DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TRIM50 and IRC20

DIOPT Version :9

Sequence 1:	NP_001268380.1	Gene:	TRIM50 / 135892	HGNCID:	19017	Length:	487	Species:	Homo sapiens
Sequence 2:	NP_013348.1	Gene:	IRC20 / 850949	SGDID:	S000004237	Length:	1556	Species:	Saccharomyces cerevisiae

Alignment Length:	317	Identity:	70/317 - (22%)
Similarity:	111/317 - (35%)	Gaps:	111/317 - (35%)

- Green bases have known domain annotations that are detailed below.

Human     6 SLPELEDR------LQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSS 64
            :|..|:|.      |.|.|||...:...:::|||.:||.|:::   .|.|..:||:|:    |..
Yeast  1223 NLSRLKDTLNDNQILSCSICLGEVEIGAIIKCGHYFCKSCILT---WLRAHSKCPICK----GFC 1280

Human    65 SLPNV----------SLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGS--H 117
            |:..|          ...:.|:..|..|....:...:..:.:|...|.::        |.|:  .
Yeast  1281 SISEVYNFKFKNSTEKREKEIQEPRREGADSSQDNSNENSIISNMSEVEK--------LFGNKYE 1337

Human   118 QHHPVTPVSTVYSRMKEELAA-------LIS--ELKQEQKKVDELIAKLVNNRTRIVNESDVFSW 173
            |.|.:..|..::  :||...|       |||  .||.||:..|.....|.:.:|..:.   |...
Yeast  1338 QFHQINEVHQIH--IKESFGAKIDFVIKLISYLRLKSEQENADPPQVILYSQKTEYLK---VIGK 1397

Human   174 VIRREFQELHHLVDEEKARCL-------EGIGGHTR----------------GL-------VASL 208
            |::     |:|:   |...||       |.|....|                ||       :..|
Yeast  1398 VLK-----LYHI---EHLACLSNTANVGETINNFKRQPSVTCLLLNVKTLGAGLNLINAKHIFLL 1454

Human   209 DMQLE-----QAQGTRERLAQAE---------------------CVLEQFGNEDHHK 239
            |..|.     ||.|...|:.|.|                     |:||:...::..|
Yeast  1455 DPILNNSDELQAMGRNNRIGQDEETFVWNFMIRNTVEENILRYKCILEERKRKEKSK 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TRIM50	NP_001268380.1	RING-HC_TRIM50_like_C-IV	14..58	CDD:319519	16/43 (37%)
		RING-HC finger (C3HC4-type)	16..56	CDD:319519	14/39 (36%)
		BBOX	90..125	CDD:237988	6/36 (17%)
		SPRY_PRY_TRIM50	283..469	CDD:293977
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	468..487
IRC20	NP_013348.1	HepA	172..>568	CDD:223627
		DEXQc_SHPRH	383..602	CDD:350828
		RAD18	1234..>1327	CDD:227719	23/99 (23%)
		RING-HC_RNF10	1239..1276	CDD:319450	14/39 (36%)
		SF2_C_SNF	1356..1485	CDD:350180	32/139 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910