DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E4f1 and Cp190

DIOPT Version :9

Sequence 1:	NP_001288713.1	Gene:	E4f1 / 13560	MGIID:	109530	Length:	783	Species:	Mus musculus
Sequence 2:	NP_524359.2	Gene:	Cp190 / 41848	FlyBaseID:	FBgn0000283	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	156/786 - (19%)
Similarity:	263/786 - (33%)	Gaps:	249/786 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse   198 CHKT--FKTGSILKAHMVTHSSRKDH--------------------------------------- 221
            |..|  |:..|.||.|.:..|:..|:
  Fly    30 CDLTLQFRDNSQLKVHRLVLSACTDYFNVLEQTCEIVDDALIMPNEFQADVVVPIVNFMYTGTLE 94

Mouse   222 -ECKLCGASFRTKG--------SLIRHHRR-----HTDERPYKCAKCGKSFR-------ESGALT 265
             |.|:.|...||..        .|:..|||     :..:||    ...|..|       .||...
  Fly    95 FELKMYGKLLRTAKEMNMTVLLKLLEAHRRTMENVNRQQRP----PSPKGIRRRTVGQPSSGLPQ 155

Mouse   266 RHLKSLTPCTEKIRFSISK-------DTAVGKEEVPAGSSASTVGTVTSSVAGDPMETSPVIHLV 323
            :.:...:|.:..:...|::       .|.........||:.|..|. :|:|..:|  |||...|
  Fly   156 QRVLGPSPQSRNVATPIAQRANTQRGSTGNTMSRTSGGSNRSPYGD-SSNVKQEP--TSPFEQL- 216

Mouse   324 TDAKGTVIHEVHVQMQELPLGMKALTPES--PDSEELP--CSSENSRENLLHQAMQN-----SGI 379
              .||       ....:.|.....|:|.|  |..||:.  ...:..|:.:..:...|     .|:
  Fly   217 --RKG-------YNNNKRPAQTSLLSPPSKKPSLEEVKEFAEQQRMRKQIAAEYGDNDPEYDGGM 272

Mouse   380 VLERV-AG--EESALEPAP-------PSGSSPQCLGDGSPELPLLKVE---QIETQVASEAATVP 431
            :.:.| ||  ::..:.|.|       |.|:..| |..||..: :||.:   |..|.:..:::...
  Fly   273 LYDDVHAGDDDDDDMPPQPSTSKQQSPQGTQTQ-LEHGSTTI-ILKQDSPSQTPTIIVKDSSNAK 335

Mouse   432 RTH-----------------------------PCPQCSETFP---------TAATLEAHKRGHIA 458
            ..|                             |.....::.|         ::||...||:.|::
  Fly   336 LNHTKIIAEVLRQYPHIVKGHKNIKLKIMPNTPAAPTEKSAPATVKPPANQSSATTSPHKKLHVS 400

Mouse   459 PRPFTCTQCGKAFPKAYLLKKH------------------QEVHVHERR---------------- 489
            .:....|....|..||...::.                  ......:||
  Fly   401 FKADKSTPLITAQQKAASSQQKSGTSQTTGNQGTGANPPANTAAAQKRRIDSKTMHALIAQGAEN 465

Mouse   490 -------FRCGDCGKLYKTIAHVRGHRR----VHSDE-RPFPCPQCGKRYKTKNAQQVHFRTHLE 542
                   .|||..|:.. :|...||.||    .|.:. .|..|..||  :::.|.:::||..::|
  Fly   466 TTGPWLCLRCGVNGRPI-SIPSYRGFRRHLINTHKETIDPALCEHCG--WRSVNNRELHFHMYME 527

Mouse   543 EKPH-------VCQFCSRGFREKGSLVRHVRH-HTGEKPFKCYKCGRGFAEHGTLNRHLRT---- 595
            .:..       .|..|::.:|.||.|..|:.. ||.:...:|..|.:.|.:...|.||:::
  Fly   528 HQTKSLLYTFAECALCNQSYRTKGELEAHINEVHTDDNKQQCIYCNKVFEQELQLYRHMKSYHKE 592

Mouse   596 ---KGGCLLEV-EELLVSEESPSAAATVLAEDPHTVLVEFSSVVADTQEYIIEATADDTETSEAT 656
               :.|.:.|. ||.|.|::....|.....::|     |.:..|....:..:.||:       |.
  Fly   593 QALEDGIIDETDEEFLGSQDEEEEAEGDEEQEP-----EQTGKVRILSDISLPATS-------AI 645

Mouse   657 EIIEGTQTEVDSHIMKVVQQIVHQAGA-GHQIIVQNVTMDQETALGSE-------ATAADTI-TI 712
            .:.:..|.::....::.|||.|...|| |:::   .:|.:|...:.|:       |||...: .:
  Fly   646 TVQQAQQEQLQEEDVEQVQQEVKFVGADGNEV---ELTDEQRKEILSQLNQQQAGATAGGVVMVL 707

Mouse   713 ATPESLTEQVAMTLASAISEGT--------VLTARAGPNSTEQA--TVTMVSSEDIEILEHGGEL 767
            :.||:  |.|..........||        :.:.....:|.|.|  .:...|.|.|:.||....|
  Fly   708 SEPEA--EHVKQETDEKSLAGTEEEYDDSQIYSELGAADSVESAKKNIADESKESIDNLEWAENL 770

Mouse   768 VIASPE 773
            :..|.|
  Fly   771 IAESEE 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E4f1	NP_001288713.1	Required for ubiquitin ligase activity. /evidence=ECO:0000250	40..84
		Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2. /evidence=ECO:0000250	185..264		24/127 (19%)
		COG5048	193..594	CDD:227381	112/578 (19%)
		C2H2 Zn finger	195..215	CDD:275368	7/18 (39%)
		zf-C2H2	221..243	CDD:278523	9/74 (12%)
		C2H2 Zn finger	223..243	CDD:275368	8/32 (25%)
		zf-H2C2_2	235..258	CDD:290200	7/27 (26%)
		C2H2 Zn finger	251..269	CDD:275368	4/24 (17%)
		Mediates interaction with CDKN2A. /evidence=ECO:0000250	368..565		55/305 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..407		7/29 (24%)
		Interaction with BMI1. /evidence=ECO:0000250	434..598		47/262 (18%)
		C2H2 Zn finger	436..456	CDD:275368	5/28 (18%)
		zf-C2H2	462..484	CDD:278523	4/39 (10%)
		C2H2 Zn finger	464..484	CDD:275368	4/37 (11%)
		C2H2 Zn finger	492..512	CDD:275368	8/23 (35%)
		zf-H2C2_2	504..529	CDD:290200	9/29 (31%)
		Mediates interaction with TP53. /evidence=ECO:0000250	520..579		17/66 (26%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		zf-H2C2_2	534..555	CDD:290200	5/27 (19%)
		C2H2 Zn finger	548..568	CDD:275368	7/20 (35%)
		zf-H2C2_2	560..584	CDD:290200	6/24 (25%)
		Mediates interaction with RASSF1. /evidence=ECO:0000250	574..596		6/28 (21%)
		C2H2 Zn finger	576..595	CDD:275368	6/18 (33%)
Cp190	NP_524359.2	BTB	20..122	CDD:279045	15/91 (16%)
		BTB	31..127	CDD:197585	17/95 (18%)
		C2H2 Zn finger	540..568	CDD:275371	9/27 (33%)
		C2H2 Zn finger	569..586	CDD:275371	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5423
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950