DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk1b and Hipk

DIOPT Version :9

Sequence 1:	NP_001258299.1	Gene:	Dyrk1b / 13549	MGIID:	1330302	Length:	689	Species:	Mus musculus
Sequence 2:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster

Alignment Length:	718	Identity:	200/718 - (27%)
Similarity:	291/718 - (40%)	Gaps:	199/718 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 HRAPAPRGPSAIPDPGLSGGGSRGAGCEKAPPGRAPAPGLTPLRPSEPTMAVPPGHGPFSGFPGP 76
            |..|..:..||     .:|.||.|:   ||..|    ||             |.|.||.|..  .
  Fly   110 HGPPVQQDSSA-----AAGAGSVGS---KAGSG----PG-------------PDGIGPISSL--K 147

Mouse    77 QEHTQVLPDVRLLPRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSST 141
            ..||:|                                          |.....|...||...|:
  Fly   148 TAHTKV------------------------------------------ATSGGHANTQPPSKRSS 170

Mouse   142 KKEKKVLNHGYDDD----NHDYIVR-SGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKI 201
            .        |.|.|    .|:.:.. |.|     ||:...:|:|:||||||.:...|.|:|||||
  Fly   171 S--------GADGDYQLVQHEVLYSLSAE-----YEVLEFLGRGTFGQVVKCWKRGTSEIVAIKI 222

Mouse   202 IKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHF 266
            :||..::..|.|||:.:|..::|.:.: ::..|.....|..:||.|||||:|..||||.|:...|
  Fly   223 LKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQNKF 286

Mouse   267 RGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQR 329
            ..:.|...|.:.:|:.||||.|  .:|.:||.|||||||:|.:|.|.  .:|::||||:..:.:.
  Fly   287 SPLPLKYIRPILEQVLTALLKL--KQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT 349

Mouse   330 IYQ-YIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPP 393
            :.. |:|||:||:||::||.|:..|||||||||::.|:..|.||:.||:|.||:..|.:..|:|.
  Fly   350 VCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPT 414

Mouse   394 APMLEQAPKARKYFER-----LPGGGWTLRRTKELRKDYQGPGTRRLQEV-------------LG 440
            ..||..|.|..|:|.|     .|  .|.|:.|:|    ::.....:.:|.             :.
  Fly   415 EHMLNSASKTSKFFYRDVDSTYP--FWRLKTTEE----HEAETNTKSKEARKYIFNCLDDIGQVN 473

Mouse   441 VQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRT--ADEATNTGP 503
            |.|...||:...|    ..|...|.||:.|||..:...|::|..||.|.|.|.|  .|..
  Fly   474 VPTDLEGGQLLAE----KTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYV----- 529

Mouse   504 AGSSASTSPAPLDTC---------PSSSTASSISSSGGSSGSSNDNRAYRYSNRYCGGPGPPITD 559
            ..::...|...::.|         |:|:..::...      ||.:|..:..:|:........:.|
  Fly   530 YCNNVKASVQMMEVCRRGDFHTVQPASTLVTNFVP------SSTENMTFTINNQLTSQVQRLVRD 588

Mouse   560 CEMNSPQVLPSQPL------RPWAGGDVPHK---------THQ------APISASTLP------- 596
                      .:||      :.:.|..|..:         .||      .|.|..|:|
  Fly   589 ----------GRPLAYEGLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPSPTKHVV 643

Mouse   597 -GTGAQLPPL---PRCLGRPPSPTSPPPPELMDVSLVGSPPDCS--------------PPPPAPA 643
             |:....|||   |:.....|.|.|...|......|:.:....|              |..|..|
  Fly   644 VGSATMQPPLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGVAWPQTGRQMALVPSWPQQA 708

Mouse   644 PQH 646
            |.|
  Fly   709 PAH 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk1b	NP_001258299.1	PKc_DYRK1	157..496	CDD:271128	135/362 (37%)
Dyrk1b	NP_001258299.1	S_TKc	171..491	CDD:214567	129/340 (38%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	129/340 (38%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840