DRSC/TRiP Functional Genomics Resources

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Protein Alignment E4f1 and CG11696

DIOPT Version :9

Sequence 1:NP_001288713.1 Gene:E4f1 / 13560 MGIID:109530 Length:783 Species:Mus musculus
Sequence 2:NP_572731.1 Gene:CG11696 / 32104 FlyBaseID:FBgn0030314 Length:664 Species:Drosophila melanogaster


Alignment Length:632 Identity:128/632 - (20%)
Similarity:199/632 - (31%) Gaps:248/632 - (39%)


- Green bases have known domain annotations that are detailed below.


Mouse     5 MAVRVTAAHTAE-ARAEAGREAGEGGVAAAAALSSGGFLGLPAPFSEEDEDDVHRCGRCQVEFTA 68
            :::|.:.|...| .|:.||.|..:.|                    :|||:|             
  Fly   207 LSLRESRARQRELKRSSAGAEDDQDG--------------------DEDEED------------- 238

Mouse    69 LEDFVQHKIQKTCHRAPQEALPTTPAATALLDQEVVPTAAEGGPDEPITVAHIVVEATSLAEDIS 133
             |:.|..::              ||.|    |::..|....|   .|.|...:..:..   :|.|
  Fly   239 -EEDVGGEL--------------TPDA----DEQPKPRGKRG---RPKTKKLVTADDN---DDTS 278

Mouse   134 HAPDLVGSGHIKEVIVAAEAEPGDVEMAEAPGSPNHQELGLLGEGEQAHVKLLVNKEGRYVCMLC 198
            ..|  |....|||:         |..:|                   |:|||        .|.:|
  Fly   279 EVP--VKRSSIKEM---------DDYIA-------------------ANVKL--------DCAIC 305

Mouse   199 HKTFKTGSILKAHMVTHSSRKDHEC----KLCGASFRTKGSLIRHHRRHTDERPYKCAKCGKSFR 259
            ....:..:.||.|.     |.:|:|    |.|...::.:...:.|...|.|.:.:.|..|.|:| 
  Fly   306 AAPLEDFNDLKRHF-----RVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNF- 364

Mouse   260 ESGALTRHLKSLTPCTEKIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGDPMETSPVIHLVT 324
                |.|:                                                 |.|:|:: 
  Fly   365 ----LNRN-------------------------------------------------SQVMHML- 375

Mouse   325 DAKGTVIHEVHVQMQELPLGMKALTPESPDSEELPCSSENSRENLLHQAMQNSGIVLERVAGEES 389
                    ..|.|.||| :...|:           |.:..:::.||...::          |.: 
  Fly   376 --------RFHSQQQEL-VHQCAI-----------CEARFAKKFLLTMHLK----------GHK- 409

Mouse   390 ALEPAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTHPCPQCSETFPTAATLEAH-K 453
                           |...||:                        |..||:||.|...|.|| |
  Fly   410 ---------------GTERPEV------------------------CDTCSKTFRTKFELSAHVK 435

Mouse   454 RGHIAP-RPFTCTQCGKAF-PKA-YLLKK---HQEVHVHERRFRCGDCGKLYKTIAHVRGHRRVH 512
            |.|.|. .|..|..||..| .|| :|:.|   |.:..|.|  .:|..||:..:....:|.|...|
  Fly   436 RMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAE--VQCTLCGRWLRDERSLRKHLARH 498

Mouse   513 SD---ERPFPCPQCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVRHHTGEKPF 574
            .|   :..:.|..|.....::.|...|.|.|...|.|.|..|.:.|:...:|..|:..|||...:
  Fly   499 DDRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDLY 563

Mouse   575 KCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEESPSAAATVLA 621
            :|..|.|.|..|..::.|.:.     :...:.:.....||::.|..|
  Fly   564 QCQFCTRTFKSHANMHNHKKK-----MHPNDWVRKYSQPSSSITSTA 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E4f1NP_001288713.1 Required for ubiquitin ligase activity. /evidence=ECO:0000250 40..84 6/43 (14%)
Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2. /evidence=ECO:0000250 185..264 18/82 (22%)
COG5048 193..594 CDD:227381 89/414 (21%)
C2H2 Zn finger 195..215 CDD:275368 5/19 (26%)
zf-C2H2 221..243 CDD:278523 5/25 (20%)
C2H2 Zn finger 223..243 CDD:275368 4/23 (17%)
zf-H2C2_2 235..258 CDD:290200 6/22 (27%)
C2H2 Zn finger 251..269 CDD:275368 6/17 (35%)
Mediates interaction with CDKN2A. /evidence=ECO:0000250 368..565 50/206 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 386..407 2/20 (10%)
Interaction with BMI1. /evidence=ECO:0000250 434..598 54/173 (31%)
C2H2 Zn finger 436..456 CDD:275368 11/20 (55%)
zf-C2H2 462..484 CDD:278523 9/26 (35%)
C2H2 Zn finger 464..484 CDD:275368 9/24 (38%)
C2H2 Zn finger 492..512 CDD:275368 5/19 (26%)
zf-H2C2_2 504..529 CDD:290200 6/27 (22%)
Mediates interaction with TP53. /evidence=ECO:0000250 520..579 17/58 (29%)
C2H2 Zn finger 520..540 CDD:275368 5/19 (26%)
zf-H2C2_2 534..555 CDD:290200 7/20 (35%)
C2H2 Zn finger 548..568 CDD:275368 5/19 (26%)
zf-H2C2_2 560..584 CDD:290200 8/23 (35%)
Mediates interaction with RASSF1. /evidence=ECO:0000250 574..596 6/21 (29%)
C2H2 Zn finger 576..595 CDD:275368 6/18 (33%)
CG11696NP_572731.1 zf-AD 2..78 CDD:285071
C2H2 Zn finger 332..349 CDD:275368 2/16 (13%)
C2H2 Zn finger 357..378 CDD:275368 9/83 (11%)
C2H2 Zn finger 388..408 CDD:275368 4/40 (10%)
C2H2 Zn finger 417..438 CDD:275368 11/20 (55%)
C2H2 Zn finger 447..465 CDD:275368 7/17 (41%)
C2H2 Zn finger 478..498 CDD:275368 5/19 (26%)
C2H2 Zn finger 509..529 CDD:275368 5/19 (26%)
C2H2 Zn finger 537..557 CDD:275368 5/19 (26%)
C2H2 Zn finger 565..583 CDD:275368 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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