Protein Alignment Dyrk1b and Dyrk2

DIOPT Version :9

• Sequence 1: NP_001258299.1
• Gene: Dyrk1b / 13549
• MGIID: 1330302
• Length: 689
• Species: Mus musculus
• Sequence 2: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 597
• Identity: 204/597 - (34%)
• Similarity: 290/597 - (48%)
• Gaps: 124/597 - (20%)

Mouse    10 GPHRAPAPRGPSAIPDPGLSGGGSRGAGCEKAPPGRAPAPGLTPLRPSEPTMAVPPGHGPFSGFP 74
            |..|..:.:..|:      ||.||.|........|.....  ||:.|||
  Fly   126 GNERGSSTKSNSS------SGSGSSGNSASSTGSGELKCN--TPMTPSE---------------- 166

Mouse    75 GPQEHTQVLPDVRLLPRRLPLAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDS 139
                              |...||:.    |..|..:.:|.||.:  .|:.:...:....|...:
  Fly   167 ------------------LVKKFRNY----LTDLEFEELKVYKEV--WYFGQHASKNYNKPAPTA 207

Mouse   140 STKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKN 204
            :|      .|.||||||.:|.:...:....||||..:|||||||||::|.||:|...||||||:|
  Fly   208 NT------TNLGYDDDNGNYKIIEHDHIAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIRN 266

Mouse   205 KKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV 269
            ||.|||||.:||.:|:.:.:.|.:..:.::|:..:..||.|||:.|||:|.|||:|::..::.|.
  Fly   267 KKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLNLYELIKKNNYNGF 331

Mouse   270 SLNLTRKLAQQL--CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQ 332
            |::|.|:....:  |..||:    :.:|||||||||||||.....|:||::||||||.:.::||.
  Fly   332 SMSLIRRFCNSIVKCLRLLY----KENIIHCDLKPENILLKQRGSSSIKVIDFGSSCYVDRKIYT 392

Mouse   333 YIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPML 397
            ||||||||||||:||..|..|||||||||||.|::||.|||.|.|||:|::.|:||||:||..::
  Fly   393 YIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLGLPPKVLI 457

Mouse   398 EQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYL 462
            ..|.:.|.:|:...... .:..||..::   .||::.|..:|                |....|
  Fly   458 SVARRRRLFFDSRDAPR-CITNTKGRKR---SPGSKSLAHIL----------------HCQDRY- 501

Mouse   463 RFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSI 527
             |.|.:.|.||::||.|::|..|..|.|.:          |:.||...|      |..||:
  Fly   502 -FIDFLQRCLEWDPAERMTPDEAAHHEFLQ----------PSASSRHRS------CRMSSS---- 545

Mouse   528 SSSGGSSGSSNDNRAYRYSNRYCGGPGPPITDCEMNSPQVLPSQPLRPWAGGDVPHKTHQAPISA 592
            |||.|.:..|..:..|.:|....|..||.:......:                   ..|.|.|:.
  Fly   546 SSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTT-------------------AVHNAAIAT 591

Mouse   593 STLPGTGAQLPP 604
            :|   ...|.||
  Fly   592 TT---KSRQQPP 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk1b	NP_001258299.1	PKc_DYRK1	157..496	CDD:271128	148/340 (44%)
		S_TKc	171..491	CDD:214567	145/321 (45%)
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	159/376 (42%)
		S_TKc	233..529	CDD:214567	145/321 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840