.:|||
  Fly   324 TSDLPDNVADFEKVFDASIAAVNKRYGTTYTGGNIYDAIYPAAGASVDWAYGTQDVRMAFCYELR 388

Human   381 DKGK---FGFLLPESRIKPTCRETMLAVKFIA 409
            ....   .||.||..:|.|...|.:.::..:|
  Fly   389 PSSTSYLTGFKLPAEQIVPASEELLDSIVAMA 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CPA3	NP_001861.2	Propep_M14	28..102	CDD:280416	16/73 (22%)
CPA3	NP_001861.2	M14_CPB	114..413	CDD:199852	104/305 (34%)
CG17633	NP_609310.2	MpaA	7..374	CDD:225421	118/374 (32%)
		Propep_M14	34..105	CDD:280416	16/74 (22%)
		M14_CP_A-B_like	125..423	CDD:199844	103/300 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2866
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208397at33208
OrthoFinder	1	1.000	-	-		FOG0000056
OrthoInspector	1	1.000	-	-		mtm8518
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1730
SonicParanoid	1	1.000	-	-		X86
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.780