DRSC/TRiP Functional Genomics Resources

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Protein Alignment CPA1 and CG32379

DIOPT Version :9

Sequence 1:NP_001859.1 Gene:CPA1 / 1357 HGNCID:2296 Length:419 Species:Homo sapiens
Sequence 2:NP_729252.2 Gene:CG32379 / 326211 FlyBaseID:FBgn0052379 Length:344 Species:Drosophila melanogaster


Alignment Length:340 Identity:106/340 - (31%)
Similarity:176/340 - (51%) Gaps:20/340 - (5%)


- Green bases have known domain annotations that are detailed below.


Human    79 LESHGISYETMIEDVQSLLDEEQEQMFAFRSRARSTDTFNYATYHTLEEIYDFLDLLVAENPHLV 143
            :.::.:.|:.:|||:..|:..::.:....:...:.......:.::|..||.|:||.|:...|..|
  Fly     1 MRNYHLEYKVLIEDLAPLVHAQRAENLRKKLLIQWPHIDVLSAFYTHSEINDYLDSLLERFPKRV 65

Human   144 SKIQIGNTYEGRPIYVLKFSTGGSKR--PAIWIDTGIHSREWVTQASGVWFAKKITQDYGQDAAF 206
            ...|.|.:||.||:.||..:.|..:|  |.|.||..:|:|||::.:..::..:::..:||.:   
  Fly    66 QVKQFGWSYERRPLKVLTITNGDGRRNKPVILIDGTVHAREWISPSMALYIIQQLLDNYGDN--- 127

Human   207 TAILDTLDIFLEIVTNPDGFAFTHSTNRMWRKTRSHTAGSLCIGVDPNRNWDAGFGL-SGASSNP 270
            ..:|...|..:..|.|.||:.:||:.:|.|||:|..|:...|||.|.|||:...:|. .|:||:|
  Fly   128 QELLQDYDWVIMPVVNADGYEYTHTDSRYWRKSRRPTSNPECIGTDINRNFGYEWGHDEGSSSDP 192

Human   271 CSETYHGK--FANSEVEV-KSIVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEPVPDQDELDQL 332
            |...|.|:  |..||.:| :.::...|  |.:..::|:|||....:.|:|| |...||..: |.:
  Fly   193 CENIYRGERPFDQSESQVLRDVMLHYK--GRLNFYLSLHSYGNYFLLPWGY-TSDFPDTYQ-DMM 253

Human   333 SKAAVTALASLYGTK--FNYGSIIKAIYQASGSTIDWTYSQGI---KYSFTFELRDTGRYGFLLP 392
            |.|...|.|.:|.|.  ::|||....:|..||.|.|:.:  |:   ..:.|.||...|..||...
  Fly   254 SVADAGAKAIIYSTNGIYSYGSTYYVLYPTSGDTTDFAF--GVVNATVAMTMELPAAGFQGFDPW 316

Human   393 ASQIIPTAKETWLAL 407
            .|||.....|:|:.:
  Fly   317 ISQIERLVTESWVGV 331

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CPA1NP_001859.1 Propep_M14 32..100 CDD:396700 5/20 (25%)
M14_CPA 117..417 CDD:349442 101/302 (33%)
Substrate binding. /evidence=ECO:0000269|PubMed:18566513, ECO:0007744|PDB:2V77 179..182 1/2 (50%)