Protein Alignment E4f1 and CG14667

DIOPT Version :9

• Sequence 1: NP_001288713.1
• Gene: E4f1 / 13560
• MGIID: 109530
• Length: 783
• Species: Mus musculus
• Sequence 2: NP_001014607.1
• Gene: CG14667 / 40643
• FlyBaseID: FBgn0037317
• Length: 337
• Species: Drosophila melanogaster
• Alignment Length: 251
• Identity: 66/251 - (26%)
• Similarity: 109/251 - (43%)
• Gaps: 44/251 - (17%)

Mouse   334 VHVQMQELPLGMKALTPES----PDSEELPCSSENSRENLLHQAMQNSGIVLER------VAGEE 388
            |||::...||..:.:..:.    .|.::..|......|   ||.::.  |.|:.      :|..|
  Fly    91 VHVELSSEPLDEQLIDADQLETHYDDDQYVCYQGTKEE---HQDLEE--IELDDDPSAAVIAAAE 150

Mouse   389 SALEPAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTH--PCPQCSETFPTAATLEA 451
            :|.|.|                    :.|.::.| ..|.|...|::  .|.:|...|..|.....
  Fly   151 AAAEAA--------------------QQEDLQEQ-EMERAAKRRSNFFICDECGTLFHDAFLYTE 194

Mouse   452 HKRGHIAPRP----FTCTQCGKAFPKAYLLKKHQ-EVHVHERRFRCGDCGKLYKTIAHVRGHRRV 511
            |..||...|.    |.|.:|.:.|.|..|||:|: :||:..|||:|..|.:.:.::.....|.:.
  Fly   195 HLNGHQNRRDMNQFFPCPECPQTFNKKALLKQHRTQVHLINRRFQCTICHEAFASLGAKLRHDKA 259

Mouse   512 HSDERPFPCPQCGKRYKTKNAQQVHFRTHLEE-KPHVCQFCSRGFREKGSLVRHVR 566
            |.:|||:||.:||..:.:.:..|.||.||.:: :...|:.|:..|..:..||.|.:
  Fly   260 HKNERPYPCLECGMIFSSVSELQNHFSTHSKQIRKFRCEPCNMDFITRRGLVAHTK 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E4f1	NP_001288713.1	Required for ubiquitin ligase activity. /evidence=ECO:0000250	40..84
		Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2. /evidence=ECO:0000250	185..264
		COG5048	193..594	CDD:227381	66/251 (26%)
		C2H2 Zn finger	195..215	CDD:275368
		zf-C2H2	221..243	CDD:278523
		C2H2 Zn finger	223..243	CDD:275368
		zf-H2C2_2	235..258	CDD:290200
		C2H2 Zn finger	251..269	CDD:275368
		Mediates interaction with CDKN2A. /evidence=ECO:0000250	368..565		57/210 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..407		4/20 (20%)
		Interaction with BMI1. /evidence=ECO:0000250	434..598		44/141 (31%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		zf-C2H2	462..484	CDD:278523	9/22 (41%)
		C2H2 Zn finger	464..484	CDD:275368	8/20 (40%)
		C2H2 Zn finger	492..512	CDD:275368	3/19 (16%)
		zf-H2C2_2	504..529	CDD:290200	9/24 (38%)
		Mediates interaction with TP53. /evidence=ECO:0000250	520..579		14/48 (29%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		zf-H2C2_2	534..555	CDD:290200	7/21 (33%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)
		zf-H2C2_2	560..584	CDD:290200	3/7 (43%)
		Mediates interaction with RASSF1. /evidence=ECO:0000250	574..596
		C2H2 Zn finger	576..595	CDD:275368
CG14667	NP_001014607.1	zf-AD	6..80	CDD:214871
		C2H2 Zn finger	179..199	CDD:275368	5/19 (26%)
		C2H2 Zn finger	211..232	CDD:275368	8/20 (40%)
		C2H2 Zn finger	240..260	CDD:275368	3/19 (16%)
		zf-C2H2_8	243..313	CDD:292531	20/69 (29%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		C2H2 Zn finger	297..316	CDD:275368	6/19 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5423
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950