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Protein Alignment CPA1 and CG12374

DIOPT Version :9

Sequence 1:	NP_001859.1	Gene:	CPA1 / 1357	HGNCID:	2296	Length:	419	Species:	Homo sapiens
Sequence 2:	NP_610819.1	Gene:	CG12374 / 36410	FlyBaseID:	FBgn0033774	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	132/434 - (30%)
Similarity:	227/434 - (52%)	Gaps:	50/434 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     4 LLVLSVLLGAVFGKEDFVGH--------QVLRISVADEAQVQKVKELEDLEHLQLDFWRGPAHPG 60
            |.:|.:.|.|:...:...|.        ::.::::....|::::|::.  ||:.:.|.......|
  Fly     3 LPILLITLVAMVAAKSAPGRMAARYDHFRIYQLTIETNLQMEELKKIH--EHISVHFLNELGAVG 65

Human    61 SPIDVRV-PF--PSIQAVKIFLESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATY 122
            :..:|.| |.  .:::....|||   |.||.:::|:|.|:||         |.........:.||
  Fly    66 NKYNVIVGPLFHRALEKTLKFLE---IVYEVIVDDLQKLIDE---------SSVGDDSQMEWETY 118

Human   123 HTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFS-TGGSKRPAIWIDTGIHSREWVTQ 186
            |||:.|||::|...|.:..|..|: ||.:||||.|..::.| ..|:|  ||:::..||:.||::.
  Fly   119 HTLDTIYDWIDQECAAHDFLECKV-IGQSYEGRDIKSIRLSKRSGNK--AIFLEGNIHAMEWISS 180

Human   187 ASGVWFAKKITQDYGQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTR-----SHTAGS 246
            |:..:...::..  .:|.....:.:..|..:..:.|||||.:||...|:|||.|     .:.:|.
  Fly   181 ATVTFLLNQLIN--SEDPEMQRLSEEYDWIVVPMVNPDGFVYTHEVERLWRKNRRPNGYRNESGD 243

Human   247 LCIGVDPNRNWDAGFGLSGASSN---PCSETYHGKFANSEVEVKSIVDFVK--DHGNIKAFISIH 306
             |.|:|.|||:|..:|  ||..|   ||...:.|:..|:|||:.|:.:||.  :.|.|:::::.|
  Fly   244 -CYGIDMNRNFDYHWG--GAGWNIDEPCDHWFGGEEPNTEVEIISLQNFVSSFEDGYIRSYMAYH 305

Human   307 SYSQLLMYPYGY-KTEPVPDQDELDQLSKAAVTALASLYGTKFNYGSIIKAIYQASGSTIDWTYS 370
            :|.|.::.|||: .||..|:.:::.:::.|...|.|.:||:.|.||:.....|..||:..||.|
  Fly   306 AYGQYVLLPYGHSNTEFPPNYEQMKRIAAAFSDAAADVYGSTFTYGASGLLNYVVSGAAKDWAY- 369

Human   371 QGIK---YSFTFELRDTGRYGFLLPASQIIPTAKETWLALLTIM 411
             |:|   ::.|.||||.|.:||.||::||.....|....|..::
  Fly   370 -GVKKIPFTCTVELRDKGTFGFFLPSNQITEVGLEVTAGLKALV 412

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.